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99,167 grants found
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Core 1: Protein Biochemistry and Enzymology (PBE) Core
ABSTRACT DNA double-strand breaks (DSB)s are eliminated primarily through two mechanistically distinct pathways, namely, non-homologous DNA end joining (NHEJ) and homology-directed...
Core 2: Chromosome Replication and Analysis (CRA) Core
ABSTRACT Failure to properly repair DNA double-strand breaks (DSBs) or damaged DNA replication forks leads to chromosome aberrations and neoplastic transformation of cells. Homolog...
Core 3: Structural Biology and Biophysics (SBB) Core
ABSTRACT The Structural Biology and Biophysics (SBB) Core will provide Program Project Investigators with high-qual- ity atomic resolution mapping and quantification of salient pro...
Closed-Loop Triaxial Optically Pumped Magnetometers for High-Sensitivity and High-Bandwidth Magnetoencephalography Measurements of the Developing Brain
PROJECT SUMMARY/ABSTRACT Non-invasive detection of gamma oscillations in infants will inform a broad range of studies examining neuro- developmental and neurodegenerative disorders...
The role of tetraspanin-regulated endolysosomal trafficking in Alzheimer's Disease
Although the accumulation of Aβ and subsequent chronic inflammation and neuronal dysfunction likely contribute to the development of Alzheimer’s disease (AD) pathology and clinical...
A pulse-labeling assay to track extracellular vesicle spreading in the brain
PROJECT SUMMARY Extracellular vesicles (EVs) are nano-sized secreted vesicles that carry biomolecules and mediate cell-cell communication. EVs are implicated in the development and...
WNT signaling in chondrocyte biology and osteoarthritis
Abstract Hip osteoarthritis (OA) affects one in four people by the age of 85, and it is linked to abnormal hip morphology including Cam-type femoroacetabular impingement (FAI). Hen...
Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel
Project Summary Nucleic acid aptamers (aptamers) have been used as therapeutic agents or delivery ligands for various biomedical applications such as regenerative medicine, cancer...
Optic Nerve Relays for Vision Restoration and Advancement Optic Nerve Regeneration Research
Project Summary/Abstract Optic neuropathies and retinal diseases are leading causes of irreversible blindness worldwide. Currently, there are no therapies to restore vision loss. W...
Role of Mitochondrial Metabolism in Regulating Species-Specific Developmental Rates
All mammalian embryos undergo a highly conserved sequence of developmental events, but different species complete this sequence at significantly different speeds.Astonishingly, emb...
DEVELOP GENOMEWIDE TECHNOLOGY TO PROFILE DNA ADP-RIBOSYLATION
PROJECT SUMMARY Our research program seeks to develop innovative technologies to investigate the role of ADP-ribosylation, an under-studied DNA modification implicated in critical...
Leveraging Sexual Dimorphism to Predict Cardiac Remodeling and Enhance Treatment in Women with Severe Aortic Stenosis
ABSTRACT Women with severe aortic stenosis (AS), a condition characterized by the narrowing of the aortic valve opening, often experience delayed diagnosis, undertreatment, and hig...
Elucidation of the upstream transcription factors controlling preeclampsia-specific gene expression using human trophoblast stem cells as a model system
PROJECT SUMMARY Preeclampsia (PE) is a relatively common pregnancy disorder that originates from the placenta. It affects up to 8% of all human pregnancies and causes various mater...
Development and Validation of Gaze-based Training for Endoscopic Kidney Stone Surgery
Project Summary The importance of achieving stone-free status during endoscopic kidney stone surgery is emphasized by the high rate of repeat stone procedures due to residual fragm...
A microphysiological model of the brain-lymphatic system in Alzheimer's disease
Summary The nervous system interacts with the immune system in ways that have been identified to contribute to a number of diseases, including Alzheimer’s disease, infection, brain...
Impact of Parental Bereavement on Social Connection, Isolation, and Health
PROJECT SUMMARY/ABSTRACT The pain of loss figures prominently for millions of Americans, and while the emotional toll of bereavement is well-recognized, resulting disruptions to so...
Drd3 transcript variants and cocaine self-administration
Project Summary This proposal is prepared in response to PAR-23-041, which supports projects that functionally validate and/or characterize genes or variants implicated in substanc...
Examining Influences of Place-Based Historical and Contemporary Structural Racism on Racial Disparities in Aging-Related Disease Risk Trajectories: Leveraging the HANDLS Dataset
Project Summary African Americans (AA) are at disproportionate risk for earlier and more pronounced cognitive and functional decline and increased frailty. Structural racism (SR)—t...
Inflammaging and Diabetic Retinopathy
PROJECT SUMMARY Diabetic retinopathy (DR) is a neurovascular complication of diabetes mellitus and the leading cause of blindness in adults. Prevention of hyperglycemia-induced ret...
Protein-Derived Cofactor in Bifunctional Enzyme KatG from Mycobacterium tuberculosis
Protein-derived cofactor in bifunctional enzyme KatG from Mycobacterium tuberculosis Project Description The catalase-peroxidase enzyme KatG is a heme-dependent protein critical fo...