Browse All Grants
99,167 grants found
Showing 1,701 – 1,720 of 99,167 grants
Mechanistic modeling to link scRNAseq data to physiological predictions
PROJECT SUMMARY The overall goal of this R21 application is to develop methods to predict how the presence of multiple subtypes of ventricular cardiomyocytes influences cardiac fun...
Reducing obesity through play: A randomized control trial
1 ABSTRACT 2 Obesity and related chronic diseases that result from years of poor diet and physical activity (PA) may be 3 prevented by wellness programs for toddlers (18–36 months)...
Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis
PROJECT SUMMARY Mitral valve prolapse (MVP), a condition affecting 2-3% of the general populace, is typified by irregular thickening of valve leaflets. The histopathological modifi...
Characterization of colonization and protein secretion by Pichia pastoris in the gastrointestinal tract of mice
PROJECT SUMMARY Rising expense associated with stability and delivery are significant obstacles for using therapeutic proteins to treat diseases. To resolve these issues, we propos...
Deciphering Transcription Factor-Coregulator Interactions through Innovative Tools
ABSTRACT Transcription factors and their coregulators are pivotal in directing gene regulation, cellular differentiation, and disease progression. Acting as molecular switches, the...
Time-Resolved and Multi-Temperature Structural Biology to Understand Dynamic Enzyme Catalysis
Project Summary Enzymes, proteins which perform chemical reactions, are required for all of life. These proteins are amazing and specific catalysts that are tightly regulated to en...
A novel physical activity metric predicts cognitive and brain aging and ADRD risk
Project Summary Low physical activity (PA) levels have been associated with elevated risk of Alzheimer’s dementia and related disorders (ADRD). The bulk of this evidence has been d...
Tradeoffs Between the Equal and Equitable Distribution of a Scarce Health Resource: Evidence from a Large Randomized Natural Experiment with Targeting by Health, Social Vulnerability, and Race
Tradeoffs Between the Equal and Equitable Distribution of a Scarce Health Resource: Evidence from a Large Randomized Natural Experiment with Targeting by Health, Social Vulnerabili...
Neural Activity Signatures of Tumor Infiltration in the Human Brain
ABSTRACT In brain cancer, tumor cells form complex interactions with cells in the brain. Recent studies have revealed a complex interaction between brain cells, or neurons, and tum...
Apolipoprotein E genotype modulates brain mitovesicle production, a component of mitochondrial quality control
ABSTRACT : Generation of extracellular vesicles and their release from a cell contributes to cellular waste removal, mediates the transport of materials between cells, and propagat...
Urothelial Cells and Sensory Signaling
PROJECT SUMMARY Urothelial cells play an active role in bladder physiology by responding to physical/chemical stimuli and signaling to sensory neurons and other cell types in the b...
ER calcium handling, single cell processing, and neural circuit function in vivo
Summary Calcium is a critical second messenger in neurons, regulating neuronal processes from dendritic integration to synaptic transmission. The endoplasmic reticulum (ER) is the...
Neurodevelopmental mechanisms in 17q12 CNV disorders and autism
PROJECT SUMMARY Copy number variants (CNVs) are contiguous gene deletions or duplications that confer susceptibility to neuro- psychiatric and neurodevelopmental disorders (NDDs)....
Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation
PROJECT ABSTRACT Cancer-related fatigue (CRF) is one of the most common and functionally limiting symptoms reported by cancer survivors. While no standard of care exists for CRF ma...
Molecular determinants of cytotoxicity due to mutant myocilin misfolding
Glaucoma is a heterogeneous ocular disease that affects nearly 70 million individuals worldwide. Despite the availability of symptomatic treatments and surgeries, ~10% of patients...
Development of a MT-stabilizing agent for the treatment of tauopathies
PROJECT SUMMARY A group of neurodegenerative diseases referred to as tauopathies, which includes Alzheimer’s disease (AD), are characterized by the presence within brain neurons of...
PRC2 independent role of Ezh2 in regulation of basal cell dynamics post-influenza virus infection
Project Summary: Influenza is a major global health threat causing over half a million deaths each year. Certain virulent strains, such as H1N1, can cause extensive lung damage, le...
Role of Matrix Stiffness and Genetic Risk Factors in AMD-Associated Epithelial-to-Mesenchymal Transition
PROJECT SUMMARY Several lifestyle and genetic major risk factors for age-related macular degeneration (AMD) are generally associated with increases in extracellular matrix (ECM) st...
Unlocking Corneal Endothelial Regeneration: Novel Therapeutic Strategies for Fuchs' Endothelial Corneal Dystrophy
PROJECT SUMMARY Fuchs' endothelial corneal dystrophy (FECD) is a degenerative ocular disease affecting 4% of people over 40 and more that >300 million people globally. A ha...
Cell-drones: engineered stem cell nanovesicles as alternatives to exosomes
PROJECT SUMMARY Studies have demonstrated that adult stem cells such as mesenchymal stem cells (MSCs) repair myocardial infarction (MI) or ischemia/reperfusion (I/R) injury by indi...