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99,167 grants found
Showing 161 – 180 of 99,167 grants
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer’s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-p...
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer?s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-pre...
From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects
PROJECT SUMMARY Spinal cord stimulators (SCS) and related devices are commonly used to treat refractory pain conditions, although mechanisms underlying pain reduction remain uncl...
North American Prodromal Synucleinopathy Consortium for RBD, Stage 2 (NAPS2)
Most individuals with rapid eye movement (REM) sleep behavior disorder (RBD) develop additional neurological symptoms and are subsequently diagnosed with overt synucleinopathies, i...
Additional Sequencing for the Alzheimer Disease Sequencing Project (ADSP) the Follow-Up Study (FUS), The Diverse Population Initiative
ABSTRACT The Alzheimer’s Disease Sequencing Project (ADSP) is a national sequencing initiative focused on identifying genetic risk factors for AD. The project’s discovery phase i...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population....
North American Prodromal Synucleinopathy Consortium for RBD, Stage 2 (NAPS2)
Most individuals with rapid eye movement (REM) sleep behavior disorder (RBD) develop additional neurological symptoms and are subsequently diagnosed with overt synucleinopathies, i...
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer’s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-p...
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
Abstract/Summary Progress in understanding Alzheimer’s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-p...
Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF Trial
Acute decompensated heart failure (ADHF) is the leading cause of hospitalization in older persons, and is associated with marked physical disability, poor health-related quality o...
CoVPN 3008 A Phase 3, Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern
Abstract: With the global COVID-19 pandemic, we recognize a significant need for vaccines that modify COVID-19 in SARS-CoV-2 infected individuals. Addressing this gap, the National...
Human cortical development and neural plasticity altered by trisomy 21
ABSTRACT Down syndrome (DS, trisomy 21, T21), a complex multigene disorder and the most common genetic cause of intellectual disability. However, surprisingly little is known about...
PanCorVac (Center for Pan-Coronavirus Vaccine Development)
SUMMARY Most of the vaccines currently approved or in development against the pandemic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus target immunodominant, st...
Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke Trial
The Multi-arm Optimization of Stroke Thrombolysis (MOST) stroke trial will be a double-blinded multi-center, randomized controlled Phase 3 trial with a maximum of 1200 subjects. Th...
Generation, Characterization, and Validation of Marmoset Models of Alzheimer's Disease
PROJECT SUMMARY OVERALL Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting nearly 6 million Americans and is expected to increase over the next sever...
Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center
PROJECT SUMMARY/ABSTRACT The overall goals of our Childhood Asthma in Urban Settings (CAUSE)-Leadership Center proposal are to provide administrative leadership and support to deve...
Additional Sequencing for the Alzheimer Disease Sequencing Project (ADSP) the Follow-Up Study (FUS), The Diverse Population Initiative
ABSTRACT The Alzheimer’s Disease Sequencing Project (ADSP) is a national sequencing initiative focused on identifying genetic risk factors for AD. The project’s discovery phase i...
COVID Protection After Transplant (CPAT) Multicenter Adaptive Trial
Solid organ transplant recipients experience high mortality from COVID-19 due to a combination of immunosuppression and comorbidities. Although SARS-CoV-2 vaccination has been high...
Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF Trial
Acute decompensated heart failure (ADHF) is the leading cause of hospitalization in older persons, and is associated with marked physical disability, poor health-related quality o...
Penn-CHOP ECHO
Project Summary Health disparities start early in life, with Black infants (10.6 per 1,000) twice as likely to die compared to White infants (4.5 per 1,000). Adverse pregnancy ou...