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44,293 grants found
Showing 261 – 280 of 44,293 grants
Effectiveness and cost effectiveness of an automated text message intervention for weight management in postpartum women with overweight or obesity: the Supporting MumS (SMS) Randomised Controlled Trial
RESEARCH QUESTION: Does a fully automated text message intervention support weight loss and maintenance of weight loss in women with overweight or obesity who have had a baby in th...
Treating Oesophageal Atresia to prevent STricture (TOAST)
BACKGROUND: Babies born with oesophageal atresia (OA) are unable to feed unless they have a surgical intervention to join the two ends of the oesophagus. Following surgery, some su...
Climate Change and Child Malnutrition in Zimbabwe: Evidence to Action
Zimbabwe faces a significant burden of malnutrition: over a quarter of children under-five years are stunted. Although it is generally recognized that climate change can have profo...
Diagnostic accuracy of handheld ultrasound at 36 weeks of gestation to determine fetal presentation
Research question: What is the diagnostic accuracy of point of care ultrasound (PoCUS) for detecting breech presentation at term? Population: Women with singleton live pregnancy...
Developing, optimising and evaluating a conversion of standard smoking cessation support in pregnancy into a digital support package (eSupport)
Prenatal smoking is a key public health priority and major driver of health inequalities. Routine NHS support consists of interpersonal counselling with Nicotine Replacement Therap...
Visibilizing climate change impacts on nutrition and mental health among vulnerable populations in East African drylands to catalyse climate action at scale (Visibilize4ClimateAction in East Africa Project)
Climate change is a critical threat to the health of millions of vulnerable populations inhabiting the East African drylands. It affects the social and environmental determinants o...
Cholera control in endemic regions of Africa: assessing mass preventative OCV campaigns impacts and strategies
Cholera remains an important public health issue worldwide. Although OCV is recommended for use in cholera preventative control actions, much remains unknown on the vaccine perform...
Targeted Axillary Dissection versus axillary node clearance in patients with POsitive axillary Lymph nodes in Early breast cancer: A multicentre, pragmatic, phase III randomised controlled trial
RESEARCH QUESTION In breast cancer patients with low volume axillary nodal disease having primary surgery, compared with axillary node clearance (ANC), does targeted axillary diss...
Leveraging GLP1R and GIPR as molecular addresses for precision beta cell therapy/replacement during type 1 diabetes
One of the greatest challenges in type 1 diabetes (T1D) is ensuring function and survival of replacement beta cells. Rolling beta cell replacement out as an option for the majority...
Building a climate cohort to monitor health impacts of climate change in Ghana
Global health gains achieved over the past half century are being eroded by climate change. In low and middle-income countries, scientific and policy planning capacity to incorpora...
Clinical and cost-effectiveness of adapted online parent-led treatment compared to treatment as usual for autistic children with anxiety problems in Child and Adolescent Mental Health Services: A randomised controlled trial
Research questions (i) Is a therapist supported online parent-led intervention (OSI-A) non-inferior to treatment as usual (TAU) in reducing the impact of anxiety problems among au...
Potential climate change effects on food security, nutrition, and health of the Mexican population. Co-designing integrated policy measures
This project aims to address the multifaceted impacts of climate change on food security, nutrition, and health outcomes in Mexico. The project will focus on four aims: 1) assess g...
COMBAT: Clinical- and cost-effectiveness, safety and acceptability of COMBined phacovitrectomy, versus sequentiAl viTrectomy and cataract surgery, for the management of rhegmatogenous retinal detachment: A Randomised Equivalence Clinical Trial.
Research question: In people with non-highly myopic phakic rhegmatogenous retinal detachment (RRD) (Population) is phacovitrectomy (Intervention) equivalent (equivalence margin +/-...
Staphylococcus aureus Network Adaptive Platform (SNAP) Trial
The Staphylococcus aureus network adaptive platform (SNAP) trial investigates a range of antibiotic treatment options in S. aureus bacteraemia (SAB). Background: S. Aureus blood...
Southampton NIHR Biomedical Research Centre
Our vision is to enhance health and quality-of-life by improving resilience to disease, injury and the impacts of ageing. We will drive innovation through world-class research to u...
Randomised controlled trial of a new relief inhaler in mild asthma
Asthma is a common condition affecting approximately 10% of adults in the UK. Many people have relatively “mild” asthma, defined as requiring a short-acting beta-agonist (SABA) fo...
Improving quality of life and behaviour that challenges in people with mild to moderate intellectual disability through person-centred solution focused communication (ICONIC)
Research question Does adapted DIALOG+ reduce behaviour that challenges in people with mild and moderate intellectual disability by improving quality of life and is it cost effect...
Remote psychosocial interventions to prevent avoidable psychiatric hospital admissions in people with serious mental health problems: a multi-arm multi-stage trial
Research question Which brief, remote psychosocial interventions for people with Serious Mental Health Problems (SMHP) who report recent suicidal ideation or a suicide attempt are...
DAMPen-D II: Improving the Detection, Assessment, Management, and Prevention of Delirium in Palliative Care Units: a Cluster Randomised-Controlled Trial, Economic Analysis and Process Evaluation
BACKGROUND Delirium is highly distressing for patients and families, increases health professionals’ anxiety and stress, and leads to poor clinical outcomes and higher care costs....
Adjuvant radiotherapy in patients with high-risk primary cutaneous Squamous Cell Carcinoma AFTER surgery (SCC-AFTER): an open label, multicentre, two-arm phase III randomised trial
Research question Following complete excision of high-risk primary cutaneous squamous cell carcinoma (HR cSCC) is adjuvant radiotherapy (ART) plus active monitoring superior in re...