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44,293 grants found
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Role of Plexin D1 in flow-induced atherosclerosis progression
Atherosclerosis is a highly complex disease that is determined by a combination of local haemodynamic and systemic risk factors.Low and disturbed shear stress is a major determinan...
Quantification and modulation of vascular inflammatory activity for the detection and treatment of high-risk atherosclerotic plaque
Acute coronary syndrome (ACS), including myocardial infarction, is the leading cause of premature death in the UK accounting for 33,000 lost lives annually. ACS is primarily caused...
Novel mechanism of platelet activation in haemolytic diseases
Haemolytic diseases with genetic (e.g. sickle cell disease) or infectious (e.g. shigatoxin–producing Escherichia coli-induced haemolytic uremic syndrome) origins are characterised...
Defining the role of the CAD gene JCAD in vascular remodelling
JCAD is a novel gene, identified by GWAS as associated with coronary artery disease (CAD).In our current BHF project grant we found that Jcad alters atherosclerotic plaque formatio...
Incidence, consequences and natural history of left ventricular thrombus after acute anterior myocardial infarction (Dr Evangelos Tzolos)
In the aftermath of acute myocardial infarction, the combination of blood stasis and activated tissue factor frequently leads to the formation of left ventricular thrombus. This ca...
Incidental coronary calcification on thoracic computed tomography
The identification of coronary artery disease is critical to guide targeted preventative treatment to reduce the risk of subsequent myocardial infarction.Coronary artery calcificat...
Age-related arterial stiffening (ARAS): Biomarkers for disease stratification and identifying the molecular drivers of stiffening
Arterial stiffness predicts CV risk, and age is the key determinant of arterial stiffening.This proposal builds on our work identifying novel proteins that change with age and affe...
PKCα/TGF-β signalling axis: A novel therapeutic target for arterial medial calcification
Arterial medial calcification (AMC) is associated with increased cardiovascular mortality in chronic kidney disease (CKD) patients; no treatments exist.We reported previously that...
Intermittent hyperlipidaemia accelerates the development of atherosclerosis: cellular and molecular mechanisms
Background: Hyperlipidaemia constitute a major risk factor of atherosclerosis.Recent overlooked observations indicate that periodic variations in serum cholesterol levels are stron...
Elucidating the novel mechanism of Blood Brain Barrier permeability regulation by the cellular iron homeostasis
The purpose of Dr. Rand’s visit in Prof.Samira Lakhal-Littleton’s lab is to study iron homeostasis methodologies from a world-class specialists in the field and apply it to the Blo...
Evaluation of KIR-HLA genotypes in genetic risk for coronary artery disease in Palestinian population of Gaza strip
The visit will include two main components: The first component will include conducting a small research on one of the most common diseases throughout the world as a whole and amon...
Developing Brain Imaging Analysis Expertise for Predicting Treatment Response to Brain Stimulation in Geriatric Depression
Depressive disorders are among the leading causes of incapacity and disability worldwide.The burden of geriatric depression is expected to increase due to population ageing and its...
Defining mechanisms of hormone-dependent cancer disease progression
Background: Hormone-dependent cancers constitute two of the most common cancer types (ER+ breast and prostate cancer).Treatments that block the driving transcription factors, ER in...
How tumour-cell killing by T cells is initiated
Background Receptor signaling underpins the new treatments transforming cancer medicine.However, there is almost no agreement about how these receptors are triggered, even though a...
Targeting of aberrant epigenetic circuitries and associated DNA damage response in acute myeloid leukaemia
While advance in DNA sequencing technology has provided important insights into the genetic makeup of cancer cells, it is evident that cancers are also driven by epigenetic deregul...
Biomedical Vacation Scholarship Programme - University of Cambridge
This award is for 6 students per year for 5-years.It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover...
The role of short ACE2 in Sars-CoV-2 infection and patients susceptibility to COVID-19
The virus responsible for COVID-19, SARS-CoV-2 utilizes a protein on the surface of cells named Angiotensin Converting Enzyme II (ACE2) as an entry gate.The presence and amount of...
Digital equality in education
This project will conduct a pre- and post-pandemic analysis of digital inequality and academic attainment in Scotland.Digital inequalities are defined as differences in access to d...
The effect of curricula updates on technology diffusion
Technology Diffusion
Dynamics of bacterial warfare in the gut
ecology