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99,167 grants found
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Design and Validation of a Pelizaeus Merzbacher Disease (PMD) Severity Scale
Abstract: Pelizaeus Merzbacher Disease (PMD) is a rare X-linked hypomyelinating leukodystrophy caused by pathogenic variants in PLP, which encodes proteolipid protein 1 (PLP1) and...
Patient-Centered Outcomes in Carotid Artery Stenosis
Project Summary Abstract Older patients with carotid artery atherosclerotic disease are at risk of stroke, and some evidence suggests that people are affected by their carotid arte...
A novel oral immunotherapy for chronic visceral pain of irritable bowel syndrome
Abstract: Chronic visceral pain is a defining feature of irritable bowel syndrome (IBS) that is currently considered as a disorder of brain-gut interaction. Although pain is the mo...
Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome
Age-related cognitive changes: Effects of combined flavonoid intake and physical exertion mediated by the gut microbiome Age-related cognitive changes can be the first indication o...
ComPASS Health Equity Research Hub at UMB
ABSTRACT Despite decades of concerted efforts to eliminate health disparities experienced by minority racial and ethnic groups and other underserved populations, there remains a cr...
Epigenetics Biomarker of Post Operative Delirium and Long Term Cognitive Decline among Elderly Dementia Patients
PROJECT SUMMARY/ABSTRACT Delirium exposes patients to a greater risk of developing Alzheimer’s disease and dementia, and patients with Alzheimer’s disease and dementia are more lik...
Anesthesia Care Delivery in Rural America: The Impact of Organizational Climate on Burnout, Job Satisfaction, and Intention to Leave among Certified Registered Nurse Anesthetists
Burnout among Certified Registered Nurse Anesthetists (CRNAs) is a growing public health crisis with recent estimates as high as 72%. As CRNAs are the predominant anesthesia provid...
A novel murine model of 2-Hydroxyglutaric aciduria
Compound heterozygous missense mutations of the SLC25A1 gene give raise to combined D/L-2- HydroxyGlutaric Aciduria (D/L-2HGA) [1-10], a disease hallmarked by the accumulation of t...
Life-course acculturation trajectories and dementia in a multi-ethnic cohort of older adults: The MESA Acculturation and dementia Study
PROJECT SUMMARY/ABSTRACT There has been increasing emphasis on understanding the social-contextual factors that contribute to risk of Alzheimer’s Disease and related dementias (ADR...
Photoreceptor induction in wounded corneas
Project Summary/Abstract The cornea is the optically clear, curved tissue that provides the majority of refractive power in the eye. Improper healing of corneal wounds is a serious...
AI-guided miniproteins driving the production and functional endurance of pancreatic islet tissue from pluripotent stem cells.
Summary Stem cell (SC)-based replacement therapy is emerging as promising cure for diabetes. However, population-wide applicability of this approach remains constrained by the limi...
Cellular and developmental genetic regulation of 3' isoform diversity in the human brain and its contribution to neuropsychiatric disorders
PROJECT SUMMARY/ABSTRACT As large-scale genome-wide association studies (GWAS) continue to yield now thousands of genomic loci robustly associated with neurodevelopmental and psych...
Defining nuclear mechanisms for ultrarapid mechanically induced gene expression
Project Summary Cells in the human body are exposed to a broad range of mechanical forces. Cells respond to such mechanical stimuli with the expression of specific mechanoresponsiv...
Identification of proteins for breast cancer risk: an integrative epidemiologic and genomic study
Project Summary Genome-wide association studies (GWAS) have identified over 200 genetic loci for breast cancer. To translate these findings into an improved understanding of cancer...
Impact of lipids and food on oral compound absorption: mechanistic studies and modeling
Lipids in drug delivery systems and food can have a tremendous impact on the systemic absorption of orally delivered compounds, including drugs, nutrients, and toxins. However, thi...
Inner ear infection and innate immunity
ABSTRACT The inner ear is perfused by vessels that provide oxygen and nutrients to support the activity of hearing. This separation between the blood and inner ear fluids is mainta...
Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
ABSTRACT DNA double-strand breaks (DSB)s occur upon exposure of cells to ionizing radiation and chemicals in the environment, and when DNA replication forks become impeded by lesio...
Admin Core: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
ABSTRACT DNA double-strand breaks (DSB)s occur upon exposure of cells to ionizing radiation and chemicals in the environment, and when DNA replication forks become impeded by lesio...
Single-molecule nanopore-based identification of methylome signatures in cfDNA for early colorectal cancer detection
ABSTRACT The detection and characterization of cell-free DNA (cfDNA) is increasingly being used to detect cancer – this modality is frequently referred to as a liquid biopsy. Epige...
Project 3: Antagonistic Mechanisms of BRCA2 and the 53BP1 Axis in RAD51 Nucleoprotein Filament Assembly
Project Summary Homology-directed repair (HDR) is a major, high-fidelity pathway for the elimination of DNA double-strand breaks (DSB)s and for DNA replication fork maintenance. De...