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99,167 grants found
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Chlamydia trachomatis manipulates (PI)CALM to carry on
PROJECT SUMMARY The CDC estimates that 10% of women between the ages of 15 to 19 test positive for Chlamydia trachomatis and 50-70% of these infections are asymptomatic. This incre...
Transcriptional profiling of proliferative skeletal muscle mononucleated cells coupled with broadband electrical cytometry towards diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome
Transcriptional profiling of proliferative skeletal muscle mononucleated cells coupled with broadband electrical cytometry towards diagnosis of myalgic encephalomyelitis/chronic fa...
Preventing Adolescent Suicide Mortality: Exploring Barriers and Facilitators of School Officials' Participation in Child Death Review Meetings
Project Summary Suicide the second leading cause of death among adolescents ages 14-24; in 2022, approximately 18 adolescents died each day from suicide. Child death review (CDR) t...
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
Project Summary Abstract Electronic cigarette (e-cigarette) use among adolescents is an emerging public health problem. In 2020, 19.5% of high school students and 4.7% of middle sc...
Multi-parametric anthropomorphic MRI Phantoms technology for reliable and reproducible structural and quantitative MRI
Abstract Our parent R01 titled “Multi-parametric anthropomorphic MRI Phantoms technology for reliable and reproducible structural and quantitative MRI” aims to develop materials, t...
Personalized Auricular Point Acupressure for Chronic Pain Self-Management in Rural Populations
PROJECT SUMMARYDespite a range of therapeutic approaches, chronic musculoskeletal pain (CMP) persists at a high rate, creating a public health burden. Our long-term goal is to incr...
Mechanisms of Immune Protection Against Respiratory Viruses
PROJECT ABSTRACT - OVERALL The SARS-CoV-2 pandemic highlighted the urgent need for better understanding of the mechanisms controlling broadly protective immune responses to rapidly...
Core A - Administrative Core
PROJECT ABSTRACT - CORE A (ADMINISTRATIVE CORE) The Administrative Core (Core A) will serve as a central entity to manage, coordinate, and supervise the Washington University (Wash...
Project 1
PROJECT ABSTRACT - PROJECT 1 The induction of immune memory is the basis of vaccination, which arguably is the single most impactful medical intervention in human history. Nonethel...
Project 2
PROJECT ABSTRACT – PROJECT 2 SARS-CoV-2 and influenza A viruses are human pathogens with broad geographic range that cause pandemics and jeopardize human health. While the rapid de...
Adaptation of a digital health HIV prevention intervention for Black heterosexual couples in New York State
ABSTRACT / SUMMARY Current HIV/STI prevention interventions for Black heterosexual / opposite-sex (BHOS) couples in the US require an in-person modality and focus on specific subgr...
Regulation of inflammation by nociception
Project summary Maintenance of homeostasis at barrier tissues is essential for mammalian health. At these sites, the concerted communication of different cell lineages is central f...
Testing Oral Nicotine Pouches to Reduce Smoking-Related Cancer Disparities in Appalachia
PROJECT ABSTRACT Rural Appalachian counties have the highest cancer incidence and mortality rates in the United States (US). While most cancer disparities are narrowing between App...
Altering electron-induced radiolysis to optimize cryo-EM/ET imaging
PROJECT SUMMARY Living cells have a complex and often precise organization in space and time. Determining the three- dimensional structure of proteins and other biomolecules, as we...
A Motivation-Based Adolescent Vaping Typology to Inform Cessation Interventions
PROJECT SUMMARY/ABSTRACT Since the introduction of e-cigarettes in the U.S. in 2007, there has been a dramatic increase in the prevalence of e-cigarette use among adolescents. Thes...
Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services
PROJECT SUMMARY Autism is a highly prevalent neurodevelopmental condition, affecting 1 in 36 youth. The annual cost in the U.S. of autism was $223 billion in 2020 and is estimated...
Synthetic Melanin for Accelerating Wound Repair
PROJECT SUMMARY Mustard gas causes severe epithelial and deep tissue injury resulting in blisters, pain, delayed wound healing, and scarring. The complex mechanism of tissue damage...
The hemoglobin beta subunit regulates chromatin and transcription to adapt to metabolic demands
Abstract Several studies have reported that hemoglobin is expressed in neurons in the rodent and human brain, however the function of hemoglobin in these cells hasn't been cle...
ComPASS Health Equity Research Hub at Yale
ABSTRACT The Community Partnerships to Advance Science for Society (ComPASS) Health Equity Research Hub at Yale (Yale ComPASS Hub) will support select community-led health equity s...
A Superiority Trial of Radiofrequency Ablation for Low Back Pain
Low back pain is the #1 contributor to years lived with disability (CLBP; pain persisting for ≥3 months). An obstacle to reducing the societal burden of CLBP is that most treatment...