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99,167 grants found
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A large scale investigation of the vaginal ecosystem in preeclampsia
ABSTRACT Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of systemic organ damage, often the liver and kidneys. It poses significant clinica...
Mathematical Models for Obesity-Induced Type 2 Diabetes Mellitus and Chronic Wound Healing
Project Summary Aim: To develop a predictive mathematical model of obesity-induced diabetes and chronic wound that includes a realistic representation of the main physiological fac...
Role of cortical GABAergic interneurons in psychedelic drug action
PROJECT SUMMARY Psychedelics are increasingly studied as a potential treatment for mental illnesses. For example, recent clinical trials showed positive outcomes after psilocybin-a...
Environmental and social determinants of mammographic features
Percent mammographic density (PMD) is one of the strongest risk factors for, and is considered an intermediate marker of, breast cancer. Recent wide spread uptake of digital mammog...
Heat Therapy for the treatment of post-acute COVID-19 syndrome
Post-acute sequelae of SARS-CoV-2 infection (PASC) affects 5 out of 10 patients hospitalized for the coronavirus disease 2019 (COVID-19) and ~11% of all adults infected by SARS-CoV...
Sexually Dimorphic Vasopressin Circuits in the Control of Social Interest
Project Summary Disorders of social behavior are increasingly prevalent and pose a substantial burden to society. These disorders often show sex differences in prevalence, expressi...
Developing and Testing a Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency in Latino/a/x Families
PROJECT SUMMARY/ABSTRACT Racial-ethnic discrimination impacts too many Latino/a/x youth and poses a significant threat to their health and well-being, increasing vulnerability for...
Association of DNA Methylation and Stress in Immigrants
PROJECT SUMMARY Immigrants experience significant health disparities which are exacerbated by a heavy stress burden which in turn affects the epigenetic profiles of the immune syst...
Leveraging HIV care infrastructure for implementation of context-adapted liver cancer comprehensive control strategies in Uganda: The LC3 Study
Project Summary: For >18-years, Makerere and Johns Hopkins universities have partnered in Uganda to characterize the epidemiology of hepatitis B (HBV) and HIV co-infection, defi...
#EverythingSucks: Understanding the bidirectional relations between vulnerability to internalizing symptoms in youth (13-20) and social mediacontent
Project summary The proposed research is a longitudinal study in adolescents aged 13-20-years old (N = 1,000) triangulating (1) ecological momentary assessment (EMA) with (2) concu...
Event-level Antecedents of Heavy Drinking Among Bisexual and Heterosexual Women with and without Histories of Sexual Assault
PROJECT SUMMARY Heavy drinking and sexual assault co-occur, and bisexual women are at elevated risk for both. Approximately 25% of bisexual women relative to 11% of heterosexual wo...
PURE-Climate: Identifying and Adapting to Climate Change as a Modifiable Risk Factor for Human Health
ABSTRACT Climate change is the largest global health challenge of the 21st century. Although direct and indirect effects of climate change threaten health worldwide, the impacts wi...
The dynamics of late fetal and neonatal mortality in the Indian context
Project Summary Stillbirths and neonatal deaths are two adverse birth outcomes of critical global health relevance. In 2021, an estimated 1.9 million babies were stillborn, and 2.3...
Short-term environmental exposures and emergency medical service activation in the U.S
PROJECT SUMMARY/ABSTRACT Emergency medical services (EMS) represent a critical facet of the public health infrastructure that will be increasingly stressed by climate change, but t...
Genetic and Epigenetic Controls of Enhancer-Promoter Interactions
Summary In vertebrates, genes directing cell-type specific programs and embryonic development are frequently controlled by cis-acting enhancers located several hundreds of kilobase...
Predictive Gait-Based Biomarkers for Fall Risk in Lower-Limb Prosthesis Users
ABSTRACT Falls are the second leading cause of unintentional death worldwide and lower limb prosthesis users (LLPUs) constitute an exceptionally high-risk group. Over half of LLPU...
Reproductive Healthcare Deserts and Inequalities in Maternal and Infant Health
Project Summary/Abstract Access to reproductive healthcare in the U.S. has become increasingly constrained. Although a growing body of research has focused on identifying state-lev...
New cryo-EM methods to visualize ribosome heterogeneity at single molecule resolution in cells
PROJECT SUMMARY Cryogenic electron microscopy can generate atomic resolution views of cells and is therefore a promising technology to study the molecular mechanisms underlying key...
Control of allelic Gsα expression for regulating hormone signaling
Abstract The α-subunit of the stimulatory G protein (Gsα) mediates the signaling of many hormones, autocrine/paracrine factors, and neurotransmitters. Gsα and its gene, the GNAS co...
Genetic dissection of tissue-specific roles of a circadian NADPH phosphatase
Nocturnin (NOCT) is a NADP(H) phosphatase with highly rhythmic expression peaking in the early dark phase (ZT12) in most tissues in mice. Noct-/- (Noct-KO) mice exhibit a range of...