Browse All Grants
99,167 grants found
Showing 141 – 160 of 99,167 grants
Social Networks for Optimizing Communication Ability in Adult Cochlear Implant Users
Project Summary: One in three adults over the age of 65-years has hearing loss, which has significant negative communicative, cognitive, and social consequences. Although cochlear...
Statistical Methods for Data Integration and Applications to Genome-wide Association Studies
Abstract Large-scale epidemiologic studies, including biobanks and genome-wide association studies (GWAS), are now rapidly leading to the identification of novel risk factors for c...
Implementing a genomics-enabled Learning Health System across Indiana
The goals of this project are to identify strategies to improve the integration of genomic testing, reporting, and use into the clinical workflow of patient care. Over the last dec...
Coordination for Demonstrating Real-world Advancement in Genomics Operations Network (DRAGON)
The Network of Genomics-Enabled Learning Healthcare Systems (gLHS) Coordinating Center will support a national, highly functional, integrated genomic medicine implementation infras...
Vanderbilt Genomic Learning Health System Clinical Site
PROJECT SUMMARY Advances in population-scale genetic data linked to the electronic health record (EHR), along with the rise of learning health systems (LHS) to enable the rapid tra...
The VA Genomics Learning Health System: Implementing genomic medicine across diverse veteran communities
PROJECT SUMMARY The Veterans Health Administration of the Department of Veterans Affairs (VA) is the largest and most diverse learning health system (LHS) in the US, caring for mor...
Empowering Interoperable Genomics-Enabled Learning Health Systems at Scale
PROJECT SUMMARY/ABSTRACT There is significant potential for patient care enabled by genomics to enable transformational improvements in health. However, the actual uptake of genomi...
Making Genomic Medicine Routine in a Rural Healthcare System
Abstract The National Human Genome Research Institute’s 2020 strategic vision charts a path toward an audacious goal – that in 10-years genomic medicine will simply be medicine. To...
YOU GAVE CONSENT BUT DO I HAVE PERMISSION?
PROJECT SUMMARY/ABSTRACT Many people hesitate to contribute their biospecimens and data, including genomic data, for research because they believe that misuse is likely. Biobanks h...
Computational and Statistical Methods to determine variant effect across cell types and development stages
Project Summary Built on the success of the GTEx project, the recently launched dGTEx project will recruit 120 donors to identify genetic variants affecting gene expressions across...
Clinical Expansion of Precision Medicine in the Emergency Department
PROJECT SUMMARY Pharmacogenetic (PGx) testing may be particularly beneficial in patients who visit the emergency department (ED) because most presenting patients are experiencing s...
Small RNA Targeting Approaches to Advance Treatments for Heterotopic Ossification
ABSTRACT Heterotopic ossification (HO) is a condition involving pathologic bone formation in extra-skeletal soft tissues (e.g. tendons, ligaments, muscle) which can occur following...
A National Test of a Culturally Tailored mHealth Integrated Smoking Cessation and Mental Health Intervention for Black Adults with HIV
ABSTRACT People with HIV/AIDS (PWH) are twice as likely to smoke cigarettes compared with the general population. Further,PWH are less likely to quit smoking, likely due to barrier...
Social determinants of health and its impact on the interconnectedness between dental and systemic disease in women
PROJECT SUMMARY The purpose of this administrative supplement proposal is to expand the studies in our parent project R03DE033541-01, Leveraging All of Us data to unravel the inter...
The role of m6A RNA methylation in C9ORF72-ALS/FTD
PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS), an adult onset motor neuron degenerative disease, is increasingly recognized to have clinical, pathological and genetic overlap...
The role of Nerve-fibroblast communication in EDS pain
Classic Ehlers Danlos Syndrome (cEDS) is characterized by skin hyperextensibility and fragility, wound healing problems, and joint hypermobility. cEDS is caused by genetic defects...
Elucidating the neural oscillations of the sensory-discriminative and affective-motivational dimensions of pain.
Project Summary Pain is complex and consists of three dimensions: sensory-discriminative, affective-motivational, and cognitive- evaluative, yet the EEG profile of the cortical act...
Mechanisms and functions of temporal coordination in the entorhinal-hippocampal network
PROJECT SUMMARY Episodic memory involves learning and recalling associations between items and their spatio-temporal context. Those memories can be further used to flexibly support...
Sex dependent dysregulation of parvalbumin interneurons as a pathway to Autism Spectrum Disorder
PROJECT SUMMARY/ ABSTRACT Altered GABAergic interneurons have been documented following genetic and environmental perturbations in Autism Spectrum Disorder (ASD) suggesting that GA...
A Type 1 Hybrid Effectiveness-Implementation Evaluation of a City-Level Transitional Housing Program's Effects on Health, Economic, and Psychologic Outcomes Among People with HIV
ABSTRACT The US is currently on pace to fall short of achieving the goals set by the Ending the HIV Epidemic (EHE) initiative launched by the Department of Health and Human Service...