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99,167 grants found
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Analytic diagnosis methods for disease ruling
PROJECT SUMMARY/ABSTRACT Disease ruling, that is, ruling-out or ruling-in, is a main objective of cancer diagnosis to aid in medical decision making. Taking prostate cancer as our...
Intrathecal baclofen and pediatric dystonia.
Over 11,000 infants are diagnosed annually with cerebral palsy (CP) with lifetime medical costs >$1.4 million/person. Elevated muscle tone includes dystonia (involuntary muscula...
Nonviral Delivery of CRISPR-Cas9 into Hepatocytes Combined with APAP Selection for Treatment of Familial Hypercholesterolemia
PROJECT SUMMARY Familial hypercholesterolemia (FH) affects 1 in 250 people and is characterized by impaired low-density lipoprotein (LDL) metabolism resulting in premature cardiova...
Mechanisms underlying aged host-virus interactions
PROJECT SUMMARY The elderly proportion of the human population is increasing rapidly on a global scale leading to unprecedented demographic shift impacting families, governments an...
Prediction and Significance of Cancer in Idiopathic Inflammatory Myositis
PROJECT SUMMARY Idiopathic inflammatory myopathies (IIM) comprise a heterogeneous group of chronic autoimmune diseases that can lead to severe muscle weakness and chronic disabilit...
Genetic and genomic effects of increased transposition
PROJECT SUMMARY Aging can be defined as the progressive gradual decline in physiological function. It is the major risk factor for human pathologies that lead to disease, morbidity...
Examining Complex Transactional Associations among Family Media Use, Caregiver-Child Interactions, and Behavioral Functioning in At-Risk Young Children
Project Summary Digital technology and screen media have become increasingly ubiquitous in the lives of young children, fueling urgent calls for better understanding how screen med...
Using an in vivo multi-lifetime model to test mechanisms of aging
Project Summary Species exhibit stereotypic lifespans, suggesting an intrinsic hardwired limit. Our preliminary data shows that a population of mouse T cells can be iteratively boo...
Developmental transcription factors in Drosha-driven cancer
PROJECT SUMMARY/ABSTRACT Pineoblastoma is one of a family of childhood cancers that can arise through mutations in microRNA processing genes DROSHA and DICER1. It is unknown whethe...
Genetic modulation of inflammation following myocardial infarction
PROJECT SUMMARY Following a myocardial infarction, an intense inflammatory response occurs whose duration and magnitude are modulated by CD4+CD25+Foxp3+ regulatory T cells (Tregs)...
Systematic Brain-Body Communication and Personalized Aging Trajectories
Project summary (16 lines): The brain constantly communicates with the rest of the body through a complex network of nerves, hormones, and immune cells. Brain-body communication is...
Novel Strategies to Enhance Drug Delivery and Tumor Immunogenicity in Pancreatic Cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer with limited treatment options and a low overall survival rate. Oncolytic viruses, particular...
Development of Two Novel AMD Models for Evaluation of RPE Protection by the Novel Antioxidant D-DHA
PROJECT SUMMARY Geographic atrophy (GA) is the advanced form of dry age-related macular degeneration. Recently, anti-complement drugs have shown moderate efficacy in slowing diseas...
Novel extremophile-inspired radioprotectants
Project Summary Over 60% of cancer patients undergo radiation therapy during their disease process, which frequently leads to injury to surrounding healthy tissue and results in co...
Identifying Mitochondrial Mechanisms Driving Learning and Memory
Project Summary The overall goal is to understand the energy supply mechanisms of learning and memory. The human brain is a metabolically vulnerable organ, where even an acute inte...
Tracing the evolutionary history of human adaptive traits through ancient DNA
PROJECT SUMMARY As modern human expanded worldwide, they settled in different environments that subjected them to selective pressure, driving genetic adaptations to varied local co...
Exploration of DNA functionality using language models
Project Summary Deoxyribonucleic acid (DNA), carrying genetic instructions for the growth, functioning, and reproduction of most living organism, presents a critical avenue for exp...
Enhancing CAR T cell fitness using novel epigenetic reprogramming factors
PROJECT SUMMARY/ABSTRACT Chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable clinical responses in patients with B cell malignancies. However, approximately...
Direct chemical targeting of MHC proteins for the treatment of cancer and autoimmune diseases
Project Summary/Abstract Recognition of peptide antigens presented by major histocompatibility complexes (MHCs) by T cell receptors is a fundamental molecular mechanism by which T...
Programmable depletion and rescue platform to screen dynamic regulatory events during cellular differentiation.
PROJECT SUMMARY: The mechanisms by which stem cells orchestrate their program to become functional differentiated cells require accurate temporal regulation of specific gene expres...