Browse All Grants
99,167 grants found
Showing 1,621 – 1,640 of 99,167 grants
Role of lymphatic endothelial cell NFkB signaling in adult lymph node homeostasis
PROJECT SUMMARY/ABSTRACT The proposed study is significant because we aim to understand the cellular mechanisms that regulate lymph node (LN) maintenance in aging. Aging causes LN...
Complementary and Integrative Health Approaches to Improve TBI Outcomes in Veterans
Project Summary/Abstract Background. Traumatic brain injury (TBI) is one of the most Veteran-centric conditions with few interventions with sufficient evidence and is a top researc...
Mechanistic studies of essential membrane transporters
Membrane transporters are essential for cellular life and are generally understudied compared to other membrane proteins, such as GPCR and ion channels. The long-term goal is to pu...
A Phase 2C Randomized, Controlled, Open-Label Trial of Novel Shortened Regimens for the Treatment of Isoniazid-Monoresistant TB (IMR-TB)
Project Summary/Abstract Isoniazid-monoresistant (IMR) tuberculosis (TB) comprises 1.1 million (11%) of the estimated 10 million new TB cases annually. Recent scientific advances f...
Localized Real-time Sensors for Metabolic Signaling
PROJECT SUMMARY Metabolic pathways function in response to cellular needs, but they also can direct signaling and even influence how our genes are read. If we can understand the un...
Developing and Applying Accessible Computational Technologies for the Design of Small-Molecule Ligands
Project Summary/Abstract Drug discovery is tremendously costly and failure-prone, complicating advances that would otherwise im- prove human health. Computer-aided drug discovery (...
How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changes
Summary RNA Binding Proteins (RBPs) are key regulators of gene expression. The mammalian genome encodes well over 2,000 RBPs, exceeding the number of transcriptional regulators, an...
Analytical approaches to fatty acid oxygenases and their lipid mediator products
Analytical approaches to fatty acid oxygenases and their lipid mediator products Project Summary/Abstract This program focuses on technically challenging questions related to lipox...
Regulation of Germ cell to maternal transition
Abstract The gametes arise either from germ cells or germline stem cells (GSCs), by undergoing differentiation and meiosis. The gametes help launch the next generation by sustainin...
From Genes to Molecules and Back: Expanding the Chemical Space of Microbial and Microbiome Natural Products
ABSTRACT My research has aimed at accessing a previously hidden source of natural products that are encoded in bacterial genomes, and at investigating their structures, functions,...
Resolving the interaction network of cell surface receptors
PROJECT SUMMARY/ABSTRACT Cell signaling is initiated at the plasma membrane (PM), but our understanding of the chemical interactions that regulate membrane protein function is stil...
Impact of nigral and extranigral neurodegeneration on aerodigestive discoordination in a pesticide model of Parkinson's disease
Project summary Swallowing problems in Parkinson’s disease (PD) affect 90% of patients, with significant consequences for quality of life and morbidity, and are resistant to curren...
Cocoa Flavanols for Migraine: A Pilot Study
Project SummaryMigraine, a chronic intermittent headache disorder, ranks in the top five causes for years lived with disability. Approximately 15% of the US population experiences...
Regulation of coagulation and thrombosis by C1 inhibitor
PROJECT SUMMARY Venous thromboembolism is a leading cause of morbidity and mortality in the United States. The contact pathway of coagulation plays an important role in the pathoge...
Efficacy and Safety of Proteolytic Activity-Guided fecal Microbiota Transplantation for Irritable Bowel Syndrome (PRAGMAT trial)
ABSTRACT Irritable bowel syndrome (IBS) is estimated to affect 1 in 6 U.S. adults and results in significant morbidity and health care utilization. Studies over the last decade hav...
Construction of A Lung Cancer Preclinical Model Cross-comparison Platform
Project Summary Preclinical models of lung cancer are essential tools for researchers to understand cancer biology and develop therapeutic strategies. Choosing the most cost-effect...
Long Non-coding RNAs as Therapeutic Targets and Biomarkers of Alzheimer's Disease and Related Dementias
ABSTRACT The effective causative therapies for Alzheimer’s Disease (AD) and related dementias (ADRDs) remain elusive because the patients are often diagnosed at an advanced state o...
Mental health and work-related wellbeing of U.S. obstetrician-gynecologists in a shifting policy climate
PROJECT ABSTRACT U.S. physicians are at risk for poor mental health and work-related wellbeing. Obstetrician- gynecologists (OB-GYNs) are at particularly high risk due to recent ch...
Enhancing accrual and diversity across gynecologic and solid tumor trials
PROJECT SUMMARY/ABSTRACT My clinical research program focuses on improving the lives of all women with gynecologic malignancies. I serve as the lead for the clinical trials program...
Statistical Power Analysis Framework for Multi-Sample and Cross-Platform Spatial Omics Experiments
Abstract Recently, high-throughput spatial omics technologies have made it possible to simultaneously measure close- to-cell-level gene or protein expressions and spatial locations...