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15,626 grants found
Showing 481 – 500 of 15,626 grants
Unlocking and blocking the molecular mechanisms of redox regulation in β-cells
The islets of Langerhans are the endocrine component of the pancreas and their dysfunction, in particular the β-cells, results diabetes. Currently there is no cure for diabetes. Th...
Evaluation and individualization of colorectal cancer screening in Sweden (The EVIDENCE project)
Colorectal cancer (CRC) is the third most common cancer worldwide and the most resource consuming and costly cancer. Primary and secondary prevention of CRC with screening can redu...
Harnessing DNA Replication Stress to Overcome Treatment Resistance of high-risk Cancers
The landscape of precision medicine in cancer is on the brink of a profound shift, propelled by rapid advancements in next-generation anticancer drugs, including immuno-oncology (I...
Goblet cell intrinsic determinanats of intestinal mucus function in health and disease
Non-communicable intestinal mucosal diseases affect millions of people and are expected to rise in prevalence due to the impacts of modern lifestyle changes. Common to these diseas...
Nutritional metabolomics: capturing habitual diet patterns and their relation to health outcomes in the population.
The program goal is to use nutritional metabolomics to objectively describe intake of major food groups in healthy diets, combined with self-reported intake, among individuals in l...
Tissue resident lymphocytes in severe asthma and biologics treatment
Biologics targeting type 2 cytokines offer new hope for patients with severe asthma, but not all patients respond, and none are cured. This calls for increased understanding of air...
Charting the complex molecular landscape in chronic lymphocytic leukemia: the path towards precision medicine
The proposed project aims to thoroughly map the molecular landscape of chronic lymphocytic leukemia (CLL), the most prevalent adult leukemia in Western countries. Taking advantage...
Translational studies on SAMHD1 as resistance factor, tumour suppressor, and regulator of immune responses
Our overarching goal is to rationally improve cancer treatments. To this end, we study the key cancer protein SAMHD1 that has context-dependent roles for treatment resistance, tumo...
Psychobiological markers to improve diagnosis and to predict affective episodes in bipolar disorder
There is an urgent need for better tools to improve and facilitate diagnosis of bipolar disorder and to detect and prevent affective episodes at the earliest possible stage. We hyp...
Innovative biomaterials and methods targeting corneal blindness
The cornea is the eye´s outermost transparent window, and maintenance of its transparency and shape are essential for vision. Degenerative, age-related and uncorrected refractive c...
Den genetiska grunden för överföring av malariaparasiter: förstå oocystans kritiska roll.
The transmission of Plasmodium parasites by mosquitoes is a major target to reduce the global burden of malaria. It relies on the coordinated developmental cycles of mosquito repro...
Reduction and refinement of mouse usage with in utero engineered mouse models
Genetically engineered mice are the current state of the art for understanding gene function, lineage tracing studies, and more. However, these mouse models entail by-production of...
Optimizing outcome and improving accessibility to psychological treatment for adolescent self-injury: randomized controlled trial
Self-injury is a growing health crisis among youth, and the strongest risk factor for suicide attempts. Scalable treatments are needed but lacking. We have recently shown that a br...
Next generation vascular targeting for brain tumors
Glioblastomas are aggressive gliomas characterised by an extreme invasiveness and dysfunctional vessels. The abnormal vessels promote tumor progression (1) by providing a route of...
Epidemiological and single-cell transcriptomic studies on the effects of vitamin A and inflammation on bone health
The overall aims of this project is to understand how vitamin A and inflammatory processes affect bone mass. Increased levels of vitamin A are considered a risk factor for secondar...
Boosting the Intestinal Mucosal Barrier to Emerging Pathobionts in Patients with Crohn´s Disease
Crohn´s disease (CD) is one of the main chronic inflammatory bowel diseases, with significant impacts on patients´ quality of life. Current treatments lack therapeutic precision, c...
The paths of MS – data-driven personalized prediction of multiple sclerosis risk and disease-modifying treatment outcomes
Multiple sclerosis (MS), a chronic inflammatory and neurodegenerative condition, is a major driver of disability and healthcare costs among young to middle-aged adults. Access to d...
GLP-1 Receptor Agonists and Other Pharmacotherapy for Type 2 Diabetes and Obesity: Use and Safety in Pregnancy
Semaglutide and other GLP-1 receptor agonists (GLP-1 RA) have revolutionized the treatment of type 2 diabetes and obesity and their use in Sweden and globally has increased dramati...
TeamBirth and intervention to improve patient safety and person-centered care during childbirth
Most adverse events within maternity care stem from communication and teamwork failures. Despite national and international recommendations, few interventions include person-center...
Remaining pain in rheumatoid arthritis – Therapeutic performance of different biological treatments and clinical relevance of a recently identified unexplored causative signalling pathway.
Pain in rheumatoid arthritis (RA) is highly debilitating, impacts quality of life and lacks adequate treatment options. Although biologics have proven benefits on inflammatory dise...