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99,167 grants found
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Optimizing FACED for robust large-scale activity recording
SUMMARY/ABSTRACTA longstanding challenge in neuroscience is how to monitor neuronal signaling and activity at cellular resolution over a large area/volume with millisecond time res...
Glia in Aging
ABSTRACT Because of the increase in life expectancy, a larger fraction of the population is now elderly and afflicted by age- related diseases with a huge cost for the health care...
A non-canonical role of Caspase-1 in regulating bacterial antimicrobial resistance
Summary Antimicrobial resistance (AMR) is a prominent healthcare threat with an estimated 4.95 million cases associated with bacterial AMR in 2019, and poses a particularly difficu...
Tracking brain dynamics of the acute stress response and neurocognitive mechanisms of chronic alcohol consumption
ABSTRACT Excessive alcohol use is a significant and serious public health problem, with 28.6 million US adults meeting diagnostic criteria for current alcohol use disorder (AUD). T...
Omic Approaches to Factor VIII Inhibitor Development in Hemophilia Patients of Mexican Descent
PROJECT SUMMARY/ABSTRACT Bleeding in Hemophilia A (HA) is currently prevented by regular infusions of therapeutic factor VIII (FVIII) proteins (tFVIIIs). Unfortunately, ~30% of all...
Characterize longitudinal events of oral high-risk human papillomavirus among an at-risk population (CLEAR)
Project Summary/Abstract Males living with HIV are estimated to be at a 2- to 5-fold higher risk of developing human papillomavirus- related oropharyngeal cancer (HPV-OPC) compared...
The role of neuronal hyperexcitability and proteostasis in Alzheimer's disease
Key prodromal events in Alzheimer’s disease (AD) revolve on altered electrical signals and buildup of garbage proteins in vulnerable areas before signs of AD (locus coeruleus, LC))...
A Sleep Hygiene Intervention to Improve Sleep Health in Urban, Latino Middle School Children
Project Summary/Abstract: Sleep is essential for optimal health and development. Poor sleep is associated with impaired functioning and academic performance, and worse health outco...
Elucidating the roles of protein disaggregases and developing enhanced diaggregases to counter diverse protein-misfolding disorders
PROJECT SUMMARY The proper folding of proteins is essential for all life, making aberrant protein folding severely problematic. The protein homeostasis (proteostasis) network is a...
A Functional Analysis of Arginine Methylation
PROJECT SUMMARY/ABSTRACT Our goal is to broadly understand the biological roles of arginine methylation, a very common post-translational modification (PTM). This PTM is deposited...
Developing Trauma Networks of Children, Adolescents, and Young Adults to Examine the "Ripple Effect" of Firearm Injuries
PROJECT SUMMARY/ABSTRACT Firearm injury and death is a public health epidemic that spreads through communities and social networks in the United States much like an infectious dise...
Jawbone is unique: differential responses to growth factor signaling and mechanical loading
ABSTRACT Craniofacial bone health is important to support eating, speaking, breathing, and expressing emotions, and is critical to overall health and quality of life. It is known t...
The Effect of Hospital-Physician Vertical Integration on Costs, Quality, and Utilization for Insured Patients with Multiple Chronic Conditions
Project Summary Improving the quality of care for patients with multiple chronic conditions (MCCs) continues to be a national priority. Concurrently, hospital-physician vertical in...
PROVIDENT: Prepositioning Optimized Strategies for Vaccines and Immunotherapeutics against Diverse Emerging Infectious Threats
The overarching goal of PROVIDENT (Prepositioning Optimized Strategies for Vaccines and Immunotherapeu- tics against Diverse Emerging Infectious Threats) is to deliver “plug-and-pl...
CORE A: Administrative Core
The overarching goal of the PROVIDENT consortium is to develop "plug-and-play" vaccine and therapeutic antibody blueprints for three major groups of emerging enveloped RN...
Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients
PROJECT SUMMARY Over 2.2 million US patients are estimated to have limb loss, with the number projected to rise to 3.6 million by 2050. The current standard for rehabilitation and...
A Plug-and-Play Platform for Continuous Directed Evolution of Nonribosomal Peptide Synthetases
Project Summary Nonribosomal peptides (NRPs) are an abundant class of microbial natural products: small molecules with evolved chemical structures and biological activities that ma...
Refining iPSC-Based Spinal Cord Model Systems by Fabricating Developmentally Programmed Extracellular Matrix Cues
ABSTRACT Cellular reprogramming and induced pluripotent stem cell (iPSC) technologies have provided unprecedented access to the human central nervous system (CNS). They have enable...
7T Vascular and Molecular Imaging of SVD: Sex, Equol, and Risk of Alzheimer’s Disease
ABSTRACT Mixed pathologies of cerebral small vessel disease (SVD) and Alzheimer’s disease (AD) represent the most common cause of dementia in the elderly population. The presence o...
Caregiver–Child Proximity and Attachment Security
PROJECT SUMMARY/ABSTRACT Research has shown that the security of a child's attachment to their primary caregiver is crucial to their social relationships and overall well-bein...