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44,293 grants found
Showing 43,581 – 43,600 of 44,293 grants
Characterising the dynamic inter-relationships between polypharmacy and multiple long-term conditions. Using artificial intelligence (AI) to map patient journeys into multimorbidity clusters across the UK
Overarching question: “How do polypharmacy and multiple long-term conditions (multimorbidity)(MLTC-M) interact and can enhanced understanding of their inter-relationships...
Inflammatory drivers of long-term comorbidity trajectories: an AI investigation of mulitimorbidity (inflAIM)
About 25% of the UK population have two or more long term conditions.This multimorbidity is associated with a reduction in quality of life, increased use of health services and red...
CHAMPION - AlCohol HArM PreventIOn iN pregnancy
Research question: What are the components of an implementation intervention to support midwives provision of recommended care addressing alcohol consumption with women attending a...
19-BBSRC-NSF/BIO Characterizing efficiency and limitations of RNA regulators to achieve robust dynamic behaviours
Synthetic biology has made it possible to use cells to operate as microscale factories, energy sources, and even computers. However, the introduction of DNA circuits into cells can...
The south Asian Dementia diAgnosis PaThway (ADAPT) - an online tollkit of enhanced interventions
Of the 25,000 people from ethnic minority communities who are living with dementia in the UK, the largest, single grouping are people from South Asian communities.South Asians are...
Artificial intelligence for identifying new disease clusters in patients with immune-mediated inflammatory conditions: A Proof-of-Concept Study
The overall prevalence of immune-mediated inflammatory conditions (IMIDs) is estimated to affect 1 in 10 people in Europe and the United States.The most common IMIDs include rheuma...
Developing a Multidisciplinary Ecosystem to study Lifecourse Determinants of Complex Mid-life Multimorbidity using Artificial Intelligence (MELD)
Background Multimorbidity occurs earlier in the lifecourse among people from more disadvantaged backgrounds.Wider determinants such as housing, education and work influence develop...
Using deep learning approaches to examine serious mental illness and physical multimorbidity across the life-course: from mechanisms towards novel interventions
Research question: What are the clinically important clusters of serious mental illness-physical multimorbidity that influence patient outcomes, and the social, environmental, beha...
Factors Determining Clonal Selection in Germinal Centres
Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation (SHM) in dark zones (DZs) and selection in light zones (LZs).Current...
Healthy soil, Healthy food, Healthy people (H3)
Bringing together world-class researchers from Sheffield, Leeds, Bristol, Cambridge and City Universities, this proposal seeks to transform the UK food system 'from the ground...
Trust after Betrayal: Global development interventions in the shadow of organized violence
This project is an interdisciplinary investigation into global development interventions that unfold against the backdrop of organised violence. It applies a novel approach to stud...
Funding for epidemiological analysis to inform HMG’s COVID-19 response
Funding for epidemiological analysis to inform HMG’s COVID-19 response
AI-enabled point-of-care technology for radiotherapy planning peer review
Background Approximately 50% of cancer patients are offered radiotherapy treatment.An important part of radiotherapy planning involves delineating (“contouring”...
Real World Testing of PreSize Neurovascular: medical device software to optimise stenting surgeries to reduce complications
Research question: Develop evidence of efficacy and preliminary proof of effectiveness of PreSize Neurovascular software for planning brain stenting procedures. Background: Stents...
uSing rolE-substitutioN In care hOmes to improve oRal health (SENIOR)
Aim: To undertake a cluster-randomised controlled trial to determine whether Dental Care Professionals (DCPs) can reduce plaque levels (improve oral cleanliness) of dentate older a...
Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
Research questionIn infants hospitalised with bronchiolitis, does oral Broncho Vaxom (BV; a lysate of respiratory bacteria), given for 10 days per month for a total of 24 months, p...
Assessing the impact of introducing online postal self-sampling for sexually transmitted infections into sexual health provision within the UK on health inequalities, access to care and clinical outcomes. Short title: ASSIST
Research questions: 1.Does channelling to online postal self-sampling for sexually transmitted infections (STIs) and HIV: a. Impact on health inequalities b. Increase access to sex...
End of Life Care for Infants, Children and Young People: a mixed methods evaluation of current practice in the United Kingdom
Research question Do outcomes for infants, children and their families, and resources required, vary depending on the model of End of Life (EoL) care that they receive? Background4...
What are the barriers to young carers accessing carer support services and/or services for the recipient of care, and what interventions and support services are acceptable to these groups and the persons they look after?
Reducing Barriers and Improving Access to Support for Young Carers (REBIAS-YC) Research questionWhat are the barriers to young carers accessing carer support services and/or servic...
ESPriT2: A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women
RESEARCH QUESTION:What is the effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis (SPE) to manage endometriosis-associated pain? BACKGROUND:End...