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99,167 grants found
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Expanding the capabilities of third-generation sequencing for multi-dimensional genome and transcriptome analysis.
Project Summary In cells, nucleic acids exist as molecular complexes, whose function depends not only on their base-pairing potential but also on their shapes and chemical structur...
Expanding CAR T cell applications through high-throughput forward- and reverse immune engineering
Adaptive immunity is one of the most complex and clinically relevant aspects of human biology, where immune cells have evolved over millions of years to discriminate non-self from...
Developing a CRISPR-free mammalian recombineering system
Developing a CRISPR-free mammalian recombineering system Project Summary / Abstract The ability to manipulate large segments of DNA in mammalian cells is essential for research and...
Enhancing Visual Accessibility of Indoor Spaces
Project Summary/Abstract The visual accessibility of a space refers to the effectiveness with which vision can be used to travel safely and pursue intended activities in the space....
Vertically Integrated Approach to Design a Biologically and Mechanically Optimized Vascular Conduit for Dialysis Vascular Access
ABSTRACT Dialysis vascular access (arteriovenous fistulae [AVF] and arteriovenous grafts [AVG]) is the Lifeline for the 500,000+ patients on hemodialysis in the United States (3mil...
A hybrid effectiveness-implementation trial to integrate precision skin cancer risk feedback in federally qualified health centers
ABSTRACT The incidence of skin cancer has increased over the past several decades. Limiting exposure to ultraviolet radiation and engaging in early detection can reduce skin cancer...
Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking: A Randomized Controlled Trial
PROJECT SUMMARY Tobacco use remains the leading preventable cause of death and illness in our society and causes 30% of cancer deaths. Despite this, 28.3 million US adults smoke. M...
High-dimensional chemical targeting of multiple neuron types to regulate energy balance
Summary Recent drugs for treating obesity and diabetes, while promising, have major side effects. For example, drugs that reduce food intake by targeting the melanocortin-4 recepto...
Implementing depression and adherence treatment in S. Africa HIV care
PROJECT SUMMARY Background: Evidence-based treatments for depression and treatment adherence in persons with HIV (PWH) are not reaching a sufficient number of PWH who need them, an...
Personalized genomics signal deconvolution to improve cell-type level inference
Abstract: The real-world clinical bulk sequencing samples contain mosaics of various cell types. The recent success of signal deconvolution methods demonstrated that properly accou...
Understanding the role of Hdacs in zebrafish craniofacial development
One third of all birth defects are associated with craniofacial malformation including lack of suture closure, cleft palate, or failure of skeletal formation. Progress in understan...
A Systems Approach for Elucidating Genetic Determinants of Human Brown Adipose Tissue Function
Obesity directly contributes to comorbid diseases which account for the leading causes of morbidity and mortality in much of the world.Although functional brown adipose tissue (BAT...
Expanding the design space of polyelectrolyte complex micelles
PROJECT SUMMARY Polyelectrolyte complex micelles (PCMs) are a unique class of self-assembled nanoparticles that form with a core of associated polycations and polyanions surrounded...
Discovery of Chemical Factors in the Gut Microbiome that Control Alpha-Synuclein Aggregation in Parkinson's Disease
PROJECT SUMMARY. Accumulation of α-synuclein (α-syn) protein aggregates in brain neurons is thought to play a causal role in Parkinson's disease (PD). There is mounting eviden...
Low Energy Availability (LEA), Nutritional Deficiencies and Hypertension in Black Division I Athletes
Title: Low Energy Availability (LEA), Nutrient Deficiencies, and Hypertension in Black Division I Athletes SPECIFIC AIMS: The International Olympic Committee on Sports Nutrition (I...
Neural circuit mechanisms for a mirror-induced self-directed behavior
PROJECT SUMMARY The ability to remember one's own features and monitor the current states is a fundamental for self- recognition. To experimentally demonstrate the visual self...
Causes and consequences of genomic instability in myelodysplasia
PROJECT SUMMARY/ABSTRACT Myelodysplastic syndromes (MDS) are a group of age-related marrow failure disorders characterized by cytopenia and anemia. It is estimated that 10,000 new...
Nanoparticles to reprogram innate immune cells and disrupt the metastatic niche
Summary. Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that is treated with neo-adjuvant therapy that targets both the primary tumor and systemic dise...
Molecular mechanisms of developmental reprogramming in colorectal cancer
Colorectal cancer (CRC) is growing global threat, especially among younger adults. Impaired differentiation is a critical mechanism by which CRC cells unlock cell state plasticity;...
Estimating Impacts of Social Safety Net Generosity on Neglect and Physical Abuse in Young Children
Summary Approximately 1 in 3 children in the US experience neglect and/or abuse (“maltreatment”) before they turn 18-years old, with marginalized racial and ethnic communities and...