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99,167 grants found
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Defining the Role of IL-1? in Tungsten-Mediated Cardiovascular Disease
Project Summary/Abstract Inhalation of particulate matter is a known risk factor for the development of cardiovascular disease. Tungsten is an emerging environmental contaminant, p...
Plasma-Based Neuronal Insulin Signaling Exosomes as a Biomarker for Cognitive Impairment in Diabetes
Project Summary Approximately 30% of older adults in the United States have diabetes mellitus (DM). Alzheimer’s disease and Alzheimer's disease-related dementias (AD/ADRD) are...
Evaluation of combination CLK/DYRK (Cirtuvivint) inhibition with PARP inhibition (Olaparib) in BRCA/HRD platinum resistant ovarian cancer
PROJECT SUMMARY/ABSTRACT Approximately 50% of patients with ovarian cancer harbor deficiencies in DNA damage repair with either a germline/somatic mutation in BRCA1/2 or homologous...
Dissecting the immunomodulatory effects of NK cells on immune responses to cancer
PROJECT SUMMARY Current immunotherapies, such as anti-PD-1 immunotherapy, have low objective responses in patients, necessitating the development of novel therapies that boost immu...
Listener training for improved intelligibility of people with Parkinson's disease
PROJECT SUMMARY/ABSTRACT People with dysarthria due to Parkinson's disease (PD) frequently present with reduced intelligibility, which can have significant consequences, inclu...
Regulation of viral-bacterial co-infections by immunometabolism
SUMMARY/ABSTRACT Pseudomonas aeruginosa is a major respiratory pathogen in the pathogenesis of Cystic Fibrosis (CF) and the ineffective immune response to this pathogen is thought...
Next Generation OAEs
Project Summary/Abstract Distortion product otoacoustic emissions (DPOAE) are grossly underutilized in clinical applications. Yet the need for early and accurate diagnosis as well...
Technology for MR brain monitoring
7. Project Summary/Abstract: Technology for MR brain monitoring Magnetic Resonance Imaging (MRI) has been the undisputed standard of care for the detection and diagnosis of neurolo...
Molecular and Cellular Mechanisms of Mutant ASXL1-driven Clonal Hematopoiesis
PROJECT SUMMARY/ABSTRACT Clonal hematopoiesis of indeterminate potential (CHIP) broadly describes the clonal expansion of blood cells derived from hematopoietic stem cells (HSCs) w...
Molecular and cellular characterization of congenital hydrocephalus
PROJECT SUMMARY/ABSTRACT Congenital hydrocephalus (CH) is the leading cause for brain surgery and is associated with marked neurodevelopmental disability. CH is traditionally consi...
Chip phosphorylation stimulates the degradation of mutant transthyretin to attenuate cardiac amyloidosis
PROJECT SUMMARY/ABSTRACT Cardiac amyloidosis can be caused by a mutation in transthyretin (TTR) (e.g. valine 122 to isoleucine, VI) [ATTR- CM] that will aggregate when taken up by...
Neurophysiology of movement transitions in Parkinson's disease with freezing of gait
Abstract Freezing of gait (FOG) is characterized by episodes during which an individual is unable to step, despite intending to do so, and is a common cause of falls, decreased mob...
Alzheimer's Prevention Initiative ADAD Colombia Trial Program
Project Summary/Abstract When the API Autosomal Dominant Alzheimer's Disease (ADAD) Colombia Trial (NCT01998841) was announced in 2012, it launched a new era in AD prevention...
Mathematical modeling of selective vulnerability of genes, cells and network in mouse tauopathy
Project Summary Alzheimer's disease (AD) is a heterogeneous, multifactorial disease that selectively affects certain regions of the brain, e.g. locus coeruleus, entorhinal and...
Elucidating the role of CHI3L1/YKL-40 in Alzheimer’s disease
PROJECT SUMMARY/ABSTRACT Chitinase-3-like protein 1 (CHI3L1/YKL-40) is a well-known biomarker for the early detection of neuroinflammation and Alzheimer’s disease (AD). It acts as...
Alzheimer's Special Care Units in Nursing Homes: Racial and Ethnic Disparities, Resident Outcomes, and State Policies
PROJECT SUMMARY/ABSTRACT Alzheimer's special care units (SCUs) are a promising care model for nursing home residents with Alzheimer's Disease & Related Dementias (ADR...
A Single-Arm Pilot trial for Mitigating Relapse of Severe Problem Behavior
Project Summary/Abstract Over 2 million people in the United States with intellectual and developmental disabilities (IDD) engage in some form of SPB (self-injury, aggression; Croc...
Regulation of mechanically activated Piezo2 ion channels by membrane lipids
ABSTRACT Piezo2 is a non-selective Ca2+-permeable cation channel activated by mechanical force. It is expressed in peripheral sensory neurons of the dorsal root ganglia (DRG) and i...
Translational analysis of a novel intervention to promote healthy aging.
Project Summary Advancing age is associated with an increased risk of type 2 diabetes, which is exacerbated by the high prevalence of obesity in the aged. These disorders are risk...
Impacting Inflammation through Mechanistic Target of Rapamycin (imTOR)
Inflammatory diseases limit healthspan, defined as the length of one’s life spent in good health. We propose an ancillary study to an NIA-funded trial U01AG076941 (EVERLAST) that w...