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15,626 grants found
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Interplay between co-stimulatory signalling and extracellular matrix in atherosclerotic plaque stabilization
BACKGROUND The main underlying cause of cardiovascular disease (CVD) is atherosclerosis: inflamed plaques in the blood vessels that can cause stroke or myocardial infarction upon...
Intermunicipal cooperation - an appropriate response to local government austerity?
Intermunicipal cooperation (IMC) has become increasingly common across Europe. Decision-makers - on both central and local levels - have come to appreciate IMC as an effective answ...
Type 1 Diabetes and Enviromental Factors
Aims: To exploit Sweden’s exceptional systems to link the highly granular national GIS (geographic information system) and assess in detail i) the environmental variability in Type...
PERSONALIZED PREVENTION AND TREATMENT OF SEX STEROID-DEPENDENT SCLEROTIC BONE METASTASES IN PROSTATE CANCER
Prostate cancer (PCa) is the most common cancer in Sweden. While the local disease is rarely lethal, the 5-year survival of patients with metastatic disease is only about 30%. PCa...
Pediatric hypo- and low- glycemia in low income countries - how can treatment be optimised?
Severely ill children with low blood glucose values in resource poor setting suffer a three to four-fold higher risk of mortality compared to children with normal blood glucose. Th...
The gut environment as instructor of immunity and allergy development
The human immune system is remarkably well developed at birth, but continues to mature during early years. This early period will imprint immune function and thereby influences our...
FACES: Facial Activities of Compound Emotional States of horses
Facial expressions (FE) of pain are widely used for assessment pain in horses. However, FE of e.g. stress may go unnoticed in pain scorings, as shown in pilot studies of FE of stre...
Prevention of bone loss by modulation of estrogen signaling
Fractures caused by bone loss are associated with suffering and increased mortality in patients and great costs for society. It is well established that estrogen protects the skele...
Immune reactions in patients with metastatic breast cancer
Purpose and Aim: To study the mechanism behind how the innate immune system in late stage cancer patients is suppressed, with consequences and how to restore it.Survey of the field...
Social safety signals – Neurodevelopmental dynamics of social threat regulation
Threat- and anxiety related disorders limit the life of millions of people around the world. Experimental research has focused on understanding dysfunctions in the neural threat ci...
Gendered place identities and politics of belonging: An ethnographic study of the success and the boundaries of ethnonationalist expansion in three Swedish regions
Scholarship has shown that there are significant regional variations in the political support for radical right parties in Europe and Sweden, and there is diversity in the regional...
Optimizing strategies for assessment and management of limb muscle dysfunction in COPD: Why is it important, and how should it be done?
BACKGROUND: Chronic obstructive pulmonary disease (COPD), currently the third leading cause of mortality worldwide, is a multisystemic disease in which limb muscle dysfunction, is...
Plant based meat products for treatment of iron deficiency
Iron deficiency is the most common global nutritional disorder. It is the only nutrient deficiency that is not only prevalent in non-industrialized nations, but also in almost all...
Mapping protein nanoenvironments
Super-resolution imaging has revealed that most proteins at the plasma membrane are not uniformly distributed but localize to domains of nanoscale dimensions. The composition and s...
Inverkan av behandling med konstdjord lunga (extrakorporal membranoxygenering) på kärlmotståndet i lungkretsloppet och höger hjärtkammarens funtkion hos grisar.
Bakgrund: During severe hypoxaemic respiratory failure, e.g. severe ARDS, increased pulmonary vascular resistance (PVR) may partially be caused by hypoxic pulmonary vasoconstrictio...
Sustainable enzymatic production of chemicals through novel concept of particle stabilized emulsions
The transition from fossil to a sustainable bio-based economy is arguably the most important challenge we face today, due to the urgent need of slowing down the ongoing climate cha...
The interplay between lipid handling, inflammation and autophagy: Implications for cardiovascular disease and longevity
BackgroundAutophagy is a conserved self-protecting process involved in lipid handling and inflammation but the role in the pathogenesis of cardiovascular complications in type 2 di...
Solar cells on trucks for environmental friendly transport
Purpose and goal: The main purpose of the project was to show how solar cells can be used in truck based transports to reduce CO2 emissions and in the project the main objective w...
Methylation of Mercury in Thawing Permafrost Soils Across the Circumpolar North
Temperatures of permafrost soils have increased by 0.39 ± 0.15°C in zones with continuous permafrost during the last decade (IPCC report on The Ocean and Cryosphere in a Changing C...
Neural markers of skill learning - a longitudinal twin study
Human skill learning depends on a complex interplay between practice, genes, and the environment. Here, we perform the first longitudinal study of the neural basis of skill learnin...