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44,293 grants found
Showing 43,781 – 43,800 of 44,293 grants
BRCA-DIRECT: piloting a digital platform enabling clinically-integrated, clinician-independent, rapid, genetic susceptibility biomarker testing
Background Germline BRCA biomarker status is an incontrovertibly powerful biomarker of cancer risk enabling identification of individuals at very high risk of cancer in whom measur...
CRUKD/21/005 CURATE A CRUK first in human Phase I/II trial of TT702, a selective adenosine A2BR agonist, given orally as a monotherapy & in combination in advanced cancer including prostate cancer (mCRPC)
Adenosine is a purine nucleoside which confers potent immunosuppressive as well as direct tumour-promoting effects in the tumour microenvironment (TME). Approaches to block adenosi...
Exosome-based diagnostic module for early cancer detection
Background Exosomes are membrane-bound spherical structures (10-150 nm) secreted into the interstitial fluid by all cell types ubiquitously. They carry signatures specific to the p...
Identification of tumour-specific spliced epitopes to target large cohorts of cancer patients by immunotherapy
Identification of tumour-specific spliced epitopes to target large cohorts of cancer patients by immunotherapies Background Targeting CD8+ T cells to recurrent tumour-specific muta...
Understanding ethnic variations in the prevalence and experience of food insecurity, and its interaction with mental health: A mixed-methods longitudinal research programme
This Fellowship will explore the intersection of contemporary marginality, ethnicity and mental health through an integrative mixed methods study of the prevalence, causes, and liv...
Biomedical Vacation Scholarship Programme - University of Nottingham
This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cove...
Patient behaviour: Investigating new determinants and exploring effects on maternal and neonatal health in Kenya
Patient behaviour plays a key role in determining whether health systems are able to maintain and promote health. One area where it is crucial to study patient behaviour is materna...
Understanding and inducing immunity against rabies and Epstein Barr virus Class III fusion proteins
Viral fusion proteins are important targets for vaccine-induced neutralising antibody. Structure-guided design of such antigens in pre-fusion conformation has created leading vacci...
Informing strategies for malaria eradication: a combined epidemiological and economics approach
The last decade has witnessed substantial declines in the global burden of malaria; however, in recent years progress has stalled. We aim to combine a mathematical modelling framew...
Next generation atomic force microscopy for solving problems in biomedicine
AFM has unique capabilities for understanding life, and is able to image living systems in their native state under physiological conditions with molecular resolution. However, tec...
Schistosome and Snail Resource (SSR); supporting global schistosomiasis research
Schistosomes, transmitted by freshwater snails, infect >200 million people in low/middle-income countries, particularly sub-Saharan Africa. While substantial advances have been mad...
Harnessing endogenous mechanisms to promote cardiac regeneration
The funding will enable the development of a first in class therapeutic for the repair of heart muscle based on modifying an endogenous molecule fully-reduced High Mobility Group B...
Dopaminergic reorganisation of cross-region neural communication
Dopamine (DA) neurons in the ventral tegmental area (VTA) are thought to provide a reinforcement signal that is essential for learning. Despite recent advances, how VTA-DA neurons...
Investigating the role of gut macrophages in mediating alpha-synuclein pathology in Parkinson’s disease
The gut-brain axis is at the heart of Parkinson’s disease (PD) etiology. Pathological alpha-synuclein accumulates early in the gut, potentially affecting the enteric nervous system...
Elucidating the structure and function of the divergent and essential cytochrome bc1 complex in apicomplexan parasites
Apicomplexan parasites, which include Toxoplasma and Plasmodium, cause deadly human diseases, such as toxoplasmosis and malaria. Understanding their divergent cell biology could in...
“Investigating regulatory landscapes in oesophageal adenocarcinoma”
Oesophageal cancer is the 14th most prevalent cancer and the 7th most common cause of cancer death in the UK. Oesophageal Adenocarcinoma (OAC) is the most common subtype within Wes...
Streptococcus pyogenes carriage acquisition, persistence and transmission dynamics within households in The Gambia: a longitudinal cohort study
Group A Streptococcus (GAS) is a bacteria which causes severe infections and leads to deadly diseases such as rheumatic heart disease which kills over 300,000 people a year globall...
Quantitative investigation of the control of mRNA degradation in Drosophila early embryogenesis and the impact of stability on developmental processes
Gene expression allows organisms to convert the genetic code in their DNA into proteins which carry out specialised functions in cells. In early embryonic development, cells tailor...
Structural and Biophysical Characterisation of ESCRT-0
In order to sense and respond to outside events, eukaryotic cells utilise many different proteins on their surface to finely control activities such as growth and movement. Key to...
Exploiting SUMOylation to target MYC-driven cancers
MYC is a protein which is known to contribute to the development of cancer. It is found in many different types of cancer cells at much higher levels than it would be in healthy ce...