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99,167 grants found
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Impact of Medicare and Medicaid Financial Policies on Post-acute and Long-term Care for Persons Living with Dementia
Project Summary: The current proposal, developed in response to RFA-AG-24-031 (Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care) will leverage the last 1...
Investigating epigenetic mechanisms of cancer
Project Summary Disruptions of epigenetic mechanisms that regulate gene expression are frequently found in cancer and collaborate with genetic alterations to drive cancer phenotype...
Predicting Post-Covid Pulmonary Fibrosis with Explainable Deep Learning and Optimal Biomarker Discovery
PROJECT SUMMARY Since the beginning of COVID-19 (SARS-CoV-2) pandemic, we have seen a number of prominent variants, and two of them are very recent. COVID-19 continues to affect mi...
The next generation of liquid biopsies: Predictive and pharmacologic biomarkers
Project Summary: The laboratory of Dr. Joshua Lang is focused on targeting treatment resistant PCa through developing new biomarkers for precision medical strategies using liquid b...
Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to Therapy
ABSTRACT Fetal reversion is a novel regenerative phenomenon in which cells of the intestinal epithelium respond to damage by downregulating the normal gene expression program obser...
Development and Deployment of Liquid Biopsies in Bench Research and Clinical Trials in the UW Circulating Biomarker Core
Minimally invasive liquid biopsies have revolutionized our understanding of cancer biology and emerged as biomarkers for disease monitoring and drug development, but have been limi...
Exosome Secretion in Tumor Aggressiveness
PROJECT SUMMARY Exosomes are a type of small extracellular vesicle (EV) secreted from all kinds of cells, derived from endosomes. They have many physiological and pathological func...
Roles of circHIPK3 and HuR in aging gut barrier function
Abstract Despite the on-going debate as to whether there are changes in gut barrier function during healthy aging, clinical studies consistently support an increased risk of infect...
Alcohol Use Disorder: Acamprosate Pharmacometabolomics-informed Pharmacogenomics
PROJECT SUMMARY/ABSTRACT Acamprosate and naltrexone are major medications used in the treatment of alcohol use disorder (AUD). However, response to treatment with these drugs is va...
The role of language acculturation in the hearing loss-cognition association among Hispanics in the US
Project Summary Our project focuses on the high prevalence of Alzheimer's disease and related dementias (ADRD) among the Hispanic population in the United States. In 2014 ADRD...
Development and function of corneal lens-secreting cells
The human cornea is a precisely curved transparent structure composed primarily of extracellular matrix (ECM) that is able to refract light and focus it on the retina. Genetic defe...
[R01] Prioritizing food systems interventions to reduce adolescents’ nutrition insecurity and malnutrition in low-income settings
ABSTRACT Nearly one third of the world’s population lacks access to adequate food, and over three billion people cannotafford a healthy diet. Nutrition insecurity - the lack of con...
Neuronal activity-responsive DNA repair mechanisms and cognitive aging
Project Summary: Accumulating genomic damage to neurons is a cardinal feature of Alzheimer’s disease and the normal aging process. Although cognitive stimulation has been shown to...
Localized small molecule delivery to improve tendon-to-bone integration following anterior cruciate ligament reconstruction
Anterior cruciate ligament (ACL) injuries are one of the leading causes of training and sports related injuries and contribute to post-traumatic osteoarthritis. Torn ACLs are commo...
Neural mechanisms of flexible visual-oculomotor decision rules
PROJECT SUMMARY Visual decision-making in the brain is thought to depend on two behaviorally distinguishable computational components: one that converts uncertain visual inputs int...
Neural Signature Changes Across Early Abstinence in Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Alcohol use accounts for 1 in 5 deaths of individuals aged 20 to 49-years old, and Alcohol Use Disorder (AUD) is associated with deficits in brain structur...
Simultaneous Downfield and Upfield proton MRSI at 3T
PROJECT SUMMARY In the past, nearly all clinical and research proton magnetic resonance spectroscopy (MRS) studies of human brain metabolism have focused on the resonances upfield...
The Financial Impact of Burnout and Mental Health on Hospitalist Turnover and the Contribution of Work Structures and Environment
PROJECT SUMMARY/ABSTRACT Hospitals across the United States are increasingly relying on physicians and advanced practice providers who care for hospitalized patients (hospitalists)...
Robotic OCT for automated mapping of outer retinal layer thicknesses
PROJECT SUMMARY This Exploratory/Developmental Research Grant proposal seeks to advance the state of the art in diagnostic ophthalmic imaging with a novel, robotically-aligned opti...
Targeting GARP-TGFbeta for Immunotherapy of Non-Small Cell Lung Cancer
PROJECT SUMMARY Although immune checkpoint blockade (ICB) has become a standard cancer therapy, most patients – including ~70% of those with non-small cell lung cancer (NSCLC) – fa...