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99,167 grants found
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Decreased SRD5A2 and Alternative Estrogen Signaling in Prostatic Cell Survival
PROJECT SUMMARY Benign prostatic hyperplasia (BPH) remains a significant and incurable health problem that will become more prevalent as life expectancy increases. Despite the intr...
4/5-Clinical Outcome Prediction of Psychosis from EHRs (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
2/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
The California Abundant Birth Project Evaluation: Advancing Birth Equity through Guaranteed Income for Pregnant People
Project Summary/Abstract Pregnancy is a critical period of development: stress during pregnancy can lead to adverse birth and long-term health outcomes, as well as compromise infan...
Increasing Access to Hearing Healthcare: An Assessment of Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies
Project Summary/Abstract Hearing loss is a major public health concern due to its negative association with emotional well-being, cognition, and physical ailments, such as diabetes...
Sox4 Dependent Parietal Cell Plasticity in Gastric Ulcer
PROJECT SUMMARY/ABSTRACT Gastric ulcer is increasing in the United States due to increasing use of non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection....
Chemical Approaches to Modulate PAX3-FOXO1 in Fusion-Positive Alveolar Rhabdomyosarcoma
PROJECT SUMMARY/ABSTRACT Fusion-positive alveolar rhabdomyosarcoma (FP-RMS) remains a poorly understood but highly fatal cancer of childhood. The pathognomonic fusion oncoprotein o...
Flexible bioelectronics platform converging capillary-like delivery network and sensing feedback network for improving cardiac tissue engineering
Project Summary Cardiac diseases remain the leading cause of human morbidity and mortality. Cardiac microtissues/organoids built from human induced pluripotent stem cell–derived ca...
Integrating PrEP Decision-Making into Contraceptive Counseling in Family Planning Clinics
Problem: There is high unmet need for PrEP among cis-gender women in the U.S. Even where resources are available to support PrEP, it remains inaccessible to women because too few c...
A Multi-Level Integrated Strategy to Optimize PrEP Adherence for Black MSM and Accelerate Implementation at Scale
PROJECT SUMMARY Scalable interventions that facilitate adherence to HIV PrEP are urgently needed to address the alarming HIV incidence in Black MSM. In 2020, only 26% of Black MSM...
Measuring kidney NaCl transport in vivo with genetically encoded sensors
Abstract Nephron salt reabsorption is essential to salt and water homeostasis and its dysregulation is involved in the progression of kidney and cardiovascular diseases, including...
Nephrogenesis on a chip: an simple modular platform to spatially pattern extracellular matrix, stromal cells, and soluble factors
Abstract It is well appreciated that the spatial organization of the biophysical and biochemical cues in the extracellular matrix (ECM) in concert with the stromal cell organizatio...
Adolescents' Social Media Management Strategies: Bidirectional Links to Objective Social Media Use and Mental Health Outcomes
PROJECT SUMMARY The past decade has witnessed exponential surges in social media use among U.S. adolescents. Meanwhile, as mental health problems increase for all ages, the adverse...
Novel doula intervention to leverage clinic-community connections to support perinatal intimate partner violence survivors
ABSTRACT Intimate partner violence (IPV) during the perinatal period is a pervasive and devastating public health epidemic. IPV also intersects with structural and institutional vi...
Estimating acute impacts of unconventional oil and gas development on cause-specific hospitalization via satellite-based exposure assessment
Project summary Onshore expansion of Unconventional oil and gas development (UOGD) is considered an emerging environmental health issue due to its disproportional proliferation in...
Antibodies in the neurologic effects of COVID-19
Abstract: The neurological manifestations of SARS-CoV-2 infection, known as neuroCOVID-19, have raised concerns regarding the underlying mechanisms and potential involvement of ant...
Head and neck anthropomorphic phantoms for MRI methods development at low and high fields
Project Summary/Abstract 7T MRI systems are installed worldwide more and more rapidly and are currently being evaluated in clinics for a number of conditions such as detection of s...
Optical Phantoms Mimicking Microvascular Cerebral Blood Flow (Supplement)
PROJECT SUMMARY The primary goal of this administrative supplement project is to characterize, optimize and disseminate the optical phantoms mimicking microvascular cerebral blood...
Reducing prostate cancer mortality in African American men by early disease detection using DNA fragmentation profiles and methylated DNA patterns of plasma derived cell free DNA
Project Summary/Abstract: African American (AA) individuals with prostate cancer (PCa) face significantly worse clinical outcome than their European American (EA) counterparts. The...
Remote, Young Adult Lay-Counselor Delivered Behavioral and Digital Intervention for Youth to Promote Vaping Cessation and Prevent Escalation of Tobacco Use
PROJECT SUMMARY/ABSTRACT While tobacco smoking has declined dramatically among adolescents and is now almost rare, the prevalence of electronic nicotine delivery device (ENDS, nico...