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44,293 grants found
Showing 44,221 – 44,240 of 44,293 grants
Identifying tumour-immune interactions as determinants of clinical sequelae in chronic lymphocytic leukaemia
Background: The immune system possesses anti-tumour capabilities that can be harnessed to eradicate cancer. However, it is currently unknown what aspects of anti-tumour immunity de...
Development and clinical validation of a multi-modal liquid biopsy test for cancer screening and monitoring using long-read sequencing technologies
Background. Detecting cancer early is fundamental to improve survival rates, as prognosis for advanced and metastatic cancers is dismal. Liquid biopsy (LB) methods based on detecti...
Improving our understanding of e-cigarette and refill packaging in the UK (E-PACKS): How is it used for product promotion, how is it perceived by consumers, and could it be changed to discourage youth while encouraging adult smokers to quit?
Background: There is limited research on e-cigarette packaging and labelling, particularly in comparison to cigarettes. Few studies have explored how e-cigarette packaging is being...
Cancer Research UK Clinical Trials Unit at Leeds Fellowship- developing a future chief investigator of advanced radiotherapy clinical trials
Background: Radiotherapy is a key component of the curative management of approximately 50% of patients with cancer. Better understanding the role of radiotherapy in precision medi...
CRUK/12/036: SIOP Intracranial Ependymoma II; An International clinical trial for the diagnosis and treatment of children, adolescent and young adults with intracranial ependymoma
Background The clinical management of ependymoma in childhood to young adults is complex and the clinico-bio-pathological correlates of outcome remain poorly understood. Overall th...
CRUK/21/010: LOGGIC Core - Bioclinical Data Bank
Background LOGGIC Core and LOGGIC Europe are two studies in the UK, which are part of larger European studies addressing questions in children and young adults (up to 21) with paed...
Personalised, data-driven surgical management of pituitary tumours using artificial intelligence – a pilot study
Background: The gold standard treatment for most patients with symptomatic pituitary tumours is surgical excision via the endoscopic transsphenoidal approach (eTSA). These operatio...
Optimising Immuno-oncology Approaches in Oncology
Background: The MRC Clinical Trials Unit is the largest of its kind in Europe, running practice changing trials in cancer, infections and neurodegenerative disease. A key programme...
Decision-making instabilities.
Many social and technological systems can be viewed as networks of interacting decision makers. In economics, for example, these might be networks of companies, investors, and regu...
Targeting miR-21 to inhibit the inflammatory response following ischaemic kidney injury
Around 5000 people in the UK are waiting for a kidney transplant as the optimum treatment in kidney failure. To meet this demand there is a push to use organs from more marginal do...
Optical spectroscopy to enable screening in the liver transplant theatre
The project is based around the concept of using Raman Spectroscopy as a method to assess the quality of organs prior to transplantation. The sensing is the measurement of metaboli...
Diamond magnetometry for finding corrosion in steel
Diamond is radiation hard, and the sensor head of our diamond magnetometer could be too which would enable it to be used in radioactive environments. Working with the National Nucl...
Development of remote optoelectronic sensor systems for long term component monitoring.
Advanced optical sensing and instrumentation offers the means to monitor complex environments that may not be possible using conventional sensing techniques. This project aims to d...
Laser sources and semiconductor optical amplifiers for free-space orbital angular momentum communication systems
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because...
New Optical Imaging and Analysis Techniques for the Early Detection and Quantification of Corrosion on Special Nuclear Materials Packages
This PhD research will focus on designing novel signal and image processing techniques using a combination of state-of-the art Deep Neural Networks and Traditional methods to segme...
Great Mental Health in Haringey Community Protect (PHIRST Insight)
Poor mental health affects large numbers of people every year and has far reaching consequences, including poorer life expectancy and quality of life, higher risk of poor physical...
PHIRST Fusion Evaluation of the North Yorkshire County Council Living Well Smokefree Service: a Hybrid Specialist Stop Smoking Service offering a blend of face-to-face and remote service provision (PHIRST Fusion)
PHIRST Fusion evaluation of ‘Living Well Smokefree’ a Post COVID-19 Hybrid Specialist Stop Smoking Service involving a blend of face-to face and remote service access. Backgroun...
Interventions to increase COVID-19 vaccination uptake and reduce vaccine hesitancy (PHIRST Fusion)
Background: Vaccines are a central component of the UK Government’s strategy to bring about the end of the COVID-19 pandemic. However, mass immunisation requires a significant maj...
An evaluation of Southwark Council’s summer 2022 Holiday Activities and Food programme (PHIRST Fusion)
Background In 2018, the Department for Education (DfE) first piloted the Holiday Activities and Food programme (HAF). It was a scheme that provided funding to a select number of...
Lambeth Prevention and Promotion for Better Mental Health and Wellbeing (PHIRST Connect)
The Prevention and Promotion for Better Mental Health and Wellbeing programme was launched in Lambeth in September 2021 to provide support to vulnerable residents and groups as a r...