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Apply novel pathogenomic approaches to identify interpretable image QTLs for multiple normal tissues
ABSTRACT The overarching goal of this project is to identify tissue-specific genetic variants and genes that are associated with cellular and tissue morphology in normal tissues. W...
meQTL Discovery in Admixed Human Genomes Facilitates Estimates of Epistasis
Personalized genetics is poised to revolutionize healthcare; however, despite advances, genetic prediction and portability of critical variants remains too limited for clinical use...
AI-MedWise: Developing and validating an artificial intelligence solution for effective video-based monitoring of medication adherence
PROJECT SUMMARY Poor adherence to oral medications is highly prevalent in 40-50% of patients with chronic diseases worldwide.Close monitoring of medication adherence is a critical...
Resistant starch treatment of polycystic ovary syndrome: impact on cardiometabolic dysfunction and the gut microbiome
Hyperandrogenic women with polycystic ovary syndrome (PCOS) have a high prevalence of cardiovascular disease (CVD) risk factors including obesity, insulin resistance, hypertension,...
Skin-interfaced triboelectric sensors continuously monitor worker forceexertions to prevent workplace injuries
Abstract Despite advances in automation, manual material handling (MMH) tasks continue to be commonplace in the workplace. To design and control the high burden of musculoskeletal...
Structure-based antisense therapeutics targeting dystrophin exons 44 and 45 for Duchenne Muscular Dystrophy
Project Summary Duchenne muscular dystrophy (DMD) is a lethal pediatric neuromuscular disorder that affects 1/5000 boys globally. This rare disease is caused by mutations in the ge...
Using Large Language Models to identify social determinants of health to enhance healthcare services and equity
PROJECT SUMMARY/ABSTRACT Social determinants of health are known to have a significant impact on patient outcomes. However, controversies exist on how to best capture this informat...
Optimizing an integrated passive body heating and behavioral intervention for insomnia
PROJECT SUMMARY/ABSTRACTInsomnia disorder is a common and consequential mental health problem, with prevalence estimates at approximately 10%. The American College of Physicians re...
Building Mood State Classifiers to Inform Deep Brain Stimulation (DBS) of Treatment-Resistant Bipolar Depression
Bipolar Disorder (BD) is a recurrent neuropsychiatric disorder characterized by wide fluctuations in mood, energy, and activity.Although the hallmark of BD is mania in BD-I (hypoma...
Heat therapy to improve functional performance in Heart Failure with Preserved Ejection Fraction
PROJECT SUMMARY Heart failure with preserved ejection fraction (HFpEF) is a debilitating disease with high morbidity, mortality and health care expenditures. Impaired physical capa...
Deep Learning-based Diagnosis of Retinopathy of Prematurity
Project Summary Retinopathy of prematurity (ROP) is a leading yet largely preventable cause of childhood blindness globally. There is an unmet need for timely and consistent diagno...
Promoting a reparative instead of a degenerative outcome from loading of fatigue-damaged tendons
Tendinopathies are common injuries that typically result from accumulation of sub-rupture fatigue damage. We have developed an in vivo model of sub-rupture fatigue damage accumulat...
Clinical assessment of radiotherapy-induced vaginal toxicity with multiparametric ultrasound imaging
PROJECT SUMMARY/ABSTRACT Pelvic radiotherapy is the standard of care for numerous gynecological and anorectal cancers affecting women. Post-operative intravaginal brachytherapy (IV...
How cerebrospinal fluid (CSF) potassium supports brain development and activity
PROJECT SUMMARY/ ABSTRACT The brain and spinal cord are filled with and surrounded by a complex fluid, the cerebrospinal fluid (CSF). CSF directly contacts brain progenitors to act...
Mechanisms required to compartmentalize the stem cell niche during organogenesis.
Project Summary/Abstract: Stem cells are required for tissue homeostasis and regeneration. Accomplishing these tasks often requires intimate association between stem cells and thei...
Peptide cues in the environment regulate bacterial dormancy
PROJECT SUMMARY Bacterial cells communicate through the language of molecular cues that are released into the environment and detected by cells in nearby communities. While prevale...
Probing the potential role of the Rieske protein in superoxide formation in Complex III
Abstract Reactive Oxygen Species include molecules such as superoxide, peroxide and hydroxyl radicals. High levels of these molecules have been shown to lead to diseases such as he...
MitoNEET is a Regulator of the Cellular Thiol State in Health and Disease
PROJECT SUMMARY MitoNEET is a druggable target, with recognized roles in type-2 diabetes, cancer, and Parkinson’s Disease. The redox-active [2Fe-2S] cluster of mitoNEET, localized...
Investigating common luminophore in protein-metal nano-complexes
ABSTRACT Biomaterials with luminescence in the visible wavelengths are the indispensable tool of biological research today. A new class of luminescent protein material, protein-gol...
A design strategy to quantify unconjugated Nedd8 using genetically encoded sensors.
PROJECT SUMMARY/ABSTRACT Genetically encoded sensors that can detect and quantify proteins and other ligands are useful tools for studies of target dynamics and biomedical applicat...