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44,293 grants found
Showing 221 – 240 of 44,293 grants
REFRESH study: nutRition intervEntions For malnouRished oldEr adultS in care Homes - A parallel, superiority, three-arm cluster randomised controlled trial.
Research question In older adults with or at risk of malnutrition living in care homes, what is the clinical- and cost-effectiveness of oral nutritional supplements (ONS) and fort...
Bicarbonate for AcidosiS in very pretErm babies: a randomised clinical trial: The BASE Trial
Background: Sodium bicarbonate (SB) is widely, but not universally, used to treat metabolic acidosis (MA) in very preterm (VPT) babies but the evidence underpinning its use is poor...
Bracing Adolescent Idiopathic ScoliosIS (BASIS) Study – night-time versus full-time bracing in adolescent idiopathic scoliosis.
Primary research question: Is night-time bracing (NTB) non-inferior to full-time bracing (FTB) in preventing curve progression to 50 degrees or more in children with adolescent idi...
Community-based ear and hearing care
Research question: How can we best enable community-based ear and hearing care? Background: Ear disease and hearing loss are prevalent and under-recognised disorders, with 80...
ZEST1 Zero Emissions for Sustainable Transport 1
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because...
DTP 2224 University of Oxford
Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils. For information on current funding routes, see the common terminology at https:...
Uniting the sector to make R&D; matter to more people
A thriving research and development (R&D) sector is essential for improving lives and livelihoods. ‘Betting big’ on R&D for the UK’s future prosperity will mean a succession of har...
Randomised controlled trial evaluating effectiveness of neoadjuvant endocrine treatment in post-menopausal women (EndoNET)
HYPOTHESIS: Neoadjuvant endocrine therapy (NET) reduces breast cancer (BrCa) size prior to surgery, reducing surgical burden leading to better health-related quality of life (HRQoL...
The development and evaluation of two Prehab interventions for patients undergoing elective and urgent heart surgery
Research questions In people undergoing elective cardiac surgery, is prehabilitation effective and cost-effective? In people undergoing urgent cardiac surgery, is prehabilitati...
Reducing risk of cardiovascular disease in people with severe mental illness: co-production, feasibility testing and trial of a peer supported group clinic intervention (PEGASUS)
Research question Can a peer-supported, group clinic intervention reduce risk of cardiovascular disease (CVD) in people with severe mental illness (SMI) at enhanced CVD risk? Bac...
A Randomised Controlled Trial of Renin-Angiotensin System Inhibition for Reduction of Cardiovascular Events after Takotsubo Cardiomyopathy (EVEREST)
1) Research question. Does renin-angiotensin system inhibition (RAS inhibition) reduce recurrent cardiovascular events and improve quality of life in patients after acute takotsubo...
Pre-hospitAl Randomised triAl of MEDICation route in out-of-hospital cardiac arrest (PARAMEDIC3)
RESEARCH QUESTION: Population: Adults with out-of-hospital cardiac arrest Intervention: Intraosseous (IO) first strategy Comparator: Current NHS treatment (2 attempts a...
Defining, Recognising and Escalating Maternal Early Deterioration (DREaMED):Decreasing inequality through improved outcomes
RESEARCH QUESTION Can an electronically-embedded, data-enhanced Modified Obstetric Early Warning Score (eMOEWS) with behaviourally-informed escalation pathways prevent maternal n...
Deciphering neuronal RBP regulation of mRNA transport and translation in synaptic plasticity
At brain synapses, the direct functional connection between neurons, RNA localization and local regulation of protein synthesis are critical components for sculpting the synaptic p...
LACunar Intervention (LACI) Trial-3: Assessment of efficacy and safety of cilostazol and isosorbide mononitrate to prevent adverse outcomes in patients with cerebral small vessel disease (lacunar) ischaemic stroke
Research question: Do oral isosorbide mononitrate (ISMN) and/or cilostazol, prevent cognitive impairment, dependency, adverse vascular outcomes, death, and improve quality of life,...
Optimising outcomes in pregnant women with epilepsy and their babies: Reducing maternal seizure risks and assessing long-term safety of antiepileptic drugs
RESEARCH QUESTIONS In pregnant women with epilepsy, can implementation of an evidence-based intervention with structured risk assessment (Epi-Safe) improve care than curr...
Make Data Count: A Central Corpus for All Data Citations
To articulate the value proposition and justify open science as a norm in the research community, it is necessary to assess the impact and reach of investments made in open researc...
PravastatIn tO preveNt prEtErm biRth (PIONEER): a parallel group randomised placebo-controlled trial
Research question: 1)Is Pravastatin better than placebo at extending gestational length of pregnancy? 2)If so, does Pravastatin have this effect through changes to the cervicovagin...
Air Filtration to reduce Respiratory Infections (including COVID-19) in care homes: the AFRI-c cluster randomised controlled trial with nested internal pilot, process and economic evaluations
Aim: The overall aim is to investigate the clinical and cost effectiveness of portable HEPA air filters in reducing symptomatic winter respiratory infections (including COVID-19)...
Treating persecutory delusions successfully: enabling patients with psychosis to receive the most effective psychological therapy
Background: Persecutory delusions are one of the most severe mental health problems. We have developed a highly effective, theoretically driven cognitive therapy (the Feeling Safe...