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Meaning in Science, Evaluative Scientific Concepts, and the Fact-Value Separability of Mixed Social Science
I am proposing to examine, in detail, Hilary Putnam's claim that the 'irreducibly evaluative' content of our evaluative concepts makes empirical social scientific inquiries into t...
A human intervention study using Human Milk Oligosaccharides to improve Irritable Bowel Syndromesymptoms through targeting of the gut microbiota
Irritable Bowel Syndrome (IBS) is the most common gastrointestinal disorder in the UK and a major public health/economic concern. It is associated with a range of mental and physic...
Using electronic health records to help support the diagnosis of hard-to-suspect conditions in primary care associated with diagnostic delay
My project will support efforts to improve the quality and safety of medical diagnosis. I will focus on exemplar conditions known for their diagnostic difficulty - resulting in lon...
The role of ER-phagy in pancreatic tumour initiation
Autophagy or ‘self-eating’ is a process by which cells remove unnecessary or dysfunctional cellular components by transporting them to the lysosome (the waste disposal system of th...
Investigating TDP-43 related splicing changes and therapeutics in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive paralysing illness resulting from the degeneration of upper and lower motor neurons. The pathological hallmark, present...
Using Knowledge Graphs to repurpose drugs for Motor Neurone Disease and Frontotemporal Dementia
There are no effective drugs to significantly modify the course of two serious medical conditions: motor neurone disease (MND) and frontotemporal dementia (FTD). These conditions a...
Arginine metabolism and T cell function in severe infection
I wish to understand why different patients with the same initial insult can have wildly different outcomes in Intensive Care. Poorer outcomes are associated with higher rates of h...
Effort-based decision-making, reward, and dopamine in depression in Parkinson’s disease
Parkinson's disease is the fastest-growing neurodegenerative condition globally. Depression is common in Parkinson’s affecting up to a third of patients. However, our understanding...
How do HIFs selectively activate a transcriptional response?
All organisms have evolved to sense and respond to oxygen availability in their environments, and at a cellular level oxygen sensing is mainly controlled by Hypoxia Inducible Facto...
Leveraging rare genetic variation to understand the role of Liver X Receptor in human glucose and lipid metabolism
Genes are the instruction manual of our cells. They contain the code (in the form of DNA) that enables our cells to make all that is necessary to function. Small changes in our gen...
understand how the lung environment affects colistin treatment efficacy and to develop new therapeutic strategies to improve patient outcomes
Cystic fibrosis (CF) affects >10,000 people in the UK. Early mortality characterises the disease, largely driven by chronic lung infection and inflammatory airway wall damage....
IoT sensing, data analytics and mechatronics for aerospace manufacturing
IoT sensing, data analytics and mechatronics for aerospace manufacturing
The calibration of decision-analytic models.
Background: Mathematical models are often used to inform decisions on how best to spend finite public health resources. These models combine relevant information (in the form of mo...