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44,293 grants found
Showing 441 – 460 of 44,293 grants
Investigating the pathogenetic mechanisms leading to glaucoma surgery failure & development of new targeted therapeutics
Glaucoma is a major health problem and blinds millions of people worldwide. Glaucoma surgery is used to prevent blindness but traditional glaucoma surgery (trabeculectomy) fails pr...
Artificial Intelligence for Autonomic Urban Traffic Control
More than half of the world's population now resides in cities, and global urbanisation continues at a steady pace. This trend exacerbates mobility issues, with the average UK citi...
Unlocking potential: developing innovative adolescent screening visits for health promotion, prevention and treatment in low-resource settings
In adolescence, health-related behaviours are adopted that will have substantial positive or negative impacts on the individual's short- and long-term health, educational attainmen...
Combination chemotherapy versus Bacillus Calmette-Guérin (BCG) for high-risk non-muscle invasive bladder cancer– a phase III multi-centre randomised controlled trial (COBRA)
Research question Are adjuvant intravesical gemcitabine and docetaxel (Gem-Doce) bladder instillations non-inferior to Bacillus Calmette-Guérin (BCG) in terms of high grade recurr...
Co-production and piloting of socio-culturally embedded systems strengthening interventions to improve quality of care for people with mental health conditions in Somaliland (CopilotS).
Background Mental health conditions (MHCs) are highly prevalent in Somaliland, while services to treat them are frequently of low quality and rarely provide respectful, rights-ba...
Promoting Accessibility in Clinical Trials (PRACTICALs): Development and pilot testing of an eLearning resource
RESEARCH AIM: The design and pilot evaluation of a handbook and online learning modules for researchers and ethics committees on improving the accessibility of clinical trials fo...
Emotional and Language recovery in Aphasia (ELA): a feasibility study developing a novel intervention for people living with post-stroke aphasia
Background and objectives People with post-stroke aphasia, a language disability, are at risk of becoming depressed, anxious and isolated. They want therapy to focus on communicat...
Rehabilitation for individuals with chronic limb threatening ischaemia post-revascularisation (HOPE): a co-created feasibility trial.
Research question: Is a purpose-built rehabilitation intervention co-developed with patients and experts feasible to be used in people with Chronic limb threatening ischemia (CLTI)...
Designing and pilot testing an anticholinergic medication index clinical decision support system (ACMICS) for use in hospitals to support safer prescribing for older people at risk of medication-related harm.
Background Anticholinergic medicines are prescribed for various conditions such as urinary incontinence and intestinal spam and can pose harmful unintended side-effects. The cumula...
Equitable Palliative care In the Community through Primary Care (EPIC-PC): a realist study to propose a new integrated neighbourhood team approach to palliative and end of life care.
Research question: What are the key contexts, resources and components required for an integrated approach to palliative and end of life care to deliver improved and more equitab...
Developing an NIHR Health and Social care Delivery Research (HSDR) national evaluation team. The InterDisciplinary Evaluation of complex innovations in heAlth and Social care (IDEAS) Team.
Our Team. The InterDisciplinary Evaluation of complex innovations in heAlth and Social care (IDEAS) Team will evaluate complex innovations in health and care services, organisation...
PREDICT: Pragmatic Recalibration and Evaluation of Drift In Clinical Tools
Research question Can existing techniques be used to detect and repair temporal drift in clinical prediction models, to minimise risk of patient harm? Background There is a p...
Determining how Health Visitors can be agents of change alongside parents in reducing the prevalence/mitigating the risk of alcohol related developmental disorders in England: exploratory mixed methods study
Research question: How can Health Visitors (HV) be agents of change alongside parents in reducing the prevalence/mitigating the risk of alcohol related developmental disorders i...
EASE-CF: Evaluating and addressing excess weight in adults with cystic fibrosis: a registry analysis and a feasibility randomised controlled trial with an embedded qualitative study.
In 2020, 90% of adults with cystic fibrosis (CF) in UK started CF transmembrane conductance regulator modulator treatments. With these treatments, people have more stable disease a...
NIHR Short Placement Award for Research Collaborations 2023
Training Award
Doctors on the Streets: Health, Citizenship and Political Mobilisation of Medical Professionals in Pakistan
My career vision is to lead the field of anthropological research on health policy and systems in Pakistan, in order to drive new directions in this field, and promote scholarly ca...
Capturing fusion glycoproteins in motion: a focus on Ebola virus
The Ebola virus (EBOV) fusion glycoprotein GP mediates cell entry and is the main virus antigenic target. The molecular mechanisms underlying entry and antibody-mediated neutraliza...
Between deception and dissent: regulating unproven, disproven, or misleading health-related claims
This Discovery Award will explore how unproven, disproven, or misleading health-related claims are regulated in contemporary states; examine the socio- political implications of cu...
Predicting long-term outcomes in people with psoriasis who achieve disease control on systemic therapy: a mixed methods study
Background Psoriasis is a common, incurable inflammatory skin disease associated with high psychosocial morbidity and economic impact. Systemic therapy is often required for indivi...
Supracellular coordination in tissue morphogenesis
How organ shape is genetically encoded remains a major unresolved question in biology. All tissues arise from simple primordia that become patterned through transcriptional changes...