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Mitochondria mediated intercellular metabolic coupling in bone marrow regeneration
(PLEASE KEEP IN WORD, DO NOT PDF)Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Hematopoietic s...
Modulation of CD8+ T cell differentiation and anti-tumor immunity by metabolic manipulation
PROJECT SUMMARY / ABSTRACT CD8+ T cells are critical determinants of the anti-tumor immune response. The TCF1+ progenitor-exhausted subset of CD8+ T cells is critical to their ther...
Activation of SLFN12 RNase Activity by Dimerization
Velcrin compounds kill cancer cells expressing elevated levels of PDE3A and SLFN12 by inducing complex formation between these two proteins. Velcrin-induced PDE3A-SLFN12 complexes...
Testing development, acceptability, feasibility and costing of MARBAR-Africa (a routine outcome interactive measurement dashboard) for improved psychotherapy outcomes in specialist public health care
Project Summary This is a pathfinder project that will begin by developing a prototype of a dashboard for routine outcomes monitoring in psychotherapy and mental health clinics in...
Endothelial RASOpathies and Vascular Malformations
SUMMARY RAS signaling has been implicated in a wide spectrum of processes central to normal development and disease. Human mutations in RASA1 (a GAP negative regulator of RAS) are...
A culturally tailored anti-inflammatory diet for Hispanic patients with ulcerative colitis
PROJECT SUMMARY Ulcerative colitis (UC) is on the rise globally, including among Hispanic/Latinos (H/L). Despite growing evidence of the importance of diet in UC, few clinical tria...
Evaluating accessory cells to improve homing and engraftment efficiency of CD34+ cells from sickle cell disease patients
As a cure for the life-threatening hemoglobinopathy of sickle cell disease (SCD), gene therapy has immense potential, avoiding the burdens with allogeneic transplant of finding an...
Water Contaminants and Cardiovascular Risk: the Jackson Heart Study
PROJECT SUMMARY/ABSTRACT In Jackson, MS, decades of under-investment in public water system infrastructure have resulted in severe disruptions to water access and diminished water...
The Role of Phosphoinositides in Influenza Virus Assembly
Influenza virus causes significant illness and mortality in the U.S. and worldwide. Vaccines offer some protection, but must be continuously tailored to mutations of the virus. Som...
Possible transfusion transmitted cerebral amyloid angiopathy: evaluation of transmission of Aβ using the RADAR repository
PROJECT SUMMARY/ABSTRACT Cerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage (ICH), with a case fatality rate of 30-50%. CAA is characterize...
The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)
PROJECT SUMMARY Pituitary neuroendocrine tumors (PitNETs) are rare and understudied heterogeneous tumors that are detrimental to health causing increased mortality and poor quality...
South African Manganese EnvironmentaL NeuroToxic Effects Research (SMELTER)
Abstract Manganese (Mn) is a well-established neurotoxicant that likely induces neurodegeneration through inflammatory pathways. Millions of people worldwide experience high levels...
Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass
The methods used to measure NAD+ and NADH in human samples include the enzymatic cycling assay, high pressure liquid chromatography and liquid chromatography tandem mass spectromet...
Towards a molecular biology of human olfaction in health and disease
Project Summary/Abstract The olfactory epithelium is the peripheral organ for smell, housing millions of primary olfactory sensory neurons. Insults such as inflammation, infection,...
Characterizing brain-periphery cortisol dysregulation in AUD
PROJECT SUMMARY/ABSTRACT Alcohol directly stimulates the hypothalamic-pituitary-adrenal (HPA) axis, a primary stress system, initiating the release of glucocorticoid hormones. Prec...
Director Genomics Shared Resource
PROJECT SUMMARY / ABSTRACT The current application seeks salary support for Prashant K. Singh, PhD who serves as the Director of the Genomics Shared Resource (GSR) at Roswell Park...
Artificial Intelligence for effective communication to promote vaping cessation on social media
PROJECT SUMMARY The National Youth Tobacco Survey showed the prevalence of e-cigarette use among high school students has skyrocketed from 12% in 2017 to 28% in 2019 and remains hi...
Mitochondrial nutrient transport and trophoblast differentiation
PROJECT SUMMARY Diabetes and obesity in pregnancy cause abnormalities in placental development that underlie adverse pregnancy outcomes such as spontaneous abortion, preeclampsia,...
Development of Protein Degraders Targeting EZH2 Non-enzymatic Functions in Prostate Cancer
Summary Prostate cancer (PCa) is the most commonly diagnosed non-skin cancer in American men. A majority of localized PCa can be effectively managed by radiation and surgery, with...
Impact of Environmental Stressors on Ischemic Stroke Outcome Inequities in Alzheimers Disease and Related Dementias
Persons with Alzheimer’s disease (AD) and AD-related dementia (AD/ADRD) are vulnerable to heat-illness, particularly in socioeconomically disadvantaged neighborhoods, due to limite...