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44,293 grants found
Showing 43,761 – 43,780 of 44,293 grants
Provision of multi-parameter fluorescence-activated cell sorting for functional and genomic analysis of immune cells
This application is for the purchase of a BD Aria-Fusion fluorescence activated cell sorter.The instrument performs high-speed multi-parameter sorting, allowing isolation of rare c...
Renewal of WT funding for Centre for Macaques
Renewal of funding for Centre for Macaques (CfM) to August 2022
Defining the Protective Immune Response to SARS-CoV-2 Using a Human Challenge Model
Understanding the nature, effectiveness and durability of the human immune response to SARS CoV2 is crucial for vaccine development and effective public health management.We are be...
Molecular and cellular mechanisms directing neuronal microtubule rearrangements during vertebrate CNS development
Polarity, the asymmetric organisation of cellular components, is crucial for the function of many cell types.Newborn neurons in the developing spinal cord shed their tips to move t...
Academy of Medical Sciences: Breaking Boundaries
The Academy of Medical Sciences’ mission is to advance biomedical and health research and its translation into benefits for society.The vision set out in this proposal is central t...
TyVOID
The overall objective of this proposal is to provide new evidence to support the elimination of typhoid from regions of the world where there is a substantial burden that threatens...
Inclusive Design for Dementia (ID4D) Dunhill Medical Trust PhD Studentships
An ageing population is placing greater demands on care services/providers and presenting new challenges to people wishing to remain in their homes safely and independently for as...
A collaborative platform and network for responsive infectious diseases bioethics research
We seek to establish a research network and collaborative platform for rapidly identifying and analysing ethical and policy issues arising in infectious disease treatment, research...
Death and dying in the UK today: improving outcomes and experiences through evidence-informed policy engagement
Death and dying in the UK today: improving outcomes and experiences through evidence-informed policy engagement
The burden of cardiovascular disease in patients with kidney disease: temporal trends & treatment gaps (Dr Peter Gallacher)
Cardiovascular disease (CVD) is inextricably linked with kidney disease and is its commonest complication. Historic data indicate that CVD risk increases as renal function declines...
University of British Columbia Advanced Cardiac Imaging Fellowship: 1) Understanding bioprosthetic leaflet degeneration in patients with and without type 2 diabetes - a pilot study, and 2) Coronary artery plaque characteristics and their association with outcomes - analyses from the ISCHEMIA trial
During the UBC Advanced Cardiac Imaging Fellowship, two research studies will be undertaken (complete abstracts included in the case for support): 1. Understanding Bioprosthetic Le...
Developing human iPSC-derived engineered atrial tissue for mechanistic study of atrial fibrillation and novel therapy development (Mr Alexander Grassam-Rowe)
Atrial fibrillation (AF) is the most frequently encountered cardiac arrhythmia in clinical practice and represents a significant disease burden worldwide.The development of novel t...
Neuropeptide-Y pathophysiology in the development of heart failure
Acute myocardial infarction (AMI) and chronic systolic heart failure (CHF) result in high levels of cardiac sympathetic stimulation, which is a poor prognostic indicator.Whilst bet...
Investigating the causes of mutation-negative hypertrophic cardiomyopathy: Role of cryptic RNA mis-splicing in myosin binding protein C (MYBPC3)
Hypertrophic cardiomyopathy (HCM) is defined as left ventricular hypertrophy in the absence of abnormal loading conditions. It is the commonest genetic heart disease and a major ca...
Functional investigation of the coronary artery disease associated gene SVEP1 in vascular smooth muscle contraction
Large-scale genetic association studies have been successful in identifying the genetic contribution to coronary artery disease (CAD).However, for the majority of loci the mechanis...
AMS Professorship award for Professor Juanma Vaquerizas, Imperial College London
In the work I propose here, I aim to capitalise on our previously gained expertise in examining chromatin conformation during early development and regulation mediated by repetitiv...
AMS Professorship award for Professor Wenying Shou, University College London
I plan to move my lab from the Fred Hutchinson Cancer Center (FHCC, USA) to University College London (UCL) in January 2021. An AMS professorship will be critical to start my new l...
Developing a patient-centred evidence-based intervention to address distress in the context of chronic MSK pain
People with chronic musculoskeletal pain are often diagnosed with co-morbid depression, and commonly prescribed antidepressants.However, there is strong evidence to suggest that di...
Does peripheral neuroinflammation predict chronicity following whiplash?
The incidence and socioeconomic consequences of whiplash appear undiminished.Most whiplash cases are considered grade 2 whiplash associated disorder (WAD2), which refers to patient...
Towards High-Throughput Detection of Ovarian Cancer Cells from Liquid Biopsy using Stimulated Raman Scattering
While the previous two decades have seen a dramatic improvement in general cancer survival rates, for some pervasive cancer types such as Ovarian Cancer (OC), survival rates have o...