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Defining Actionable Opportunities in Malignant Phyllodes via Genomic Profiling
ABSTRACT Malignant phyllodes tumors (MPT) are extremely rare primary breast cancers, which are globally understudied due the infrequency of the diagnosis and to the unfamiliarity w...
Integrative proteogenomics for elucidation of tumor-specific cell surface proteomes in ultra-rare cancers
Project Summary Despite advances in treatment, sarcomas like rhabdoid tumors and desmoplastic small round cell tumors (DSRCT) remain challenging, with frequent therapy resistance a...
Inflammation and EGFR crosstalk in HNSCC Therapy
Project Summary Given the importance of oncogenic epidermal growth factor receptor (EGFR) signaling for tumor cell proliferation in head and neck squamous cell carcinoma (HNSCC), w...
Insulin and Immune Mechanisms in Obesity-Induced Renal Disease
Prepubertal childhood obesity (PPO) has emerged as an epidemic and major health problem in the United States. Recent studies suggest that PPO is associated with increased risk of r...
Oocyte mitochondrial activity regulates embryo telomere reprogramming
PROJECT SUMMARY Telomeres, the repetitive DNA at the ends of chromosomes, shorten during every cell division except in very exceptional circumstances; in particular, rapid telomere...
Pathobiology of autoimmune-mediated diffuse podocytopathy
Project Summary/Abstract Minimal change disease and primary focal and segmental glomerulosclerosis are morphologic expressions of a diffuse podocytopathy of to date unknown cause,...
Glycinergic inhibition in the ventral brainstem
Project Summary The autonomic nervous system (ANS) regulates multiple aspects of energy homeostasis including food intake, energy expenditure, lipid metabolism, and glucose homeost...
Investigating the role of gut-derived extracellular vesicles in PTSD following TBI
Abstract Veterans and the general public with traumatic brain injury (TBI) have a high risk of developing posttraumatic stress disorder (PTSD) and other psychiatric disorders, such...
Bacteriophage strategies to lyse bacterial cells
Project Summary Bacteriophage, or phage, infect and kill bacterial cells. At a programmed time, phage use a tailored suite of proteins to release newly built virions by lysing the...
3/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
A clinical decision support tool to understand the survival benefit of kidney transplantation in candidates with a history of cancer
PROJECT SUMMARY / ABSTRACT: Survival with end-stage kidney disease (ESKD) has improved in the last decade alongside the trend of an aging population with greater risks, including c...
5/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
Skeletal Myosin-Binding Protein C: Defining Function Across Scales Using a Zebrafish Model System.
Myosin-binding protein C (MyBP-C), a thick filament associated protein of vertebrate striated muscle, is a key modulator of muscle contractility. Multiple distinct skeletal muscle...
Methods to build and annotate tissue atlases using spatial genomic data
Project Summary/Abstract Single-cell spatial technologies hold the promise of understanding spatially-resolved cell state and discovering how cells interact locally to create compl...
Impact of dietary lipids on pancreas cancer initiation and progression
PROJECT SUMMARY Despite advances in cancer treatment, the five-year survival rate for pancreatic ductal adenocarcinoma (PDA) is 12%. Obesity has been linked to PDA risk epidemiolog...
Fimepinostat, Combination HDAC and Pi3-kinase Inhibitor Tumor-Directed Therapy for Cushing Disease (IND 168501 - 07/31/2023)
Abstract Cushing Disease (CD) a life-threatening “orphan disease” with an annual US incidence of ~8 cases per million. It is caused by an adrenocorticotropic hormone (ACTH)-secreti...
Whole Protein Arrays to Detect Antimicrobial Antibodies Associated with Triggering and Progression of Islet Autoimmunity in TEDDY
Abstract Type 1 diabetes (T1D) is a multifactorial disease caused by a complex interplay of genetic and environmental factors. The genes that mediate disease susceptibility have la...
Functional roles of DDX41 in the homeostasis of G quadruplexes in erythropoiesis
Project Summary Increased evidence started to show that many germline mutations predispose individuals to myeloid neoplasms, including myelodysplastic syndromes (MDS). One of these...
4/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
Determining the mechanisms of extracellular vesicle release, function, and clearance
Project Summary/Abstract Cells release extracellular vesicles (EVs) that carry signals to alter cell fate or metabolism, promote invasive behavior, or modulate the immune response....