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99,167 grants found
Showing 1,501 – 1,520 of 99,167 grants
PFAS increases susceptibility to infection-mediated PTB
PROJECT SUMMARY Preterm birth (PTB) and related intrauterine growth retardation (IUGR) affects 15 million babies a year globally (~11% of births) and is linked to chronic diseases...
Statistical Methods for Addressing Disease Under-diagnosis Using Electronic Health Record Data
Under-diagnosis occurs when an individual living with a disease condition has not received a diagnosis. Reasons for under-diagnosis are often complex and context specific, and the...
Risk for Severe/Profound Intellectual Disability in Down Syndrome
Abstract Down syndrome (DS) predisposes individuals to a wide range of cognitive outcomes, with some individuals acquiring more advanced cognitive skills and others demonstrating s...
Advancing novel cancer preventive and therapeutic strategies across the modern NCI clinical trial networks
PROJECT SUMMARY/ABSTRACT Guided by my 16-years of experience and leadership in the NCI-sponsored clinical trial networks (NCI-CTNs), this R50 Research Specialist award offers criti...
In vivo assessment of variants of uncertain significance in the intellectual disability gene ANKRD17
Neurodevelopmental disability can be caused by pathogenic variants in any one of numerous genes, many of which are still being identified. The identification of a variant of uncert...
Longitudinal assessment of the role of interoception in chemotherapy-induced peripheral neuropathy (CIPN) along the cancer chemotherapy continuum
PROJECT SUMMARY/ABSTRACT Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting toxicity that affects over 65% of patients receiving taxane- or platinum-based...
Disseminating Effective Reproductive and Sexual Health Programs
Disseminating Effective Sexual Health Programs in Schools using iCHAMPSS PROJECT SUMMARYDespite a steady decline in the U.S., teen births continue to be a public health problem, pa...
Core B - Clinical Core
PROJECT ABSTRACT – CORE B (CLINICAL CORE) The Washington University Cooperative Center on Human Immunology (WashU-CCHI) Clinical Core (Core B) combines the resources of two highly...
Core C - Proteomics Core
ABSTRACT – CORE C Core C will be responsible for the in-depth determination of the molecular composition, temporal dynamics and functional properties of the antibodies that compris...
Developing and Validating a Measure of Patient-centered Peripartum Contraceptive Care
PROJECT SUMMARY ABSTRACT Background: Contraceptive care is an essential component of maternity care. While patient-centeredness is a key aspect of the quality of contraceptive care...
Theranostic DLL3/PSMA-bi-specific CAR-T cells for prostate cancer therapy
SUMMARY Our overarching goal is to develop a novel theranostic prostate-cancer-specific CAR-T cell paradigm that will allow for successful targeting of antigen-heterogeneous neuroe...
Role of a novel G protein-coupled mast cell receptor-mediated pathways in periodontal disease
Summary: Periodontitis is a chronic inflammatory disease in which a highly orchestrated host-microbial interaction leads to the destruction of the tooth-supporting structures inclu...
Childhood Adversity and Biological Mechanisms of Accelerated Aging
Project Summary/Abstract Early life adversity, including childhood maltreatment and other traumas, is a major risk factor for a host of health conditions, including psychiatric dis...
Multi-level mechanisms and predictors of irritability: An innovative approach bridging laboratory and real-world measures
PROJECT SUMMARY/ABSTRACT Irritability, an increased propensity to experience anger and frustration, is among the most common presenting complaints in child psychiatry. Severe irrit...
Illuminating the Molecular Logic of Mammalian Synaptic Circuit Assembly
PROJECT SUMMARY/ABSTRACT Synapses are the fundamental signaling components of the nervous system and mediate trans-neuronal information transfer. Brain functions require the precis...
Characterizing the requirement of the mycobacterial BrkB ortholog in TB pathogenesis
Project Summary / Abstract: Due to the rise of antibiotic resistant tuberculosis and the long treatment time of current anti-tuberculosis therapies, there is an immediate need for...
Deciphering The Evolutionary and Biological Impact of Human Admixture
Project Summary Admixture is a vital evolutionary process that profoundly shapes human genetic diversity and health. Current evidence suggests that admixture is ubiquitous througho...
Inclusion of Diverse and Medically Underserved Populations in the Design and Implementation of the PREMMplus Patient-Facing App
Project Summary/Abstract The increasing use of genetic testing and the development of syndrome-specific risk models has transformed hereditary cancer risk assessment. We were funde...
Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function
Summary/Abstract Genome-wide association studies (GWAS) have associated hundreds of thousands of genetic variants with human disease and complex traits. 90% of associated variants...
Substantia nigra circuits in instrumental action
Project Summary / Abstract Degeneration of dopamine neurons in the substantia nigra pars compacta (SNc) and resulting pathophysiology in basal ganglia circuits are central to the c...