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44,293 grants found
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Room correction: a dynamic, adaptive approach
This part of the project investigates the use of adaptive filtering applied to sound while the listener is moving in the environment e.g a studio, a room at home. Adaptive filterin...
Appraising Social Distributions To Guide Levelling Up Health And Wellbeing During Covid-19 Recovery
Research Question How can the costs and outcomes of COVID-19 and the policy response be appraised in a way that shows differences between population groups. The answer is contingen...
Spatial heterogeneity in transmission and the impact of interventions: a mathematical modelling approach
This COVID-19 Rapid Response award is jointly funded (50:50) between the Medical Research Council and the National Institute for Health Research.The figure displayed is the total a...
Nintedanib for progressive fibrosing interstitial lung disease (PF-ILD) excluding idiopathic pulmonary fibrosis (IPF) [ID1599]
To appraise the clinical and cost effectiveness of nintedanib within its marketing authorisation for treating progressive fibrosing interstitial lung disease excluding idiopathic p...
Investigation into the role of omega-3 fatty acids and structural analogues on Kv7 channel function and vasodilator mechanisms (Ms Kamila Behnam)
Improved cardiovascular health is often attributed to the consumption of the omega-3 PUFAs docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).These essential fatty acids re...
Mechanisms of RUNX1 regulation in human developmental haematopoiesis and childhood leukaemia
All adult blood cells are derived from prenatal blood stem cells produced in the embryo, where the process is dependent on a gene named RUNX1. Blood cell formation and the developm...
Molecular mechanisms of DNA synthesis by the human replisome
Before mitosis, cells must make two accurate and complete copies of their genome, to ensure genetic stability across cellular generations.This challenging biochemical task requires...
CIBR 19-BBSRC-NSF/BIO: Next generation PDB - FACT infrastructure with value added FAIR data supporting diverse research and education user communities
The vision of this US RCSB Protein Data Bank/Protein Data Bank in Europe collaborative project is to improve data deposition, delivery, and management of three-dimensional (3D) mac...
Effective analysis and experimental design for CRISPR screens with scRNA-seq readout
Understanding how cell fate decisions are regulated is a key question in molecular biology.Building on the CRISPR revolution, exciting technologies (e.g., CROP-seq or direct captur...
Does neuromodulation have what it takes to silence tinnitus for the long-term?
It is estimated that 1 in 8 people in the UK suffer from chronic tinnitus.Currently, the most effective treatment strategies are psychological management approaches that reduce the...
Nivolumab with ipilimumab for untreated unresectable malignant pleural mesothelioma [ID1609]
To appraise the clinical and cost effectiveness of nivolumab with ipilimumab within its marketing authorisation for untreated unresectable malignant pleural mesothelioma.
Changing biodiversity in changing environments: Trait Changes across space and time
Global concern about human impact on biological diversity has triggered an intense research agenda on drivers and consequences of biodiversity change in the Anthropocene. Recent ev...
Hex-PORTMAN: Heat Flux Splitting in Porous Materials for Thermal Management
Thermal management plays a vital role in determining the efficiency, safety and reliability of technological development in a plethora of industries including aerospace, automotive...
Using the arts to mitigate the impact of Covid-19 among India's indigenous and nomadic communities
The proposed research aims to document, create awareness, and ease the short and long-term impact of Covid-19 among India's most precarious indigenous nomadic communities thro...
A capacity-building platform for advancing biostatistics in Ethiopia, Kenya and Malawi
The overarching goal of this proposal is to develop a self-sustaining capacity building platform for advancing biostatistical methodology research in Kenya, Malawi and Ethiopia.The...
COMIX Extension (Understanding the dynamics and drivers of the COVID-2019 epidemic using real-time outbreak analytics)
COMIX Extension (Understanding the dynamics and drivers of the COVID-2019 epidemic using real-time outbreak analytics)
Design and generation of novel modified cyclic peptide inhibitors for the oncogenic mortalin-p53 interaction
Background: There is a pressing need to develop new therapeutic agents to overcome toxicity of current chemotherapeutic agents as well as the emergence of drug resistant cancer cel...
Microfluidic preparation of niosomes nanoparticles for intracellular delivery of anti c-myc siRNA for treatment of breast and melanoma cancers
RNA interference (RNAi) is a post-transcriptional gene regulatory mechanism that involves the degradation of a target messenger RNA (mRNA) through the incorporation of short interf...
Molecular Epidemiology of Carbapenem-Resistant Enterobacteriaceae Isolated from NICUs of Gaza Strip Hospitals
The title of my proposed research is Molecular Epidemiology of Carbapenem-Resistant Enterobacteriaceae Isolated from NICUs of Gaza Strip Hospitals. Carbapenemase producing Gram-neg...
The CXCL2 chemokine promotes VEGF-A-regulated angiogenesis
Angiogenesis is the phenomenon of blood vessels sprouting from pre-existing ones.This can be caused by certain soluble or membrane-bound factors which activate the endothelium whic...