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A meta-transcriptomic assessment of chronic respiratory exposure to cobalt-based nanomaterials using a microfluidic three-dimensional lung model for determining potential predisposition to lung injury
Project summary The use of cobalt-based nanomaterials has increased recently since they have many of the same attractive properties as other metallic nanoparticles, but appear to b...
Opioid Use Disorder Pharmaceutical Treatments: Investigating a Model and Measure of Intervention Stigma toward Medication (OPTIMISM)
Project Summary/Abstract Medication for Opioid Use Disorder (MOUD) is an effective but underused treatment for Opioid Use Disorder (OUD), reducing drug use and mortality at rates f...
Promoting Inclusive Excellence
Enter the text here that is the new abstract information for your application.Systemic inequities, defined as the ‘structures, policies, practices, and norms that assign value and...
Effective Ultrasound Neuromodulation in the Awake Primate Brain
Ultrasound neuromodulation promises to revolutionize treatment for neurological and mental disorders by providing pre-cise, non-invasive treatment of the neural circuits involved i...
Novel correlations in cellular, molecular and structural alterations in experimental juvenile myopia
Summary Myopia is a complex and multigenic refractive disorder that does not only impair vision but also increases the risk factor to develop irreversible blinding diseases later i...
Cellular, neurogenomic and neuroendocrine mechanisms underlying variation in social behavior
Project Summary The social environment has profound effects on organismal biology, including human health. Individuals vary in their physiological and behavioral responses to socia...
Identifying favorable regions of the conformational landscapes of peptides and peptidomimetics
PROJECT SUMMARY Therapeutic Potential of Macromolecules: The human interactome, potentially comprising over 650,000 protein-protein interactions (PPIs), remains an underexplored fr...
Harnessing the Power of Kmers: Concepts and Methods for Genomic and Proteomic Research
PROJECT SUMMARY / ABSTRACT In the modern era of genomics and proteomics, the vast amounts of biological data generated present both a challenge and an opportunity. Central to this...
Testing energy expenditures as biomarkers of aging using thermal imaging in a controlled environment
Project Abstract Rodent animal models are key to understanding the fundamental biological mechanism and to advancing clinically relevant testing, including aging and age-related di...
Understanding and Communicating Reproductive Health Consequences for Male Wildland Firefighters
Project Summary/Abstract Wildfire activity is increasing resulting in greater numbers of firefighters conducting suppression and prescribed fire activities each year to protect liv...
Experimentally-validated model of glymphatic disruption due to spreading depolarization
Project Summary/Abstract Spreading depolarization (SD) occurs following many acute neurological conditions and is characterized by the loss of ion gradients across neuronal and ast...
ESTABLISHING THE NEUROPHYSIOLOGICAL BASIS FOR RESTORATION OF NATURAL BLINK
PROJECT SUMMARY Facial paralysis from stroke or other neurological disorders often causes loss of the eye-blink reflex, leading to pain and visual disability. Eyelid dysfunction le...
The Impact of Hospice Care on the Wellbeing of Alzheimer's Disease Patients and Their Family Members
OTHER PROJECT INFORMATION – Project Summary/Abstract The Impact of Hospice Care on the Wellbeing of Alzheimer's Disease Patients and Their Family Members Given the increasing...
Elucidating Cerebellar Contributions to Social Cognition: A Transdiagnostic Investigation
PROJECT SUMMARY Many individuals living with serious psychiatric disorders – including those that span the psychosis, autism, and anxiety spectrums – experience significant social...
Chromosome Packing Inhibitors for the Treatment of Eye Infections
Chromosome Packing Inhibitors for the Treatment of Eye Infections ABSTRACT Bacterial eye infections frequently arise as a complication of corrective surgery or contact lens use. Th...
Strengthening the Dementia Care Workforce: Analyzing Economic Policies' influence on Workers and their Patients Living with Dementia
Project Summary The long-term care industry is one of the fastest growing sectors of the economy1, while also creating some of the lowest-paid and lowest-quality jobs. These precar...
Chromatin Dynamics During Epithelial Commitment
Project Summary/Abstract To treat wounds that won’t heal for patients with Recessive Dystrophic Epidermolysis Bullosa, we have developed induced pluripotent cell (iPS)-cell derived...
Cross-Disease Multi-Modality Mapping of the Human Lung
PROJECT SUMMARY The tremendous diversity across human lung diseases presents significant clinical challenges, but also offers remarkable opportunities for capturing high-resolution...
Promoting gynecologic cancer patients with frailty to achieve functional recovery cohort study (PROOF Cohort Study)
Project summary and abstract Approximately 80% of patients with ovarian cancer and 30% of patients with uterine cancer are diagnosed with advanced disease. In the absence of effect...
Mechanisms of chemosensory neuron cilia regeneration
PROJECT SUMMARY Primary non-motile cilia protrude from the cell surface of the majority of metazoan cells and act as cellular ‘antennae’ to sense and transduce environmental inform...