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99,167 grants found
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Durability of a gene editing therapy that restores dystrophin in a humanized mouse model of Duchenne muscular dystrophy
Project Summary Gene editing offers significant advantages for treating rare diseases since it edits the patient’s own DNA. Thus, the normal regulatory environment of the gene is m...
Randomized clinical trial of a telemedicine-mHealth symptom cluster intervention for advanced cancer patients: Increasing access in underserved rural communities
Abstract People with advanced cancer experience a greater frequency and severity of physical and psychological symptoms, ranking sleep difficulties, worry-anxiety, depression, and...
Developing multiparametric fluorescence microscopy to connect metabolism with cellular manipulations
Project Summary: Correlating metabolic changes with external or internal stimuli and cellular manipulations in high spatial detail is important for understanding causation and corr...
Flow Of Gene Expression Across Mitochondrial Condensates
Project Summary/Abstract: Phase transitions are emerging as a fundamental organizational principle for gene regulation. Transcription is organized into diverse higher-order structu...
Spatio-temporal cellular dynamics regulating differential healing outcomes
Project Summary / Abstract: Healthy individuals have a tremendous intrinsic ability to heal after injury. Wound repair involves complex and coordinated actions of various cell type...
Molecular Mechanisms of VMAT2 Function
Abstract Monoaminergic signaling controls many aspects of human physiology, including autonomic responses, movement, and emotion. The vesicular monoamine transporter 2 (VMAT2) is t...
Measuring What Matters-Patient Centered Outcome Measures of Goal-Directed Care for People with Serious Mental Illness
This proposal, submitted in response to NIMH RFA-MH-23-265, Developing Measures to Advance Quality in Mental Health Care Services, aims to develop Person-Centered Outcome measures...
A Validation Study of Satellite-based Measure of Artificial Light at Night for its Application in Epidemiological Research
PROJECT SUMMARY Artificial light at night (ALAN) is an emerging environmental. Growing research has linked higher ALAN exposures to a broad range of diseases, including cardiometab...
Randomized Trial of Corticosteroids for Post-Extubation Aspiration
PROJECT SUMMARY/ABSTRACT Dysphagia and aspiration are significant health problems associated with aging. By 2030, the United States elderly population is anticipated to exceed 72 m...
Discovery of novel disease modifying therapy for the prevention and treatment of glaucoma
R21 Grant Proposal Discovery of disease modifying therapy for the prevention and treatment of glaucoma Abbot F. Clark, PhD and David P. Siderovski, PhD Pharmacology & Neuroscie...
Multi-site, double-blind, randomized-controlled, efficacy trial of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for depression symptoms in older adults with high suicide risk
ABSTRACT: Older adults with moderate-to-severe depression symptoms (i.e., PHQ-9 scores ≥ 10) plus active suicidal ideation (SI) and/or a history of attempt are at high risk for sui...
Sample-to-answer HPV DNA nucleic acid test for cervical cancer screening in Mozambique
PROJECT SUMMARY / ABSTRACT Cervical cancer is the 4th most common female cancer and cause of cancer-related mortality worldwide, despite being preventable through HPV (human papill...
Utilizing spatially-informed cell-specific multicellular genome-scale metabolic models to unveil the mechanisms that regulate the decline of the ovarian reserve
PROJECT SUMMARY This proposal seeks to understand and predict the onset and duration of the menopause transition using a Systems Metabolic approach. Menopause, which is the complet...
Developing a novel human laboratory paradigm for AUD medication screening: Modeling the ability to resist drinking and heavy drinking
ABSTRACT Use of human laboratory analogues of drinking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on drinking, with the result...
Neural Mechanism of Impaired Satiation After Magel2 Mutation
Project summary Satiation is an important aspect of interoception that translates gut signals, such as cholecystokinin (CCK), into eating suppression. Insatiable appetite is associ...
A Blended e-Health Intervention for Fear of Progression in Advanced GYN Cancer
7.0 Project Summary/Abstract Up to 70% of patients with advanced cancer experience significant levels of FOP. FOP is the most common psychosocial concern among GYN and other cancer...
Mechanisms and Genetic Consequences of Break-Induced Replication.
PROJECT SUMMARY During normal cell metabolism, exogenous and endogenous factors cause double-strand DNA breaks (DSBs) that result in genome instability. DSB repair is critical for...
Inside Condensates: Bridging molecular structure and condensate material properties through simulation
PROJECT SUMMARY Proteins and nucleic acids within cells assemble into membraneless compartments referred to as biomolecular condensates. Condensates display a range of material pro...
Investigating the mechanisms of lysosome segregation and cell fate regulation in dividing hematopoietic stem cells
PROJECT SUMMARY Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases, but low HSC numbers and their tendency to differentiate in vitro are l...
A randomized comparative effectiveness trial of nicotine pouches for cigarette substitution: A question of public health
PROJECT SUMMARY Commercial cigarette smoking is a modifiable risk factor implicated in one-third of all cancer deaths. Nicotine is the chief addictive agent causing sustained smoki...