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99,167 grants found
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IL-27 is a protective cytokine during congenital infection
Cytokines govern key cellular processes of pregnancy with both pro- and anti-inflammatory activities. To prevent immune dysregulation at the maternal-fetal interface, cytokines are...
Targeted nutritional approach to restore muscle health and physical activity after sepsis
ABSTRACTSepsis is a potentially life-threatening complication of an infection in critically ill patients and is characterized by severe tissue breakdown, leading to long-term muscl...
N-glycosylation as a regulator of Grp94 Function and Activity
PROJECT SUMMARY Most newly synthesized proteins destined for the cell surface or secretion must transit through the endoplasmic reticulum (ER) for folding and post-translational pr...
Novel enhancement of antibody therapy through NOD2 activation
PROJECT SUMMARY Our long-term objective is to understand the expression and function of monocyte/macrophage Fcγ receptors with a goal of improving antibody-based therapies for dise...
The role of H3K4 demethylases in alcohol-associated liver disease development and resolution
PROJECT SUMMARY Alcohol-associated liver disease (ALD) is a major cause of alcohol related mortality. The specific mechanisms responsible for ALD development and progression are no...
Obesity-Induced Inflammatory Mediators Predict Lack of Response in Patients with Rheumatoid Arthritis Starting Biological Therapies
SUMMARY Obesity-Induced Inflammatory Mediators Predict Lack of Response in Patients with Rheumatoid Arthritis Starting Biological Therapies There is an unmet need to identify predi...
Improving the Processes around Approval, Accrual and Translational Research in Cancer Prevention Trials
ABSTRACT The central goal of this R50 Clinician Scientist Award application is to establish and refine processes that facilitate clinical trials in cancer interception at The Unive...
Conditional Animal Models of mtDNA Disease
Conditional Animal Models of mtDNA Disease: Abstract Mitochondria are critical for metabolism, organ homeostasis, apoptosis, and aging. This wide range of impact is manifested by t...
The fertility, maternal health, and infant health consequences of reproductive policy change
PROJECT SUMMARY The Dobbs v. Jackson Women’s Health Organization Supreme Court decision, which eliminated federal protections for abortion rights, is an unprecedented policy change...
Neural mechanisms of psilocybin-assisted treatment for alcohol use disorder.
Preclinical and clinical research provides strong evidence that psilocybin and other 5-HT2A agonist/partial agonist psychedelics have antiaddictive effects. In a double-blind rando...
Engineering the Premetastatic Niche
Project Summary The majority of breast cancer related deaths occur as a result of metastasis. Once the cancer cells metastasize, the 5-year relative survival rate for breast cancer...
Ionic liquid-based nanoemulsion containing combination antiretroviral drugs for the oral and transdermal treatment of HIV infection
PROJECT SUMMARY Two-drug regimen (2-DR) containing potent second-generation integrase inhibitor (INI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) are currently avail...
Mass Spectrometry-Based Biochemical Analysis of Single Cells Beyond the Global Proteome
PROJECT SUMMARY/ABSTRACT Biological tissues exhibit a high degree of phenotypic heterogeneity and plasticity, comprising many different subpopulations of cells in various states. Q...
Development of antifungal drug resistance in the oral environment over the course of HIV infection
Fungal infections are an increasing human health risk, and the development of fungal resistance to the limited repertoire of available drugs is exacerbating this threat. Five speci...
Organ system cross talk in ischemic heart disease
PROJECT SUMMARY/ABSTRACT This proposal’s objective is to determine whether changing the signaling patterns between the skeletal stem cells (SSCs) and hematopoietic stem cells (HSCs...
Identifying Unique Neural and Inflammatory Mechanisms of Depression in People Living with HIV
ABSTRACT People living with HIV (PLWH) are particularly vulnerable to depression, which negatively affects their quality of life, medication adherence, and even mortality. Nearly 6...
Post-transcription Initiation Control of Gene Expression
Project Summary/Abstract A unifying theme of my research program is to determine how RNA structure regulates gene expression co-transcriptionally by affecting the activity of RNA p...
Chemical Biology Approaches for Investigating RNA-Protein Interactions
Recent studies have shown that RNAs are invariably bound to and often modified by RNA-binding proteins (RBPs). Thus, it is no surprise that RBPs have been found to play key roles i...
Cucurbit[n]uril-Type Molecular Containers
Project Summary / Abstract. The PI is Professor at the University of Maryland College Park since 1998 where he runs a lab focusing on the design and synthesis of new cucurbit[n]uri...
Non-Apoptotic Functions of Caspase-3 in Brainstem Development
ABSTRACT Auditory function relies on highly specialized and precise neuronal connectivity. A significant challenge for the field of auditory neuroscience is to understand how these...