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44,293 grants found
Showing 43,621 – 43,640 of 44,293 grants
Airway microbiome driven mechanisms of disease after optimised self management: Colour-COPD trial
Research question: Do alterations in the airway microbiome and downstream inflammation occur if patients optimise self-management of exacerbations of chronic obstructive pulmonary...
Both EARS training package (BEARS) to maximise hearing abilities in older children and teenage bilateral cochlear implant users
Background Older children and teenagers with bilateral cochlear implants do not fulfil their potential due to poor sound localisation abilities and degraded speech-in-noise percept...
Integrating genetic testing into the prostate cancer pathway to more precisely guide care, treatment and accelerate clinical trials
Research question: How can the integration of genetic testing within the prostate cancer (PrCa) screening, diagnostic and management pathway improve patient care and be cost effici...
Estimating the value of future research to improve guidelines on thromboprophylaxis for women during pregnancy and after delivery
RESEARCH QUESTIONWhat is the value of undertaking a study to determine the clinical and cost-effectiveness of risk stratification tools for the prediction of venous thromboembolism...
Improving the Experiences of Black African Caribbean Men Detained Under the Mental Health Act: A Co-Produced Intervention Using the Silences Framework (ImprovE-ACT)
Aim: To inform, develop and explore the feasibility of a co-produced intervention to improve the experiences of Black African-Caribbean (BAC) men detained under the Mental Health A...
Ablative and non-invasive therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis
Design: Systematic review and network meta-analysisAim: The aim of this project is to review and compare the effectiveness of all current ablative and non-invasive therapies for pa...
PREPARE: imPRoving End of life care Practice in stroke cARE
Research questions How can we use stroke-specific indicators of dying to define eligibility criteria for a clinical trial? How do stroke care staff set end-of-life-care and support...
Rapid evaluation of the care home response to the need for palliative and end-of-life care during the COVID-19 pandemic: integration, communication and workforce resilience (CovPall_CareHome)
Background: COVID-19 has had a devastating impact on care homes, their residents and families, and staff. Over 20,000 care home residents in England have died from COVID-19 to date...
PROphylactic TrEatment of COVID in Care Homes Trial (PROTECT-CH)
The COVID-19 pandemic has had a devastating impact on care homes, causing illness and death and leading to restrictions on daily routines, including restricted visiting, that have...
Centralisation of specialist health care services: a mixed-methods programme
There have been significant changes in the provision of specialist clinical care in the NHS in recent years, with plans to centralise specialist services into fewer centres. Specia...
An Evaluation of COVID19 Public Spaces Management in South Gloucestershire (PHIRST Fusion)
AimAmidst the COVID-19 pandemic, South Gloucestershire Council introduced temporary travel schemes to increase active travel and facilitate social distancing. Working closely with...
Overarching study of service innovations for people with multiple long-term conditions: what works for whom, how and why?
BackgroundThe Birmingham, RAND and Cambridge (BRACE) rapid evaluation centre is funded by the National Institute for Health Research (NIHR) to conduct rapid evaluations of promisin...
Developing a falls management tool for older adults with intellectual disabilities in community settings
Background Falls rates for older adults with intellectual disabilities is higher than compared to the general older adult population [Finlayson et al, 2010].Although falls manageme...
A randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for depressed non-responders to Increasing Access to Psychological Therapies (IAPT) high-intensity therapies
Research question The proposed research will investigate whether Mindfulness-Based Cognitive Therapy (MBCT), a group-based treatment combining intensive training in mindfulness med...
What is the best second line therapy for people aged 65 years or over with type 2 diabetes?: systematic review and network meta-analysis
Research question What is the most effective and safe second line therapy for people aged 65-years and over with type 2 diabetes(T2DM)?Background One-in-six people aged 65-years or...
Adverse medical incidents and outcomes in the NHS: understanding prevalence, patients’ perspectives and factors that influence subsequent actions
Background Patients and families taking formal action when things go wrong remain relatively rare.The costs of litigation are high, both in terms of psychological consequences for...
SuperResPath-Renal: Quantitative super-resolution technology for a fast, de-centralised clinical diagnosis of renal pathologies
Background Renal pathologies are the most common primary cause of nephrotic syndrome.For diagnosis, a renal biopsy is examined at different levels, including high-resolution electr...
ChromaDose: In-vitro diagnostic device development and validation, enabling point-of-care therapeutic drug monitoring for dose optimisation of anthracycline chemotherapy in paediatric cancer settings.
Determining anthracycline dosage in childhood cancer is a clinical dilemma due to significant drug exposure variability between children.Despite their propensity to inflict dose-re...
The other keyworkers in care homes: implications of including domestic staff in social care workforce strategies and practices relating to Covid-19 recovery
Ancillary or domestic workers in care homes are key to infection control, routine cleaning and housekeeping tasks; they engage with residents; and assist care workers providing per...
Social Care Recovery and Resilience: Learning lessons from international responses to the COVID-19 pandemic in long-term care systems
Research question What can we learn from international evidence and experiences in order to support the recovery of the social care sector and to inform the development of policies...