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Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth with Type 1 Diabetes
PROJECT SUMMARY / ABSTRACT Type 1 diabetes (T1D) is one of the most common chronic illnesses of childhood. The involved treatment regi- men, including daily insulin administration/...
Sudden Death Risk Assessment and Mechanistic Insights in Arrhythmic Mitral Valve Prolapse Using Cardiac MRI and Circulating Proteomic Biomarkers
Project Summary: Mitral valve prolapse (MVP) is a common valvulopathy affecting 2-3% of the population and nearly 200 million individuals globally. While it is often benign, a subs...
Common Fund Gene Utility Compendium: A Systems Biology Resource to Explore Tissue-Specific Functional Genes and Druggable Genomes
PROJECT SUMMARY Tissue-specific genes are underutilized as disease targets. Tissue-specific genes show narrow expression, play key roles in maintaining tissue homeostasis and are t...
Ultra-high resolution 3D genome maps for multiple human tissues
Abstract The diversity of human tissues and cell types is controlled by differential regulation of gene expression. Enhancers are the primary units of gene expression control in hu...
Pilot trial comparing transpyloric to gastric feeding in very preterm infants with bronchopulmonary dysplasia
PROJECT SUMMARY/ABSTRACT Bronchopulmonary dysplasia (BPD), or infant chronic lung disease, is among the most devastating complications of preterm birth. BPD affects half of survivi...
Variant impact prediction on Common Fund data sets towards drug repurposing for rare genetic diseases
PROJECT SUMMARY Despite advances in our understanding of rare genetic diseases and their causes, only 8% of these diseases have targeted drugs. Much of this arises from the disconn...
Toward Deep Learning Techniques for Cell-Type and Spatial Resolution Estimation of Regulatory Networks
Understanding and decoding the intricacies of gene regulatory networks is crucial in genomics for insights into gene expression and cellular functions. Traditionally, research in t...
Synergizing Common Fund Data from MoTrPAC and LINCS for the Discovery of Novel Exercise Mimetic Drugs
PROJECT SUMMARYExercise represents one of the most powerful and beneficial interventions for health and wellness, though patients with and without chronic disease struggle to exerc...
Development of a first-in-class complement inhibitor for treating complement-mediated hematologic diseases
ABSTRACT Excessive complement activation causes many diseases especially hematologic diseases such as paroxysmal nocturnal hemoglobinuria (PNH) and autoimmune hemolytic anemia (AIH...
GeneSight: Advancing Insights into Complex Genetic Traits through CFDE-Enhanced Knowledge Graphs
Abstract: Unraveling the molecular mechanisms that link SNPs and genes identified in GWAS studies to the disease is a challenge that must be overcome to translate these genetic dis...
Leveraging Heterogenous Common Fund Data Sets and Beyond for Identifying Lung Cancer Subtypes
Scientific Abstract As the leading cause of cancer death in the United States, lung cancer accounts for about 20% of all cancer deaths. While there are two major types of lung canc...
Optimizing Pain Treatment In Children On Mechanical ventilation (OPTICOM)
PROJECT SUMMARY/ABSTRACT More than 24,000 children develop acute respiratory failure (ARF) and require invasive mechanical ventilation (MV) – an intrusive, painful, yet lifesaving...
Implementing and Personalizing Best-In-Class Opioid-sparing Pain Management for Major Inpatient Surgeries in Children
PROJECT SUMMARY: The multicenter PRECISE Analgesia (Prospective Randomized Evaluation of Analgesia for Cardiac and Idiopathic Scoliosis Spine Fusion Elective Surgery in Children) t...
Trans Nasal Transesophageal Echocardiography
Project Summary: Transesophageal echocardiography (TEE) is an essential diagnostic tool in cardiology. There are over one million TEEs performed annually in the United States. A ma...
Efficacy of intravenous sub-dissociative ketamine versus intravenous morphine in children with acute pain.
Project Summary Pain is one of the most common reasons for children to visit an emergency department (ED) and is associated with short- and long-term consequences when inadequately...
Immunology of Post-Treatment Lyme Disease Syndrome
ABSTRACT: Project 2, Immunology of Post-treatment Lyme Disease Syndrome Similarities between symptoms of Post-Treatment Lyme Disease Syndrome (PTLDS) and symptoms seen with fibromy...
Shapeshifting Cyclic Peptides as Single Molecule Polypharmacological Drugs
SUMMARY/ABSTRACT For many years, scientists have been trying to find new therapeutic drugs. However, small molecules are still imperfect tools for influencing human physiology. The...
Understanding Sensorimotor Control Through Realistic Neuro-Biomechanical Simulation
Summary/Abstract The brain evolved to move the body, i.e., to implement sensorimotor control. Understanding the brain, then, is inextricably linked to understanding how it coordina...
CRCNS: Dissection and control of cognitive thalamocortical dynamics
PROJECT SUMMARY (See instructions): Cognitive flexibility, the ability to mentally switch between different thoughts and action plans, is critical for survival in a rapidly changin...
Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy
ABSTRACT Over 38 million people worldwide are living with HIV, and the non-communicable complications of HIV infection are a significant global health concern. People with HIV (PWH...