Browse All Grants
99,167 grants found
Showing 1,401 – 1,420 of 99,167 grants
Uncovering Heterogeneity in Individual Treatment Responses via Causal Machine Learning
PROJECT SUMMARY/ABSTRACT Clinical recommendations for the management of diseases are mostly based on the average treatment effects observed in randomized controlled trials. However...
Evaluating a Multilevel Intervention to Increase Colonoscopic Follow-up after Abnormal Stool-based Colorectal Cancer Screening in a Community Safety-Net Setting
Project Summary/Abstract Colorectal cancer (CRC) is the second most common cause of cancer-related mortality in the United States (U.S.). Although several effective prevention and...
1/5 Clinical Outcome Prediction of Psychosis from EHRs (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
Zwitterionic polyethylene glycol for therapeutic delivery
Project Summary Biologic drugs and nanomedicines with conjugated polyethylene glycol (PEG) show extended circulation in the blood, increasing therapeutic efficacy. The U.S. FDA has...
Scalable functional analysis of neuropsychiatric risk genes with spatially integrated in vivo Perturb-seq
Although numerous genes and loci associated with autism spectrum disorder and neurodevelopmental delay (ASD/NDD) have been identified through genome sequencing efforts, the precise...
Alcohol impairs the HSPC response to septic infection
Project Summary/Abstract Alcohol abuse increases the host risk of developing serious infections, particularly septicemia/sepsis. Neutrophil granulocytes constitute the first line o...
Planning grant for clinical trial of implicit bias mitigation training for clinicians
Hypertension is a leading cardiovascular disease risk factor in the US and a leading cause of stroke, kidney disease, and heart failure. Compared to White individuals, it is more p...
Genetic Map of the Mammalian Cell Response to Environmental Stress
A wide variety of environmental stressors, from pesticides to common anticancer chemotherapies, result in protein damage. This damage underlies diseases such as cancer and neurodeg...
FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
PROJECT SUMMARY/ABSTRACT Lynch syndrome (LS), the most common inherited cause of colorectal cancer (CRC) affecting ~1.2 million Amer- icans, carries 3-8x higher lifetime CRC risk t...
1/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
Using STRAINS, a big data method that analyzes the spatiotemporal distribution of cell phenotypes, to investigate mechanotransduction pathways in injured cartilage
PROJECT SUMMARY Osteoarthritis is a leading cause of disability in the US affecting almost 30 million people at an annual cost of $128 billion. Initiation of osteoarthritis is tied...
Role of cholesterol in the pathogenesis of hepatic encephalopathy
Liver cirrhosis results from long-term continuous damage to the liver leading to irreversible buildup of scar tissue impairing liver function. Cirrhosis can occur as a consequence...
5/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
A Multi-level Intervention to Reduce Total Thyroidectomy Overuse for Low-Risk Cancer
PROJECT SUMMARY The majority of patients with low-risk thyroid cancer undergo total thyroidectomy – the riskiest treatment option. Safer, less invasive alternatives offer patients...
2/5-Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
Digital Interventions to Study and Influence the Alcohol-Atrial Fibrillation Connection
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Alcohol is the most commonly consumed drug in th...
Multi-method investigation of social facilitation of alcohol effects and alcohol misuse in young adults
PROJECT SUMMARY Young adulthood is a critical period for alcohol initiation and changes in alcohol use patterns, including increased risk for alcohol misuse and alcohol use disorde...
Optimizing Preimplantation Kidney Transplant Biopsy Interpretation with Artificial Intelligence Assistance - Resubmission - 1
PROJECT SUMMARY Less-than-ideal kidneys recovered from deceased donors continue to be discarded at a rate of 40-50%, but evidence shows that many discarded kidneys could have yield...
Hepatic insulin resistance integrates T2D and NAFLD
This proposal investigates mechanisms that combine T2D (type 2 diabetes) with NAFLD (non-alcoholic fatty liver disease), which progress during chronic hepatic IR (insulin resistanc...
Contribution of antibodies targeting PLP1-anchored membrane domains to multiple sclerosis pathogenesis
Project Summary A role for B-cells in multiple sclerosis (MS) pathogenesis has been implicated by clinical, histopathologic and immunologic studies. The precise role they play in p...