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Linkages between HIV/STI prevention and syndemic behaviors in high risk youth: Common factors and unique pathways
ABSTRACT Current data continue to reflect that the likelihood of being infected with HIV is elevated among certain groups who have historically been less well represented in resear...
Efficacy and Mechanisms of Media and Storybook Interventions to Promote Children’s Early Literacy Skills via Caregiver Engagement
Project Summary/Abstract This project aims to determine whether a media-based intervention targeting low- socioeconomic status (SES) preschoolers and their caregivers can improve c...
ER-phagy regulation of immune response: mechanisms and significance
Despite increased clinical awareness, sepsis remains a leading cause of death and high healthcare costs worldwide. Sepsis is a life-threatening condition characterized by an exagge...
Role of TAM receptors in modulating humoral immunity against parasitic infections
ABSTRACT Unlike many infectious diseases, naturally acquired immunity against Plasmodium do not represent durable sterilizing immunity. While the gradual acquisition of protective...
A Prospective Study of Persistent Symptoms of Lyme Disease
ABSTRACT: OVERALL Despite years of research, there is no diagnostic test for post-treatment Lyme disease syndrome (PTLDS); there is no consensus treatment for PTLDS; there is no ag...
Administrative Core
ABSTRACT: ADMINISTRATIVE CORE The Administrative Core will be based in the Department of Molecular Biology and Microbiology at the Tufts University School of Medicine and will prov...
Clinical Coordination Core
ABSTRACT- CLINICAL COORDINATION CORE The Clinical Coordination Core (CCC) provides oversight for efficient and optimal enrollment of patients with early Lyme disease as manifested...
Diagnostics Core
ABSTRACT- DIAGNOSTIC CORE The Diagnostics Core provides comprehensive laboratory testing for Lyme disease in a CLIA-certified clinical laboratory setting. Its purpose is to provide...
Epidemiology of Post-Treatment Lyme Disease Syndrome
ABSTRACT: Project 1, The Epidemiology of Post-Treatment Lyme Disease Syndrome A proportion of early Lyme disease patients who have been treated with standard antibiotic regimens ex...
Enhancing efficacy of virus-specific T cell therapy following hematopoietic stem cell transplantation by CD52 knockout
Viral infections are common and can be severe in immunocompromised patients, including those undergoing hematopoietic stem cell transplantation (HSCT) or solid organ transplantatio...
Facilitating the Implementation of Population-wide Genomic Screening across Diverse Populations and Settings (FOCUS)
PROJECT SUMMARY Population-wide genomic screening (PGS) for Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, and Familial Hypercholesterolemia offers great promise in...
Dopaminergic Control of Glial Cells in Prefrontal Cortex Functions
Project Summary Recent research in the study of brain functions is highlighting the important role of glial cells in several human neurological and psychiatric disorders. The dopam...
Monocyte and Macrophage Functional Evolution in Kidney Transplantation
Access to kidney transplantation as a cure for end-stage kidney disease is severely limited by donor organ shortage. Exacerbating this shortage is the need for re-transplantation r...
Neural circuit mechanisms in observational spatial working memory
PROJECT SUMMARY Observational learning is a type of social learning and a fundamental cognitive behavior in humans and social animals. How neural circuits in the brain enable this...
Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
PROJECT SUMMARY Among the ~2.5 million persons who develop incident tuberculosis (TB) in sub-Saharan Africa annually, about one in five does not complete treatment, even though hig...
Ethical Considerations in The Design and Testing of Back-Support Exoskeletons
Project Summary Low-back pain is the primary cause of disability across the world, and over 80% of workplace injuries also occur to the lower back. Wearable robotic technologies, s...
Defining pediatric intestinal failure natural history
Pediatric intestinal failure (IF) is a rare condition that affects under 25,000 individuals in the United States. Children with IF require parenteral nutrition to provide enough ca...
Progressing toward clinical trial readiness in CCHS: Natural history study to incorporate patient voice, harmonize clinical and registry data, and standardize assessments
Abstract Congenital central hypoventilation syndrome (CCHS) is a rare and severe neurocristopathy caused by PHOX2B gene mutations. CCHS is characterized by profound hypoventilation...
Novel methods for detection of mosaic chromosomal alterations
Project Summary Somatic mosaicism results from the accumulation of mutations over time, leading to a unique genotype in every cell. These mutations can be as small as a single base...
Using digital photovoice to explore the relationships between social media content and suicidality among transgender adolescents
Project Summary/Abstract Social media has a complex influence on mental health. It can contribute to bullying and harassment, which may result in loneliness, depression, and suicid...