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15,626 grants found
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Drinking water and public health: the importance and handling of drinking water-related exposures in Sweden
Access to safe drinking water is a human right, indispensable for health. Drinking water of adequate quality is relatively easy to produce in Sweden. Yet, the system is vulnerable...
Exploiting the tumor-suppressing enzyme AHCY to target methionine-dependent cancer
A wide variety of cancer cells strictly require the amino acid methionine to survive and grow, while normal cells do not. This is being exploited to treat cancer by methionine star...
Genome dynamics in livestock breeding: how the features of the genome affect breeding
This project will improve our understanding of how the features of the genome affect breeding by combining genome analysis of cattle, pigs, and chickens with genetic simulation, us...
Genetic and protein biomarkers for risk and severity of multiple sclerosis
Aim and importanceIdentify genetic variants and lifestyle exposures associated with progression and severity of multiple sclerosis (MS) leading to an understanding of biological pr...
Saving the maternal brain
Purpose and aims: Preeclampsia occurs in 3% of all pregnancies and is a leading cause of maternal morbidity and mortality worldwide, where cerebral injury is among the most common...
Therapeutic implications of bioactive nitrogen oxides in the triad of reno-cardio-metabolic disorders
BACKGROUND: Cardiovascular, metabolic and renal disorders are closely coupled and have major impact on global health. Oxidative stress and impaired function of the nitric oxide (NO...
The Scania enigma and geographies of solidarity: Place identities in the shadow of growing ethno-nationalism
The project focusses on the Sweden Democrats (SD) and the role of local and regional gendered place identities in contributing to the regional strength of ethno-nationalism, but al...
Novel integration of coronary atherosclerosis imaging with physiologic features for optimized risk stratification of patients with coronary artery disease.
Background: This project seeks to integrate coronary atherosclerosis with coronary pathophysiologic features to improve identification of stable individuals who will subsequently...
Data-driven multiscale modeling and simulation of the striatum
The research goal is to delineate the subcellular and cellular/network mechanisms underlying striatal involvement in selection of behaviour and reward learning. This research is si...
Impact of Combined Exposures on Metabolic Health (ICE)
Exposures such as diet, gut microbiota and environmental pollutants are recognized as major determinants of health and non-communicable diseases (NCD). NCDs are the leading causes...
Cell therapy for improved post-stroke functional recovery
Ischemic stroke is an acute insult leading to death of brain cells. A majority of stroke survivors exhibit different degrees of functional impairments. Apart from thrombolysis and...
Biological signature and efficacy of mesenchymal stem cell-based therapies
Vast efforts have been put towards developing mesenchymal stem cell (MSC) therapy for various disorders. However, obstacles exist due to undefined mechanisms of action and difficul...
Prosocial regulation of intergroup relations through moral exemplars: From mechanism to real-life behaviour
Our social perceptions spontaneously divide people into “us” and “them”. In addition, we often believe that “we” are better than “them”. Such perceptions lead to prejudices, intole...
Development of a novel in situ sequencing technique for mapping of genes, circuits, and repair in the human brain
The translation of experimental findings in neuroscience, from advanced human cell systems (in vitro and in vivo) to and from the clinic, is still a significant hurdle. Place, phen...
Holistic insights into the sources, distribution, exposure and temporal trends of chlorinated paraffins in the indoor environment
Chlorinated paraffins (CPs) is a group of complex chemical mixture containing millions of theoretical homologues and isomers and are ubiquitous environment due to their large produ...
Genetic and epigenetic studies of pediatric acute leukemia
Genetic and epigenetic analyses of acute lymphoblastic and myeloid leukemias (ALL, AML) have identified pathogenetically important mutations and/or epigenetic changes that have res...
Getting to grips with the etiology of digital dermatitis
Digital dermatitis (DD) is a painful disease of the feet of intensively managed cattle. DD is a leading cause of lameness, associated with large economic losses due to decreased re...
THE TRAP5/OSTEOPONTIN-AXIS – A NOVEL TARGET TO TREAT AIRWAY INFLAMMATION
Chronic airway inflammation results in tissue injury, remodeling, and, in severe cases, respiratory failure. This is exemplified by COPD and non-allergic asthma where current treat...
Too much data? Gaming, addiction and health for children and adolescents.
Gaming is one of the most common activities among children and adolescents in Sweden. There is an ongoing debate among the general public, and in the research community about possi...
Testing a new hypothesis for neurobiology of gender dysphoria across various gender identities
The concept of gender identity is target for great attention, as there is a trend among young adults to define themselves as nonbinary (NB), and the requests for sex-assigning trea...