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15,626 grants found
Showing 461 – 480 of 15,626 grants
The significance of environmental and lifestyle factors for the onset and course of multiple sclerosis.
Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults in Europe. The etiology is unclear. Twin studies suggest that environment and/...
BEAM-MS - Brain-resident cell Epigenetics Altered by the Metabolome to target Multiple Sclerosis
Multiple Sclerosis (MS) is a major neurological disorder, characterized by the loss of myelin around nerve axons in the central nervous system due to autoimmune attacks. Oligodendr...
To find the cause of rheumatoid arthritis using humanized mouse models with the major polymorphic genes; HLA-DR and NCF1
Purpose and objective: Investigate the cause of rheumatoid arthritis (RA) using unique mouse strains expressing the major disease-associated human alleles (DRB1 and NCF1) to develo...
IL-6 trans-signalling in HPS and HFRS pathogenesis: a treatable target?
Hantaviruses cause two severe acute diseases; hantavirus pulmonary syndrome (HPS), and hemorrhagic fever with renal syndrome (HFRS). Fatality rates are 35-40% for HPS and up to 10%...
Pathogenic mechanisms and effects of treatment in chronic, idiopathic inflammatory myopathies, myositis
Myositis is a complex autoimmune disease with high morbidity and mortality. Biomarkers to predict prognosis are lacking. Newly discovered myositis specific autoantibodies predict d...
Understanding how MYC drives transcriptional amplification via regulation of DNA topology
Inhibitors of Topoisomerases (TOPs, TOP1, TOP2) are mainstays of anticancer therapy. While they have proven effective, the toxicity of current TOP drugs in non-cancer cells, limits...
Towards personalized medicine in pregnancy: Early prediction of pregnancy complications to improve maternal and fetal outcomes
Purpose. The existing antenatal care program is similar for most women with increasing frequency of visits as the pregnancy progresses, aiming to find established pregnancy complic...
Unravelling the Molecular Signatures of Reproductive Mood Disorders: a Multi-Omics Approach Project
The MoodMAP project targets the challenge of diagnosing and treating reproductive mood disorders (RMDs), such as premenstrual disorder and postpartum depression, which significantl...
´Stronger Together´ - Psychological support for parents of children diagnosed with cancer
Parents of children with cancer report increased levels of psychological and relationship distress. Yet, there is a lack of interventions in paediatric oncology care addressing the...
Platform development of engineered extracellular vesicles for gene editing in the CNS
To date, there are no curative treatments for most neurodegenerative disorders, including synucleinopathies of the central nervous system (CNS) such as Parkinsons disease (PD). The...
Impact of Collective Chemical Exposome of Infertile Couples on the Likelihood of Clinical Pregnancy and Live Birth
Infertility affects 15-20% of all couples during their reproductive lifespans and is a significant couple and public health problem. Despite advanced techniques to address infertil...
Environment before adulthood in Multiple Sclerosis etiology
Through Swedish multiple sclerosis (MS) registers and microbiological biobanks crosslink, we have formed the world´s largest material with pre-symptomatically drawn serum samples....
Regulation of nuclear processes by mast cell tryptase - molecular mechanisms and disease implications
Mast cells (MCs) are versatile immune cells mostly known for their detrimental actions in allergic disease, but they have also been implicated in a range of other pathological sett...
Defining persisting brain injury after eclampsia and identifying new treatment targets to protect the maternal brain
The goal of this project is to define neurological outcomes after eclampsia and to determine underlying pathophysiological pathways to eclampsia which will lead to new drugs for ne...
Medication-wide surveillance of pregnancy drug safety in large-scale real-world data: systematic generation of missing evidence to inform clinical decision-making
Most prescription drugs lack enough evidence on their safety for use during pregnancy. Our overall aim is to systematically gather new evidence for the safety of a comprehensive ra...
A Comprehensive Molecular Map of Human Ovaries Across Life Stages for the Development of Novel Fertility and Ovarian Reserve Markers
Human fertility rates have declined below the population replacement rate in every EU member state, with the age of first-time mothers increasing to 30 years. Maternal age signific...
Is being overweight early in life a risk factor for early diagnosis of type 1 diabetes in children and, if so, does it explain the increase in T1D incidence during the Covid pandemic?
Type 1 diabetes (T1D) is one of the most common disease among children in Sweden and the incidence has doubled in recent decades. Numerous studies have reported an even higher inci...
From Mice to Patients: Preventing Joint Destruction with Anti-RANKL in Septic Arthritis
Septic arthritis presents a significant challenge in modern medicine, often leading to permanent joint dysfunction and necessitating joint replacement surgery. Our hypothesis focus...
Strategies for countering treatment resistance in cancer by tracing and targeting clonal dynamics
Rationale: Most children dying from cancer under modern healthcare do so because of relapsing, treatment-resistant disease. The mechanisms underlying resistance are largely unexplo...
Countering stigma in self-management in people with chronic obstructive pulmonary disease: co-creation and feasibility of an intervention to improve health
People with chronic obstructive pulmonary disease, COPD, are often stigmatized due to previous long-term smoking. Stigma has been highlighted as a barrier to self-management. Still...