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44,293 grants found
Showing 301 – 320 of 44,293 grants
The Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial: a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke
BACKGROUND: Stroke is the most common cause of death worldwide and the foremost cause of complex disability in the UK. Pneumonia causes more deaths after stroke than the neurologic...
Examining the benefit of graduated compression stockings in the Prevention of vEnous Thromboembolism in low-risk Surgical patients: a multicentre cluster randomised controlled trial (PETS Trial)
Research question: Are graduated compression stockings (GCS) effective in the reduction of hospital-acquired venous thromboembolism (VTE) in surgical patients undergoing short-stay...
Validation of a translatable chronobiological signature of early relapse in bipolar disorder
The aim of this multi-national project is to provide a quantum advance in understanding the mechanisms of sleep and circadian rhythm disruption amongst people with established bipo...
EXE
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because...
The effectiveness of Lithium plus Quetiapine COMBination versus LithIum versus QuetiapiNe monothErapy in the maintenance treatment of bipolaR disorder: the COMBINER trial.
Background: Bipolar disorder (BD) is a severe mood disorder characterised by episodes of hypomania / mania and depression. Maintenance treatment is critical to reducing the number...
Pregabalin for treatment resistant generalized anxiety disorder
Generalised anxiety disorder (GAD) is characterised by at least 6 months of symptoms including disproportionate worry, nervousness, poor concentration and sleep disturbance. GAD is...
Surveillance After Resection of Oesophageal aNd Gastric cancer (SARONG) trial
RESEARCH QUESTION: Does the routine use of a structured follow-up program with regular radiological and endoscopic investigations improve survival in patients who have had surgical...
Randomised Control Trial of fluoxetine for the treatment of problematic sexual arousal in adult males serving a custodial sentence for a sexual offence.
Primary research question: In men incarcerated for sexual offences who are referred for MMSA, fluoxetine prescribed over 6 months will be more effective in reducing problematic se...
ATTEND: (Adolescents and carers using mindfulness Therapy To END depression)
Research question Can a novel intervention, Mindfulness for Adolescents and Carers (MAC), improve recovery among young people (15-18 years-old) with depression who have failed to...
REvascularisation for heart failure with PReserved ejection fraction and Ischaemia: EValuation of Efficacy and mechanistic Description (REPRIEVED)
Research question Does percutaneous coronary intervention (PCI) improve quality of life by relieving ischaemia in patients with heart failure with a preserved ejection fraction...
Nutrition In Pre-School Children (NIPre) Study: the role of portion size, plant-based foods and commercially manufactured foods and drinks
Research question We will answer questions posed by the recent Scientific Advisory Committee on Nutrition (SACN) report: What are age-appropriate food and drink portion sizes i...
Randomised trial of the clinical and cost effectiveness of a supraglottic airway device versus tracheal intubation during in-hospital cardiac arrest (AIRWAYS-3)
RESEARCH QUESTION: In adults with in-hospital cardiac arrest (IHCA) does the use of a supraglottic airway (SGA), compared with tracheal intubation (TI), improve survival with a fav...
The ELIPSE Study - a randomised controlled trial comparing the clinical and cost-effectiveness of lymph node removal in patients undergoing curative surgery for localised high-risk prostate cancer.
Research Question Does Pelvic Lymph Node Dissection (PLND) provide better cancer control compared to no PLND in patients undergoing surgery (radical prostatectomy, RP) for locali...
A Randomised Double-Blind Placebo-Controlled Phase 3 Trial Of Triumeq In Amyotrophic Lateral Sclerosis
Research Question: Is the antiretroviral therapy Triumeq an effective treatment for amyotrophic lateral sclerosis (ALS)? Background: Amyotrophic lateral sclerosis(ALS), also k...
Developing environmentally sustainable operating theatres
Background Operating theatres contribute 25% of a hospital's carbon emissions. The NHS has committed to net-zero targets by 2045 but this cannot be achieved without reducing the c...
Rescue packs post-discharge in chronic obstructive pulmonary disease (The RAPID study)
Research question: Can rescue packs and a comprehensive self-supported management plan reduce readmissions following exacerbation of COPD? Background: Chronic obstructive pulmon...
Optimising Prescription of Treatment In older patients with Mild hypertension at Increased risk of Serious adverse Events (OPTIMISE2): a non-inferiority trial
Research question What is the effect of antihypertensive deprescribing on emergency hospital admissions and death in older adults at higher risk of adverse events? Background...
Landing Advances for a New Decade One "LANDOne"
LANDOne develops world-leading ambitious technologies to deliver the **next-generation landing-systems design**, manufacturing and assembly solution for the next generation **susta...
The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit / hyperactivity disorder and a history of Psychosis or biPolar disordER: SNAPPER
Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder involving inattention, hyperactivity and impulsivity that starts in childhood an...
Biomarker Driven Antifungal Stewardship (BioDriveAFS) in Acute Leukaemia – a Multi-Centre Randomised Controlled Trial to Assess Clinical and Cost Effectiveness
RESEARCH QUESTION Is biomarker-based antifungal stewardship (AFS) superior to prophylactic antifungal (AF) and standard of care (SoC) in reducing AF therapy use in patients wi...