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99,167 grants found
Showing 121 – 140 of 99,167 grants
Comparison of Anti-coagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis
Symptomatic intracranial atherosclerotic stenosis (sICAS) is a common disease associated with a very high risk of stroke. Although clopidogrel + aspirin and intensive risk factor m...
Interactions of SARS-CoV-2 infection and genetic variation on the risk of cognitive decline and Alzheimer’s disease in Ancestral and Admixed Populations
The science proposed in this program takes advantage of the unique scientific opportunity created by the ongoing coronavirus pandemic, to study the interaction between a definable...
A Next Generation Data Infrastructure to Understand Disparities across the Life Course
Summary This infrastructure proposal aims to further advance capabilities in the social sciences (broadly defined) to collect data on the daily lives of U.S. families and indivi...
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies
ABSTRACT: Cognition Therapeutics, Inc. (CogRx) is developing CT1812 for neurodegenerative conditions, including Dementia with Lewy Bodies (DLB). This first-in-class small molecule...
A Next Generation Data Infrastructure to Understand Disparities across the Life Course
Summary This infrastructure proposal aims to further advance capabilities in the social sciences (broadly defined) to collect data on the daily lives of U.S. families and indivi...
Asian Cohort for Alzheimer's Disease (ACAD)
Overall Abstract Alzheimer’s disease (AD) affects 5.8 million people in the United States and is an immense burden on our economy, patients and caregivers. Genome-wide associatio...
Centrally-linked longitudinal peripheral biomarkers of AD in multi-ethnic populations
Summary Abstract (30 lines): Existing cerebrospinal fluid (CSF) and neuroimaging measures of amyloid ß, tau and neurodegeneration (A,T,N) serve as useful diagnostic biomarkers fo...
Development of a monoclonal antibody to reverse overdose from fentanyl and its analogs: from manufacturing to clinical trials
ABSTRACT. This project seeks funding to complete manufacturing and IND-supporting pharmacokinetic, efficacy, and safety/toxicology preclinical studies for a Phase I clinical trial...
Centrally-linked longitudinal peripheral biomarkers of AD in multi-ethnic populations
Summary Abstract (30 lines): Existing cerebrospinal fluid (CSF) and neuroimaging measures of amyloid ß, tau and neurodegeneration (A,T,N) serve as useful diagnostic biomarkers fo...
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)
PROJECT SUMMARY/ABSTRACT For the past 15 years, the Clinical and Translational Science Collaborative (CTSC) at Case Western Reserve University (CWRU) has linked clinical and tran...
A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies (DLB)
Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer’s disease (AD). DLB is a more rapidly progressive disease than AD, wi...
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)
PROJECT SUMMARY/ABSTRACT For the past 15 years, the Clinical and Translational Science Collaborative (CTSC) at Case Western Reserve University (CWRU) has linked clinical and tran...
Asian Cohort for Alzheimer's Disease (ACAD)
Overall Abstract Alzheimer’s disease (AD) affects 5.8 million people in the United States and is an immense burden on our economy, patients and caregivers. Genome-wide associatio...
Coordinating and Data Sharing Center - R&D of Vaccines and Antibodies for Pandemic Preparedness (ReVAMPP)
0BPROJECT SUMMARY/ABSTRACT The global pandemic caused by SARS-CoV-2 highlighted the continual threat of emerging and re-emerging pandemic-potential pathogens and the critical val...
The Development and Evaluation of Pan-Coronavirus Vaccines
Overall Summary Given the historical outbreaks of coronaviruses, coupled with the recent emergence of SARS- CoV-2 and the destabilizing consequence of COVID-19 on global health a...
CODA: COvid and Diabetes Assessment
Project Summary Several studies have found that infection with SARS-CoV-2 and COVID-19 diagnosis are associated with the development and progression of both Type 1 (T1D) and Type...
NUCATS CTSA UM1 at Northwestern University
PROJECT SUMMARY/ABSTRACT Over prior funding cycles, the Northwestern University Clinical and Translational Sciences (NUCATS) Institute has developed and delivered a robust instit...
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)
ABSTRACT The goal of this proposal is to create a resource for studying the genetic etiology of Alzheimer disease (AD) in understudied and underserved populations. Alzheimer dise...
Discovering Durable Pan-Coronavirus Immunity
OVERALL SUMMARY Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is a devastating human threat. While successful vaccine programs are underway, genetic drift and immu...
Longitudinal multicenter head-to-head harmonization of tau PET tracers
Project Summary/Abstract: The development of tau positron emission tomography (PET) tracers has yielded the opportunity to better understand the tau accumulation associated with...