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44,293 grants found
Showing 201 – 220 of 44,293 grants
Benefit-risk of TB prevention treatment for people with diabetes
Ending TB requires accelerated effort to intervene in people with TB-associated multimorbidity. Diabetes affects millions in poor countries and increases the risk of TB. Antibiotic...
Combination chemotherapy versus Bacillus Calmette-Guérin (BCG) for high-risk non-muscle invasive bladder cancer– a phase III multi-centre randomised controlled trial (COBRA)
Research question Are adjuvant intravesical gemcitabine and docetaxel (Gem-Doce) bladder instillations non-inferior to Bacillus Calmette-Guérin (BCG) in terms of high grade recurr...
A Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) - Influenza
-Research questions Overall platform: What are the most clinically and cost-effective pharmaceutical interventions for patients of all ages hospitalised with confirmed influenza?...
Optimising the delivery of Diabetes Distress informed care for its prevention, detection, and management in adults with type 1 diabetes: a hybrid effectiveness – implementation programme (D-Stress study)
Background Almost half of adults with type 1 diabetes experience elevated diabetes distress. Diabetes distress is experienced when a person feels burdened or overwhelmed by livin...
Addressing the Commercial Determinants of Health in Sub-Saharan Africa
Background: The global health, social and economic burdens arising from non-communicable diseases (NCDs) and the climate crisis are characterised by inequalities within and between...
Through knee Amputations impact on Quality of Life compared to Above Knee Amputations - The HAMLET Trial
Research question: Does a through knee amputation (TKA) confer a quality of life (QoL) advantage over an above knee amputation (AKA) for patients requiring a major lower limb amput...
Tracking the impacts of climate change on maternal and child health: the Global Heat Attribution Project (GHAP)
Detection and attribution studies isolate health impacts specific to climate change, spotlighting the growing health, and socio-economic consequences of climate inaction, providing...
The EVIDA Initiative: Strengthening Evidence-informed Vaccine and Immunization Decision-making and Appraisal in Low-and Middle-Income Countries
The EVIDA Initiative of the WHO Regional office of the Americas (PAHO) is a 3-year proposed scope of work to 1) support NITAGs and national immunization programs (NIPs) in Latin Am...
Optimising azithromycin prevention treatment in COPD to reduce exacerbations (OPACE)
BACKGROUND Prophylactic azithromycin is recommended as a treatment to reduce the risk of COPD exacerbations in people with COPD, at high risk of exacerbations. There is much unce...
The 4th Multicentre Intrapleural Sepsis Trial (MIST4) - a definitive randomised clinical effectiveness study comparing initial video assisted thoracic surgery and intrapleural enzyme therapy in adult patients with pleural infection.
Research question Is Video Assisted Thoracoscopic Surgery (VATS) superior to Intrapleural Enzyme Therapy (IET) in the initial treatment of adult patients with pleural infection?...
Preterm pre-eclampsiA: PlAcental Growth factor testing for reduction of Adverse Outcomes
The PAPAGAIO Global Health Research Group is focused on reducing maternal and perinatal mortality and morbidity from pre-eclampsia, across low- and middle-income countries (LMICs)...
Stratification of Clinically Vulnerable People for COVID-19 Risk Using Antibody Testing (STRAVINSKY)
Background: Although the COVID-19 vaccination program has proved extraordinarily successful, clinically vulnerable (CV) patients remain at risk of SARS-CoV-2 infection, severe COVI...
Climate and Health Data Capacity Accelerator
To transform the social impact sector and enable it to truly benefit from the data revolution, we must address how we educate, train, and upskill social impact talent. data.org is...
Community Health Intervention through Musical Engagement (CHIME) for Maternal Mental Health
Poor maternal mental health is a major global health challenge. Affecting up to one in five women, mental health conditions during and after pregnancy can have long-term adverse ef...
Net Zero Teesside Onshore
The Net Zero Teesside project, together with its associated Transportation and Storage project, the Northern Endurance Partnership, create a pathway to facilitate decarbonisation o...
Towards sleep and circadian diagnostic biomarkers for unipolar and bipolar depression
Altered sleep and circadian rhythms are common clinical features of both unipolar depression (major depressive disorder, MDD) and bipolar disorder (BD). Nonetheless, major knowledg...
NIHR Global Health Research Group on Zoonotic Causes of Acute Febrile Illness (GHRG-ZAFI)
Acute febrile illnesses (AFI) account for 40% of child deaths in sub-Saharan Africa, and an unknown level of morbidity and mortality in adults. Growing awareness of the animal orig...
The Identification of Medication Adherence Barriers Questionnaire intervention (IMAB-Qi): Developing a package to support IMAB-Qi delivery in general practice and a trial to test IMAB-Qi effectiveness and cost-effectiveness
Background Half of patients do not adhere to prescribed medication directions. Patients and Health Care Professionals (HCPs) struggle to identify a patient s main barriers to adh...
POCUS4TB: NIHR Global Health Group on AI-assisted point-of-care ultrasound (AI-POCUS) for TB screening
The Aim of this Global Health Research group is to develop and test an artificial intelligence (AI)-supported point-of-care ultrasound (AI-POCUS) to improve the reach and quality o...
The Bradford Mental Health Collaboratory: an efficient platform for evaluating interventions to improve adolescent mental health
Adolescent mental health problems are a major public health concern, and epidemiological evidence suggests that prevalence is increasing in the UK. However, there is limited good q...