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44,293 grants found
Showing 43,741 – 43,760 of 44,293 grants
Scaling an affordable wireless vital signs monitor for patients in low- resource settings
Through user-centric design, Neopenda aims to create needs-based solutions that benefit underserved populations, enable high quality patient care, and provide nuanced data insights...
TYPIST ARTIST PIRATE KING
Typist Artist Pirate King is an innovative and accessible dramatic feature film drawn from the extensive archives of art, diaries and letters held at Wellcome of artist and mental...
The Economy 2030 Inquiry: navigating a decade of change
This ambitious project is the first funded through the Nuffield Foundation’s Strategic Fund.It will explore three major changes facing the UK economy – Brexit, and COVID-19 and the...
Who can 'have it all'?: job quality and parenthood in the UK
This project will examine the relationship between job quality and parenthood in the UK.The ‘motherhood penalty’ and ‘fatherhood bonus’ in income are well-researched, but little is...
Antimicrobial bio-resin composites for rail and aircraft interiors (COATECT)
The COATECT project will explore the feasibility of combining antimicrobial coatings with bio resin-based prepregs, to deliver a new class of sustainable composite materials for us...
Detection of High-Risk Plaque with tropoelastin-specific and multicontrast coronary MRI (renewal)
Dysfunctional extracellular matrix (ECM) remodelling, intraplaque haemorrhage (IPH), and thrombus are promising imaging biomarkers for the identification of high-risk patients in a...
Selecting Rhythm or Rate Control in Patients with both Atrial Fibrillation and Heart Failure
Heart failure (HF) and atrial fibrillation (AF) are common co-morbidities (AF-HF).AF-HF patients have two treatment options: rate control, where AF is not treated but drugs are use...
Investigating the topography of adaptive immunity in the cardiovascular system: Basic mechanisms and therapeutic potential (renewal).
A growing body of evidence suggests that inflammatory processes within the heart are an important cause of cardiac disorders and determinants of disease progression and outcome. Th...
RNA helicases as regulators of the response of B-cells to programmed DNA rearrangements
In mature B-cells, the generation of antibodies of different isotypes relies on class switch recombination (CSR) mechanisms.Although crucial for adaptive immunity, CSR imposes chal...
Mapping the energetic pathways of the brain: Ultra-high-field MRI of cerebral oxygen and glucose utilisation
Aerobic glycolysis (AG) plays a vital role in brain disease, development, and ageing.Elevated AG has been linked to axonal elongation and synaptogenesis in childhood, synaptic plas...
Exploiting divergent biology of two fission yeasts to understand membrane function
Membrane function is fundamental to life. Deregulation of the membrane lipid repertoire has severe consequences for cellular and organismal fitness.Defining how lipid composition c...
Genetic Code Compression and Expansion
Genetic code expansion enables the site-specific, incorporation of non-canonical amino acids (ncAAs) into proteins, and has enabled diverse biological discoveries. Most experiments...
Exploiting genomic approaches to identify the environmental basis of depression
Despite major advances in our understanding of depression’s genetic architecture, there remain major gaps in our understanding of its environmental risk factors that impede prevent...
Controlling emergent Anopheles stephensi in Ethiopia and Sudan (CEASE)
Malaria is predominantly a rural disease in Africa and whilst urbanisation is occurring rapidly it was thought unlikely to lead to substantial increases in malaria transmission bec...
A multi-centre, prospective, double-blinded, pilot study evaluating artificial intelligence driven automatic detection of proximal deep vein thrombosis (DVT).
Our long term vision is to revolutionize the cumbersome diagnostic pathway for DVT.We aim to use ground-breaking artificial intelligence (AI) software to eliminate the need for hig...
Proof-of-Concept for α5-GABAAR PAMs in the treatment of psychosis
This project aims to validate the hypothesis that a small molecule that is a positive allosteric modulator (PAM) of α5-subunit-containing GABAARs (α5-GABAARs) can attenuate striata...
Mechanism of cell-to-cell transmission of flaviviruses
This proposal will investigate the mechanism of cell-to-cell transmission and spread of flaviviruses using Dengue and Zika as model systems.We will therefore address a longstanding...
Defining the impact of androgens on macrophage function during endometrial tissue repair
Macrophages are essential mediators of tissue repair but we lack fundamental knowledge about how they are regulated in the endometrium.Androgens regulate macrophage function in oth...
Socio-cultural and organisational variables as determinants of action in the implementation of infection prevention and control: a European in-depth comparative mixed method study
Europe
Academic DNA-Encoded Library Resource
Our goal is to enhance and accelerate the validation and translation of new drug targets identified by the UK academic biomedical research community.In order to achieve this we wil...