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99,167 grants found
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Regulation of mitochondrial signaling by protein AMPylation
ABSTRACT Mitochondria are essential organelles that serve as the cellular hub for metabolism, ATP production, and redox signaling. We identified a novel mechanism of signaling in t...
Role of human-specific haplotype diversity on cell fate commitment
Project summary The primary focus of research in my laboratory centers on unraveling the causal relationship between common genetic variants in humans and susceptibility to complex...
Creating tools to make experimental biochemistry accessible to people with blindness
Project summary. People with blindness and low vision (BLV) experience systemic exclusion from biomedical science because the tools of experimental science—and the data they produc...
Probing protein structure and aggregation in complex environments with 2D IR spectroscopy
The goal of our proposed research program is to develop new spectroscopic methods capable of providing enhanced insight into protein structure and dynamics within complex environme...
Mutant KRAS targeted vaccines for the interception of pancreatic cancer development
ABSTRACT The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing, and despite the use of conventional therapies, including immune checkpoint inhibitors, 5–year survi...
The importance of failure in science education: Interventions to promote STEM motivation through failure
Project Summary/Abstract To meet national needs of the future, the United States must increase the production of biomedical college graduates and draw on a broader range of talent,...
Role of clonal somatic mutations in microglia and Alzheimer’s disease
Project Summary/Abstract Alzheimer’s disease (AD) and other neurodegenerative diseases are characterized by age-related onset and progressive neuronal loss. Neuroinflammation media...
Unraveling the molecular origins of chronic parenchymal lung diseases
PROJECT SUMMARY: Single-cell genomic studies have transformed our understanding of the cellular organization and plasticity of the human lung, providing substantial insights into m...
Metabolic therapy for atrial fibrillation
Atrial Fibrillation (AF) is the most common arrhythmia in the United States (US) with an estimated prevalence of 5 million and is expected to increase to 12 million by 2030. AF pos...
Disparities in undiagnosed and misdiagnosed dementia and the impact on health care utilization and costs - a novel approach using probabilistic dementia classifications
PROJECT SUMMARY/ABSTRACT Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) are the costliest diseases in the U.S. Yet they often go undiagnosed or get diagnos...
Mechanisms of spindle organization for cell division
During cell division, the precise positioning of the cell-cleavage plane at the center of a ~ 10-15 um long cell is essential for maintaining genome integrity. Consistently, cytoki...
The metabolic clock as a regulator of cell fate decision
Project Summary: Our organs respond dynamically to changes in the body’s demands by adapting both their size and activity levels. In these processes, mechanisms governing cell fate...
Molecular determinants of condensate assembly in heterogeneous environments
Project Summary Biomolecules, including proteins, nucleic acids, and metabolites, must first colocalize in order for biochemical reactions to take place. As a result, spatially org...
Advancing visible-light OCT in oxygen-induced retinopathy
PROJECT SUMMARY The oxygen-induced retinopathy (OIR) model has been a valuable preclinical model for understanding the pathophysiology of retinopathy of prematurity (ROP) and ische...
SMALL-MOLECULE AND NUCLEIC ACID ENGINEERING TOWARD MOLECULAR DESIGNS OF THERAPEUTIC POTENTIAL
PROJECT SUMMARY / ABSTRACT Designer small molecules and nucleic acid polymers are essential to the advancement of biotechnology and precision medicine. However, efforts to develop...
Efficacy of Teleconsultation to Improve Prehospital Patient Safety for Critically Ill Infants and Children - A Multicenter, Simulation-based Randomized Control Trial
ABSTRACT The Emergency Medical Services (EMS) 2050 Agenda for Future Systems envisions that telehealth tools could make prehospital care safer and more effective, but few EMS syste...
Financial stress, financial strain, asset depletion, and financial toxicity: New measures to characterize the financial impact that dementia has on families
ABSTRACT Financial hardship (including financial stress, financial strain, asset depletion, and financial toxicity) is a highly relevant construct among the 5.7 million people with...
REVAMP-PH: REpurposing Valsartan May Protect against Pulmonary Hypertension
Project Summary Although there has been substantial progress in the development of medications to lower pulmonary vascular resistance in pulmonary arterial hypertension (PAH), ther...
Dynamic retinal coding in natural environments
Project Summary Natural environments present numerous challenges to the visual system, including the presence of large and frequent changes in light intensity. Such changes occur w...
Mindfulness-based Neurofeedback to augment DBT psychotherapy for adults with Borderline Personality Disorder (MIND-BPD)
Project Summary The proposed project is a clinical trial of a mindfulness-based neurofeedback (mbNF) intervention used to augment Dialectical Behavior Therapy (DBT) skills group tr...