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44,293 grants found
Showing 43,561 – 43,580 of 44,293 grants
Development of a computational glycan engineering tool for biologics manufacturers
Biologics are currently the most successful class of pharmaceuticals, with seven of the top 10 drugs marketed in 2018 hailing from this class and grossing a total of $60 bn. The ma...
AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment
Conventional evaluation of new medicines is too lengthy (typically 10-years) to meet the urgent need for treating and preventing COVID-19. Our challenge now is to accelerate this,...
Dynamic muscle function monitoring in older adults: development of a novel wearable device to measure muscle function
As people age, walking often becomes more difficult.This reduces mobility which increases the risk of falls and fractures, which may lead to loss of independent living, social isol...
Gravitational Waves
Gravitational Waves
Uncertainty Quantification for Expensive COVID-19 Simulation Models (UQ4Covid)
Accurate mathematical models of transmission are crucial for targeting successful interventions to combat the spread of SARS-Cov2. In the UK, established models are used to provide...
Understanding the negative sense intermediate in the replication of foot-and-mouth-disease virus
The UK 2001 outbreak of foot-and-mouth disease resulted in billions of pounds of losses to the agriculture and tourism industries.This disease is widespread in many parts of the wo...
UK Museums during the COVID-19 crisis: Assessing risk, closure, and resilience
Museums are a vital part of the UK's cultural and economic landscape. In England alone, they attract 100 million annual visits and have a turnover of £2.64 billion p...
Food and Networks in Early Medieval Societies: Wales and the West
This PhD project will explore human/animal relationships in early medieval Wales (approx. AD 700-1100) and their role and influence in husbandry practices, diet, trade and the econ...
Developing genetically encoded ultra-correlative tags for functional studies employing light and electron microscopy
A key biomedical goal is to understand how organelles and proteins cooperate to make organs work, in both 'normal' and diseased conditions, with the ultimate aim to impro...
Nature's Way: Co-Creating Methods for Innovating Nature-based Solutions for Public Health and Green Recovery in a Post-COVID World
This project aims to co-create Nature-based Solutions (NBS) knowledge to empower communities, organisations, and individuals to innovate NBS as alternatives for healthcare and soci...
Failure process and optimal design of hybrid adhesive joints - a microscale experimental and numerical approach
With development of new engineering materials, hybrid structures are now widely used to achieve desired performances by applying new materials instead of conventional ones. This is...
Sustainable Plastic Attitudes to benefit Communities and their Environments (SPACES)
Between 400,000 and 1 million people die each year in LMICs due to diseases related to mismanaged waste. Waste management is, however, a complex area, which affects multiple stakeh...
Epigenetics and hidden heritability in tomato
The information content of eukaryotic genomes is based primarily on the DNA sequence but there are additional layers that are dependent on methylation of cytosine residues in the D...
Counting birds and bees: promoting wellbeing of older people through engagement with nature-based conservation activities
Engaging with nature benefits the health and wellbeing of older people (Dahlkvist et al., 2016; Finlay et al., 2015). Nearby nature can increase physical activity (Ambrey, 2016).Pa...
SIRT1: A novel antithrombotic target in cardiovascular disease? (Miss María Rosario Blanco López)
Platelets play a pivotal role in atherothrombosis, with antiplatelet agents providing important reduction in clinical events.However, adverse bleeding and variable patient response...
Improving outcomes of out of hospital cardiac arrest (OHCA): applying behavioural science to enhance dispatcher assistance and increase rates of cardiopulmonary resuscitation
Out-of-hospital cardiac arrest is common and carries enormous mortality (higher in UK than other countries).Immediate cardio-pulmonary resuscitation (CPR) reduces mortality but is...
The BHF-Turing Cardiovascular Data Science Awards (Second Call): Molecular causal networks of hypertension – a machine learning approach (joint funding with The Alan Turing Institute)
Genome-wide association studies (GWAS) have found over a thousand genetic variants associated with blood pressure (BP). The biological underpinnings of their association with BP re...
DrosophiLAP: a live in vivo study of LC3-Associated Phagocytosis
My research proposal aims to better understand LC3-associated phagocytosis (LAP) by exploring it for the first time in real-time in a living organism: Drosophila.During the first f...
Sustaining locally-driven social care for those affected by dementia: A realist evaluation of successful Meeting Centres
Rationale: Social care for people living with dementia, who require support to live at home with a decent quality of life, is in crisis in many parts of the country, particularly i...
Statin Treatment Options during vaccination against inFLUenza (STOPFlu) : an observational study of the interaction between statins and influenza vaccination
Background Influenza vaccination is routinely advised for many at-risk groups including adults aged≥65-years and, and younger patients with diabetes and cardiovascular disea...