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44,293 grants found
Showing 241 – 260 of 44,293 grants
ESTEEM - Evaluating the clinical and cost-effectivenesS of TEstosteronE to improve Menopause-related quality of life
Research question: Is testosterone an effective and safe treatment for menopausal symptoms, beyond altered sexual function, when added to standard hormone replacement therapy (HRT)...
Out of Cycle NExt generation highly efficient air transport (ONEheart)
The 'Out of cycle NExt generation highly efficient air transport (ONEheart)' project will develop & test methods and capabilities to enable the accelerated development of optim...
Improving quality of life for people living with dementia and their care partners: the development, intervention and evaluation of a dementia specific narrative-based intervention: LEND (lived experiences narratives in dementia)
Background: In the UK, there are 850,000+ people with dementia supported by 700,000 informal carers. Both the diagnosis of dementia and the associated stigma can seriously undermin...
Enhanced Recovery After Critical Care (ERACC): Developing and Testing a Care Pathway for Patients Discharged From an Intensive Care Unit
RESEARCH QUESTION Can an evidence-based, theoretically driven, electronically-enabled, in-hospital Enhanced Recovery After Critical Care (ERACC) pathway increase hospital-free day...
BREATHE: Building Respiratory support in East Africa Through High flow versus low flow oxygen Evaluation
With this funding, we hope to achieve a decrease in mortality for the 20 million critically ill adults in sub-Saharan Africa with acute hypoxemic respiratory failure. In the settin...
Complex Multiple long-term conditions (MLTC) Phenotypes, Trends, and Endpoints (CoMPuTE)
Background Over 25% of adults in England have Multiple Long-Term Conditions (MLTC). Complex-MLTC (C-MLTC: 4 or more conditions) is more disabling, and is projected to increase fr...
Community Climate Health Amongst Livestock Keepers in Kyrgyzstan (CCHALKK)
This research project will advance evidence-based policy and practical actions to strengthen human health against adverse climate impacts within livestock- keeping communities (LKC...
Optimising cultural expeRIences for mental health in underrepresented younG people onlINe (ORIGIN)
Research question: Is an optimised, co-designed online intervention based on culture and the arts effective in reducing depression and anxiety in diverse young people (aged 16-24)?...
NIHR Leicester Biomedical Research Centre
The problem Common long-term conditions (LTCs), such as heart (cardiovascular), lung (respiratory) and metabolic (e.g. diabetes) diseases and cancer, are a serious challenge for pa...
A randomised, double-blind, placebo-controlled trial to evaluate the efficacy of orally administered Triiodothyronine (T3) for 24 weeks in patients with heart failure with reduced ejection (HFrEF) - TheT3-HF Trial
Research question: What is the effect of triiodothyronine (T3) supplementation on exercise tolerance in patients with heart failure with reduced ejection fraction (HFrEF) and low s...
The clock is ticking: A longitudinal multi-site study addressing teen sleep as a means to limit depression and anxiety
Adolescence is characterised by profound changes in brain development, sleep and circadian biology making this age group vulnerable to a variety of mental health challenges, which...
Safety of medications in pregnancy - a novel approach to improving shared decision making
Background: Medication use in pregnancy is common, yet current knowledge of the clinical risk/benefit and safety profiles of these medications remains very limited. As a result, m...
NIHR Nottingham University Hospitals NHS Trust CRF
The NIHR Nottingham Clinical Research Facility (CRF) was set up in 2017 to enable adults and children to take part in research that is the first step in testing new treatments. It...
Transitioning from Vulnerable to Vibrant: Building a Disaster Response Framework that Addresses Climate-Health Threats to Communities
Climate change impacts are exacerbating existing health and social inequities; this in turn increases the disproportionate health burden for vulnerable communities who already expe...
Measuring Impact and Effectiveness of Cholera Vaccines in Uvira, Democratic Republic of the Congo
We will leverage a robust cholera research platform in the city of Uvira, Democratic Republic of Congo to estimate the effectiveness and impact of a cholera vaccination program, pr...
Bronchiectasis: Optimising Azithromycin prevention Treatment to reduce exacerbations (BOAT): A double blind pragmatic randomised controlled trial
Background: Prophylactic azithromycin is recommended to reduce the risk of respiratory exacerbations in people with Bronchiectasis. There is much uncertainty in how to optimally us...
ENHANCE-D - Enhancing Dental Health Advice
Smoking remains one of the principal risk factors for oral diseases, specifically periodontitis and oral cancer/pre-cancer. Dental professionals currently offer very brief advice (...
Should we use post-operative antibiotics following surgery for patients with mandible fractures? The MANTRA trial (MANdibular TRauma and Antibiotic use)
Research Question: Are post-operative antibiotics required following surgery for patients with mandible fractures? Background: Mandible fractures are the commonest facial fractur...
Evaluation of PeRsOnalised PrEhabilitation in acute myeloid Leukaemia (PROPEL)
BACKGROUND Acute myeloid leukaemia (AML) is the most common acute leukaemia; 5-year survival in adults is around 20%. Treatment aimed at cure requires multiple courses of intensiv...
Understanding intergenerational transmission of poor cardiovascular health in Africa (GenHeart Study)
People of African descent have increased risk for hypertension, stroke, and hypertensive disorders in pregnancy. This poor cardiovascular health is in part heritable. Across three...