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99,167 grants found
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Identifying predictive biomarkers for acute intermittent hypoxia induced motor recovery in persons with incomplete spinal cord injury
PROJECT SUMMARY Spinal cord injury (SCI) results in lifelong sensorimotor deficits, leading to chronic mobility impairments and loss of functional independence. The restoration of...
Promoting Palliative Care for People with Heart Failure: The P3HF Pilot Study
Project Summary Heart failure is a leading cause of morbidity and mortality, projected to affect more than eight million Americans by 2030. Frequent symptoms, hospitalizations, and...
Ensuring Quality in Psychological and Mental Health Services - Service User Quality Assessment EQUIP-SU
PROJECT SUMMARY/ABSTRACT There has been an increase in availability of evidence-based approaches for interventions and mental health service delivery in low-resource settings. In l...
The role of cortisol synthesis in pathogenesis of Hidradenitis suppurativa tunnels
Abstract Hidradenitis suppurativa (HS) is a common, debilitating inflammatory disease characterized by unique pathological features that includes epithelialized tunnel formation. C...
Modulating Endogenous Opiate Signaling to Reverse Stress-Induced Deficits in Reward Processing
Project Abstract Millions of Americans suffer from deficits in reward processing, in the context of psychiatric disorders including major depressive disorder and schizophrenia. Dis...
Development of integrated risk models of genetic and non-genetic risk factors in endometrial cancer across diverse ancestries
PROJECT SUMMARY The incidence of Endometrial Cancer (EC) has been rising, with a notable increase in mortality rates, especially among Black women who face a higher risk of aggress...
Integrative Analysis Methods for the dGTEx Initiative
ABSTRACT This research project aims to develop methods and tools and conduct collaborative research for the integrative analysis of data generated by the Developmental Genotype-Tis...
Improving PrEP outcomes among pregnant women in Botswana with an integrated STI testing and PrEP delivery model
HIV incidence remains high for women in Southern Africa and HIV acquisition risk doubles during pregnancy and postpartum compared to non-pregnant periods. HIV pre-exposure prophyla...
Role of plasma cells in chronic rejection after lung transplantation
SUMMARY Lung transplantation (LTx) is the only life-saving intervention for many patients with end-stage lung disease. The long-term survival after LTx, however, is severely limite...
Social Comparison on Social Media, Depressive Symptoms, and Body Dissatisfaction among Adolescents
PROJECT SUMMARY Social media (SM) has played an increasingly prominent role in adolescents’ daily lives over the past decade, notably coinciding with increased population prevalenc...
FOSL1-super-enhancers define cisplatin-enriched cancer stem cells in HNSCC
Project Summary/Abstract The chemotherapeutic drug cisplatin is a first-line drug for the treatment of many solid tumors, especially head and neck squamous cell carcinoma (HNSCC)....
Precision imaging of the spatial regulators of the hybrid epithelial/mesenchymal state in head and neck cancer
PROJECT SUMMARY Head and neck squamous cell carcinoma (HNSCC), including oral cavity squamous cell carcinoma (OCSCC) is the sixth leading cause of cancer-related mortality, with th...
Next Generation ELQs for Treatment and Once-Monthly Protection Against Malaria
Project Summary / Abstract The Medicines for Malaria Venture (MMV) recently published a “roadmap” for the types of medicines that are needed to support the long-term goal of malari...
Bridging the gap: joint modeling of single-cell 1D and 3D genomics
Advances in single-cell technologies have enabled three-dimensional (3D) genome structure profiling and simultaneous capture of the transcriptome and epigenome within a cell. Quant...
A Novel Nanodrug for Metabolic Disease Treatment
NOTE: You must submit in Word format, not PDF, for eRA to update all the systems.Metabolic health issues such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2...
Targeting Endosomal Receptors for Treatment of Chronic Pain
PROJECT SUMMARY/ABSTRACT Pharmacologic therapy for common forms of chronic pain is ineffective and plagued with side effects. Our long- term goal is to reveal mechanisms of pain/no...
Generation of four-chambered hearts through organoid fusions
Project Summary Congenital heart defects (CHDs) account for 1-2% of all live births in the U.S. More than 90% of these diseases are attributed to defects in heart valves and septum...
Elucidating Cutaneous Mechanosensory Circuits, from Development to Disease
Abstract Our relationship with the physical world is rich, complex, and essential for life. How does the nervous system encode component dimensions of touch –pressure, texture, vib...
Structure, function, and pharmacology of sensory receptors
Sensory receptor ion channels in somatosensory neurons are responsible for the sensory detection of stimuli such as temperature changes and irritants. This information is then tran...
Structural Racism, Neurocognition in Reward Related Decision Making and Substance Use Risk
PROJECT SUMMARY Structural racism (SR) is defined as mutually reinforcing systems, such as income, education and housing, that disadvantage ethnoracially minoritized individuals. S...