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99,167 grants found
Showing 121 – 140 of 99,167 grants
Building Healthy Habits for Heart Health
PROJECT SUMMARY Vascular calcification is the major precursor to cardiovascular disease and is further exacerbated by chronic kidney disease. Black or African Americans are more th...
Robust and precise imaging of infant brain development with magnetic resonance imaging
Project Summary/Abstract: This research proposal aims to develop advanced in vivo magnetic resonance imaging (MRI) technologies for studying infant brain development. The objective...
Guidelines for processing and storing liquid biopsy samples for functional assays in research and clinical testing.
PROJECT SUMMARY The World Health Organization predicts that cancer diagnoses will increase to 22 million per year within the next two decades, with a corresponding 70% rise in canc...
Role of Lipid Droplets in Macrophages and their Consequences in Lupus
PROJECT SUMMARY/ABSTRACT Lipid metabolism, including lipid synthesis and degradation, is essential for the immune system and cellular functions. Lipid droplets (LDs) are major lipi...
Trigeminal Nerve Stimulation for Prenatal Alcohol Exposure
ABSTRACT/SUMMARY Prenatal alcohol exposure (PAE) is a severe, life-long neurodevelopmental disorder. It afflicts hundreds of thousands of children in the US and worldwide. The high...
Transcriptional potency in early embryos
This project seeks to identify and test mechanisms that establish the transcriptional regulatory potency of early embryos. The relationships among DNA accessibility, nucleosome lab...
Implications of midlife alcohol use for risk of dementia in male and female twins: Unique contributions and interactions with APOE4
Abstract The purpose of this study is to examine alcohol consumption as a modifiable risk factor for Alzheimer's disease and related dementias (ADRD). Approximately 40% of ris...
Non-educational sources of later-life cognitive reserve and resilience among older adults with and without formal education in India
PROJECT SUMMARY By 2050, over 75% of cases of Alzheimer’s disease and related dementias (ADRD) are expected to occur in low- and middle-income countries (LMICs), such as India, whi...
Engaging Aging Minds: Labor Force Participation, Stimulating Activities, and Cognitive Aging Across Diverse International Settings.
PROJECT SUMMARY Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) present profound global challenges, particularly for rapidly aging populations in...
Guanfacine for women with AUD: A multisite study using a telehealth approach
ABSTRACT There is currently a dearth of FDA-approved medications developed specifically for women with alcohol use disorder (AUD). This represents a major public health concern for...
Effects of Pain on Laboratory Drinking Topography and Daily Drinking in People with Chronic TMD Pain
Project Summary Chronic Temporomandibular Disorder (TMD) is associated debilitating pain and dysfunction of the muscles of the jaw, the temporomandibular joints, and related struct...
Effectiveness of a multilevel integrated intervention for LDCT lung cancer screening and smoking cessation among African Americans
PROJECT SUMMARY/ABSTRACT African Americans have both the highest incidence and mortality of lung cancer compared to any other racial/ethnic group. A possible explanation for this d...
Feature Engineering to Infer Proteomic Changes from mRNA Data
PROJECT SUMMARY Proteins are the molecules that carry out the majority of biological function. Although mRNA levels can be measured at scale and have been transformative for unders...
The Moana Project: The Connection Between Pacific Islanders and Genetics
PROJECT SUMMARY/ABSTRACT Due to underrepresentation in genetic studies and reference panels, the promise of precision medicine for early detection, targeted treatment, and improved...
Investigating Nursing Home Emergency Preparedness for Environmental and Climatological Determinants of Resident Health
PROJECT SUMMARY The medical and functional needs of nursing home residents impose a differential risk of morbidity and mortality due to severe weather events, including hurricanes....
Transforming health at the intersection of implementation science, learning health systems, and genomics at Northwestern Medicine
Project Summary / Abstract Advances in learning health systems (LHS) and implementation science have great potential to address barriers to equitable genetic medicine. We bring tog...
Tools for comprehensive variant characterization using the pangenome
PROJECT SUMMARY / ABSTRACT This grant proposal outlines a comprehensive plan to develop novel computational methods and software tools for analyzing pangenomic data, with a focus o...
Combined Anabolic Therapy in Postmenopausal Osteoporosis
Osteoporosis affects over 20 million Americans leading to 2 million fragility fractures and 300,000 hip fractures every year. Among older adults with hip fracture, there is 5- to 8...
Simulation Analyses to Optimize Workplace Social Network Interventions for Improving Health Behaviors in Midlife
ABSTRACT Modifiable risk factors, including diet quality, have a significant impact on disability and life expectancy. Social network analyses demonstrate that social connections p...
Social Networks and Cognitive Health among Black and Latino sexual minority men in NJ
Project Summary This proposed study, aligned with RFA-AG-24-025, aims to address how interpersonal processes and social network characteristics of aging Black and Latino sexual min...