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44,293 grants found
Showing 321 – 340 of 44,293 grants
NIHR Nottingham BRC
The National Institute for Health Research Nottingham (NIHR) Biomedical Research Centre (BRC) launched in 2017. The Nottingham BRC is a partnership primarily between the University...
Implementation of Metformin theraPy to Ease Decline of kidney function in Polycystic Kidney Disease (IMPEDE-PKD) Randomised Placebo-Controlled Trial
Research Question: Does metformin reduce the rate of kidney function decline in ADPKD patients with an eGFR = 45mls/min/1.73m2, who are at risk of disease progression Background...
Comprehensive geriatric assessment to sustain independence for older people living with heart failure with preserved ejection fraction and frailty
Aim To establish whether CGA (plus usual care) is a clinically and cost-effective intervention to sustain independence in instrumental activities of daily living (IADL) for older...
NERC Environmental Data Service 2023-2028
Environmental science, and in particular the data which underpins it, support a wide range of stakeholder requirements and use cases. For over 40 years, the implementation of NERC'...
NIHR Newcastle BRC in Ageing and Multiple Long-Term Conditions
Vision Our vision is to transform lives through world-leading research in ageing and multiple long-term conditions (MLTC). We will take 21st century approaches to driving discoveri...
TaILOR - trial of patient-initiated care leading to improved outcomes in rheumatology
Research Question: What is the clinical and cost-effectiveness of patient-initiated follow-up (PIFU) compared with standard booked appointments for people with inflammatory arthrit...
A randomised controlled trial to evaluate the clinical and cost effectiveness of the Action Falls rehabilitation programme compared to usual care alone to reduce falls in stroke survivors.
Question:?Does Action Falls (AF) reduce the number of falls in stroke survivors in the first year after discharge from hospital, when compared to usual care?? Background: Strok...
Full Title - The clinical and cost effectiveness of quetiapine for people with borderline personality disorder: A pragmatic, double-blind, placebo-controlled, randomised trial. Short Title - Quetiapine Effectiveness Study in Borderline Personality Disorder (QUEST).
Research question - What is the clinical effectiveness, cost-effectiveness, safety and tolerability of quetiapine for treating people with borderline personality disorder (BPD)?...
Tobacco RIsk reDuction with E-cigarette Nicotine Therapy among adults with serious mental illness (TRIDENT)
Research question Can people with serious mental illness (SMI) who smoke and who do not want to stop smoking be engaged to reduce harm from and eventually stop smoking with a bri...
Timing Of venous thromboembolism Prophylaxis for adult patients with Traumatic Brain Injury (TOP-TBl): a pragmatic, randomised trial
Research Question In adult patients admitted to a neuroscience hospital with a traumatic brain injury, does early pharmacological thromboprophylaxis administration (<72 hours from...
A 'safe Systems' Approach For Enabling Traffic Injury Prevention in Nepal (SAFE TrIP Nepal)
Research question How can we understand and address policy and practice barriers to inter-sectoral collaboration for the prevention and care of road injured patients in Nepal?...
Impact and inequalities of winter pressures in primary care: providing the evidence base for mitigation strategies
Background In England, primary care provision is unequally distributed by socioeconomic status and ethnicity, as is prevalence of chronic disease, uptake of vaccination, and imp...
T4P (Threshold for Platelets)
Research question In critically ill patients, below what platelet count should platelets be transfused for a planned procedure that might cause bleeding? Background Intensive...
Single and Safe Intervention for MEDication administration (SaSI-MEDs): The development and evaluation of an intervention to de-implement unnecessary double-checking of medicines in hospital
Medication errors are one of the most ubiquitous patient safety problems in modern healthcare, with 237 million errors occurring annually in England. Errors at the point of adminis...
DNA-based delivery of antiviral antibodies for Zika and Influenza prevention
RenBio proposes a two-pronged approach to evaluate the applicability of MYO Technology for DNA-based antiviral antibody delivery, using antibodies directed against Zika virus (ZIKV...
A primary care system-level training and support programme for the secondary prevention of domestic violence and abuse: a multicentre cluster randomised trial with economic and process evaluation
Background Domestic violence and abuse (DVA) is a major public health challenge. The IRIS (Identification & Referral to Improve Safety) primary care training and support programme...
Pre-Operative Radiotherapy and Deep Inferior Epigastric Perforator Flap Reconstruction - II Trial (PRADA-II Trial)
Research question Is preoperative radiotherapy superior to postoperative radiotherapy in improving patient-reported satisfaction with autologous breast reconstruction, 2 years fol...
Harnessing the diversity of African genomes to drive novel disease gene and pathway discovery for Amyotrophic Lateral Sclerosis (ALS) Spectrum Disorders
Large-scale next-generation sequencing has rapidly advanced our understanding of the genetic architecture of Amyotrophic Lateral Sclerosis (ALS) spectrum disorders which is driving...
Glucocorticoids in Adults With Acute Respiratory Distress Syndrome: Randomised Clinical Trial (GuARDS Trial)
Research question: What is the clinical and cost effectiveness of dexamethasone given early (within 72 hours of diagnosis) in acute respiratory distress syndrome (ARDS)? Design: M...
Evaluation of a sustainable obesity prevention programme delivered at scale ‘HENRY’: Effectiveness, cost-effectiveness and its role in obesity prevention within the wider complex system
Background: Childhood obesity disproportionately impacts those living in the highest levels of deprivation. COVID has had a profound effect on rates, where almost a third of childr...