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99,167 grants found
Showing 1,741 – 1,760 of 99,167 grants
Identifying mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis
Program Summary Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by loss of motor neurons that leads to weakness, respiratory failure,...
The Role of Oculomotor Proprioception in the Establishment of Long-Term Visuospatial Memory
Abstract You can point the door of the room with your eyes closed. Patients with certain brain lesions cannot, although they can point to it if they can see it. Establishing a spat...
Biobank phenotyping tools for improved understanding and management of eye diseases and disparities
PROJECT SUMMARY One of the areas of emphasis on the National Eye Institute's (NEI) strategic plan is to bridge the gap between genomics and mechanisms of disease. Vast clinica...
Leveraging community-to-facility service provision to implement the World Health Organization HEARTS-D guidelines in Bangladesh for improving diabetes control and prevention.
PROJECT SUMMARY Type-2 diabetes (T2D) is rising at an alarming rate in most of low- and middle-income countries (LMIC). This rapid increase in the T2D burden has a particular impac...
Protein sequence influence on single-molecule transport dynamics
ATP-Binding Cassette (ABC) Transporters are paradigmatic molecular machines that use ATP binding and hydrolysis to power transmembrane transport of diverse substrates. Knowledge of...
Impact of Ethnicity on the Utility of Plasma Amyloid and Tau to Predict Alzheimer's Disease
ABSTRACT The development of biomarkers for Alzheimer’s disease resulted in the use of positron emission tomography (PET) and biofluid assays to detect AD pathology before clinical...
Basal Forebrain Non-cholinergic Circuit Mechanisms of Sustained Attention
ABSTRACT The long-term goal is to understand how basal forebrain (BF) circuits underlie cognitive functions like sustained attention. Traditionally, BF was thought to mediate atten...
Assessing the efficacy of a ROR1:PD-L1:CD2 multispecific T cell engager in ROR1-positive and -negative neuroblastoma models
PROJECT SUMMARY/ABSTRACT Few children with recurrent neuroblastoma survive. New therapies, particularly immunotherapies, are badly needed. Some promising results have recently been...
Adapting and testing a smoking cessation intervention for transgender and gender-diverse individuals
Despite the substantial decrease in the prevalence of smoking over the past 50-years, there are persistent and significant disparities in tobacco use among transgender and gender d...
1/2 Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension
Project Summary/Abstract Despite advances in medical therapy for pulmonary arterial hypertension (PAH), mortality rates are still unacceptably high. This may be partly due to the l...
ApolipoproteinL1 Genotypes and Biomarkers of Immune Activation and Tubular Injury
PROJECT SUMMARY Chronic Kidney Disease (CKD) can effectively be a death sentence in sub-Saharan Africa where
Leveraging 30 years of Alzheimer's disease clinical trials data to decipher phenotypic response to treatment
PROJECT SUMMARY Looking back to move forward: The overall goal of this proposal is to examine the role of specific phenotypes, or subgroups of people based on a given characteristi...
Expanding Inclusion of All Subjects for Ultra-High Density Wearable fNIRS in the Everyday World
Abstract There is a great need to enable scientists to link brain activity to human movement, perception and cognition, and social communication and interaction continuously, in re...
Decoding the Brain-Liver Axis: Uncovering mechanisms of host defense
This research proposal seeks to uncover neuronal mechanisms orchestrating metabolic adaptations to bacterial infections, specifically delineating the pivotal role of the brain-live...
Community Mitigation Against Xylazine
PROJECT SUMMARY/ABSTRACT We propose to use the Behavioral Model for Vulnerable Populations as a framework to examine the feasibility and acceptability of a community-based drug che...
Expanding CMV peptide vaccine with novel combinations and pathologies
Project Abstract Pediatric high-grade glioma (pHGG), diffuse midline glioma (DMG), recurrent medulloblastoma (MB), and recurrent ependymoma are devastating diseases. The median ove...
Non-genotoxic HSCT for ATM
Project Summary Ataxia telangiectasia (A-T) is a genetic disorder resulting from mutations in the ATM protein, essential for DNA repair and maintaining genomic integrity. Patients...
Characterizing autonomic impairments in Frontotemporal Dementia
PROJECT SUMMARY/ABSTRACT Socioemotional impairments are core features of behavioral variant of Frontotemporal Dementia (bvFTD) and account for the majority of disease related morbi...
Abandoned Settlements, Abandoned Health
Project Summary Up to 3 billion people will reside outside of the human climate niche due to climate change by the end of the century and the wholesale abandonment of communities a...
Resolution of nonalcoholic fatty liver and nonalcoholic steatohepatitis by a novel adipokine
Project Summary Nonalcoholic steatohepatitis (NASH) is initiated by lipid accumulation in hepatocytes and further characterized by lobular inflammation, hepatocyte ballooning, and...