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99,167 grants found
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Retinal biomarkers in monogenic vascular cognitive impairment and dementia
Project Summary/Abstract The project will enroll 180 persons with the autosomal dominant gene for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoenceph...
Phase 2a/2b Study Emapalumab: A Window of Opportunity in Pediatric Aplastic Anemia
Abstract Acquired aplastic anemia (AA) is a life-threatening disorder caused by an autoreactive T-cell mediated destruction of hematopoietic stem cells resulting in the inability t...
Hormonal contraception choice and safety among people with sickle cell disease
Project Summary Estrogen-containing hormonal contraception and injectable progestin-only contraception have been associated with venous thromboembolism (VTE) and stroke in the gene...
Bioengineered 3D tooth germs for tooth regeneration in vitro and in vivo
Project Summary Dental decay and tooth loss are common problems. Bridges and implants are the primary treatment options but cannot completely restore the tooth biology and function...
Optimizing singlet oxygen dosimetry for photodynamic therapy (PDT)
Optimizing Singlet Oxygen Dosimetry for Photodynamic Therapy (PDT) Abstract The overall objective of this project is to optimize clinical singlet oxygen (1O2) dosimetry (SOD) via t...
Modeling a national Graduated-BAC per se policy for 21-24 y/o drivers to reduce alcohol impaired driving injury and fatal crashes
PROJECT SUMMARY The national comprehensive societal cost from alcohol-impaired crashes is estimated at over $348 billion, with $296 billion attributable to ≥ .08 BAC cashes. In the...
Mechanisms of intracellular iron dysregulation in kidney fibrosis and reno-protective strategies
Chronic kidney disease (CKD) affects 10-15% of the population worldwide.More than 37 million people are estimated to have CKD in the US, and 2 in every 1000 Americans need dialysis...
The Functional Role and Neural Basis of Rapid Turns in Olfactory Search Behavior
Summary When searching their environment for food, animals often switch from making random changes in direction to reflexively orient upstream when they smell an attractive odor, f...
Examining maternal lifetime exposure to structural racism and metabolomics in neonatal dried blood
Structural racism (SR) denotes the multidimensional and systemic oppression of Black individuals in the US. Residential segregation is a central component of SR. According to exper...
Targeting P21 positive senescent cells for alleviating TMJ degeneration
Abstract Temporomandibular Joint (TMJ) degeneration is a painful and debilitating disease of the synovial joint, affecting over 20 million people in the United States. Obesity, adv...
Mechanism of Myocardial Fibrosis Induced by Mitral Valve Prolapse
Mitral valve prolapse (MVP) affects 1 in 40 individuals and is complicated in 30-35% by ventricular arrhythmias that increase risk for sudden cardiac death (SCD). Such arrhythmias...
Osteocytic mechanisms required for spatiotemporal control of bone quality
SUMMARY Bone fragility cannot be explained by bone mineral density (BMD) alone and also results from defects in the material properties of the bone matrix, termed bone quality (BQ)...
P7C3 based small molecule for Heart failure treatment
Summary NAD+ is biosynthesized mainly through the salvage pathway and is central for cellular homeostasis and energy production. Deficiency of NAD+ results in disruption of cellula...
High-resolution approaches to dissect the role of subcellular redox circuits in vivo
Project Summary Metastasis is the leading cause of death for cancer patients. Oxidative stress, characterized by excessive exposure to reactive oxygen species (ROS), kills most met...
Metalloproteins: evolution, catalysis and material design
Project 1: Recently, we have demonstrated for the first time the predictive link between NMR chemical shift perturbation, protein dynamics and probability of finding productive mut...
Cardiovascular and thermoregulatory consequences of severe burn injuries
Within the United States, 500,000+ individuals are enduring the long-term consequences of severe burn injuries covering 20% or more of their body surface area, with upwards to 11,0...
Essential functions of OGT in host defense mechanism
Project Summary Cellular metabolism instructs immune cell functions in both physiological and disease conditions. Activation of immune cells in response to invading pathogens induc...
3/5- Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
Delineating the mechanisms of filopodia-mediated intracellular delivery of siRNAs via peptide carriers towards the development of a molecular targeted therapy for oral cancer
The use of exogenous nucleic acids has great potential for therapeutic applications in numerous diseases, including cancer. However, the delivery of nucleic acids is challenging, a...
Does the maternal environment during viral infection and inflammation direct fetal T cell development and function?
Project Summary Increasing evidence suggests that maternal inflammation/infection-induced immune activation (MIA) during pregnancy can lead to sustained, long-lasting changes in im...